Chemical composition and great applications to the fruit of the pomegranate (Punica granatum): a review

Coronado-Reyes, Jesús Alberto; Cortés-Penagos, Carlos; González‐Hernández, Juan Carlos

doi:10.1590/fst.29420

Cited by 11 publications

(8 citation statements)

References 31 publications

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“…Pomegranate (Punica granatum) fruit is known as 'miracle fruit' because of its vast food and pharmaceutical applications. The seeds are wrapped with juicy edible pulp and are consumed as food, pressed for juice production, and used as functional foods (Coronado-Reyes et al, 2021;Hegazi et al, 2021). Pomegranate fruit, peel, seeds and juice have high medicinal applications for treating and preventing various diseases such as inflammation, diabetes, diarrhea, obesity, dysentery, dental plaque and malaria (Ismail et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of extraction process and storage time on the quality attributes of pomegranate juice of two local pomegranate varieties

Al-Kuraieef

Al-Juhani

2022

Ital. J. Food Sci.

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This study investigates the impact of two extraction processes (squeezing the whole fruit and centrifuging the seeds) of pomegranate juice and storage on sweet and sour pomegranate quality attributes. The pH, acidity, and levels of organic acids, sugars and anthocyanin differed in both varieties and changed during the storage period. Fructose and glucose were the primary sugars, and citric acid was the dominant organic acid in the juice of both cultivars. A high level of established anthocyanin content was 15.40, 18.53, 18.03, 16.92, 16,68 and 15.47 mg/L when the storage period was 0, 5, 15, 32, 48 and 72 h, respectively, in the juice of sweet fruits obtained by squeezing the whole fruit. The juice prepared from the sweet fruits by squeezing method outscored, in all sensory quality attributes, the juice prepared by centrifuging process.

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Section: Introductionmentioning

confidence: 99%

Effect of extraction process and storage time on the quality attributes of pomegranate juice of two local pomegranate varieties

Al-Kuraieef

Al-Juhani

2022

Ital. J. Food Sci.

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“…Similar results were observed by Zivkovic et al [ 49 ]; they found that pomegranate wastewater extract contains punicalin (197.13 mg/g), punicalagin (54.23 mg/g), and ellagic acid (25.42 mg/g) found to be dominant in peel extract. On the other hand, Coronado-Reyes et al [ 50 ] found that pomegranate peel is a more important source of punicalagin and ellagic acid than aryls, where the punicalagin content of the crust ranged from 114.6 to 282 mg/g dry weight. The ellagic acid content varied from 1.07 to 2.49 mg/g dry weight.…”

Section: Resultsmentioning

confidence: 99%

Pomegranate Pomace Extract with Antioxidant, Anticancer, Antimicrobial, and Antiviral Activity Enhances the Quality of Strawberry-Yogurt Smoothie

et al. 2022

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Valorizing the wastes of the food industry sector as additives in foods and beverages enhances human health and preserves the environment. In this study, pomegranate pomace (PP) was obtained from the company Schweppes and exposed to the production of polyphenols and fiber-enriched fractions, which were subsequently included in a strawberry-yogurt smoothie (SYS). The PP is rich in carbohydrates and fibers and has high water-absorption capacity (WAC) and oil-absorption capacity (OAC) values. The LC/MS phenolic profile of the PP extract indicated that punicalagin (199 g/L) was the main compound, followed by granatin B (60 g/L) and pedunculagin A (52 g/L). Because of the high phenolic content of PP extract, it (p ≤ 0.05) has high antioxidant activity with SC50 of 200 µg/mL, besides scavenging 95% of DPPH radicals compared to ascorbic acid (92%); consequently, it reduced lung cancer cell lines’ viability to 86%, and increased caspase-3 activity. Additionally, it inhibited the growth of pathogenic bacteria and fungi i.e., L. monocytogenes, P. aeruginosa, K. pneumonia, A. niger, and C. glabrata, in the 45–160 µg/mL concentration range while killing the tested isolates with 80–290 µg/mL concentrations. These isolates were selected based on the microbial count of spoiled smoothie samples and were identified at the gene level by 16S rRNA gene sequence analysis. The interaction between Spike and ACE2 was inhibited by 75.6%. The PP extract at four levels (0.4, 0.8, 1.2, and 1.4 mg/mL) was added to strawberry-yogurt smoothie formulations. During 2 months storage at 4 °C, the pH values, vitamin C, and total sugars of all SYS decreased. However, the decreases were gradually mitigated in PP-SYS because of the high phenolic content in the PP extract compared to the control. The PP-SYS3 and PP-SYS4 scored higher in flavor, color, and texture than in other samples. In contrast, acidity, fat, and total soluble solids (TSS) increased at the end of the storage period. High fat and TSS content are observed in PP-SYS because of the high fiber content in PP. The PP extract (1.2 and 1.6 mg/mL) decreases the color differences and reduces harmful microbes in PP-SYS compared to the control. Using pomegranate pomace as a source of polyphenols and fiber in functional foods enhances SYS’s physiochemical and sensory qualities.

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“…More specifically, PLE inhibits cell proliferation in the non-small cell lung carcinoma cell line and affects H1299 cell survival by arresting cell cycle progression in G2/M phase in a dose-dependent manner and inducing apoptosis ( Li et al, 2016 ). In other studies, it was shown that PLE contains abundant polyphenols, mainly gallotannins, ellagitannins, and ellagic acid ( Sreekumar et al, 2014 ; Alberto Coronado-Reyes et al, 2021 ), that was found to interfere with proliferation, cell cycle progression, and apoptosis in vitro and in vivo ( Kiraz et al, 2016 ; Tibullo et al, 2016 ; Sharifiyan et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Novel assay to measure chromosome instability identifies Punica granatum extract that elevates CIN and has a potential for tumor- suppressing therapies

Гончаров

Kovalskaia

Romanishin

et al. 2022

Front. Bioeng. Biotechnol.

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Human artificial chromosomes (HACs) have provided a useful tool to study kinetochore structure and function, gene delivery, and gene expression. The HAC propagates and segregates properly in the cells. Recently, we have developed an experimental high-throughput imaging (HTI) HAC-based assay that allows the identification of genes whose depletion leads to chromosome instability (CIN). The HAC carries a GFP transgene that facilitates quantitative measurement of CIN. The loss of HAC/GFP may be measured by flow cytometry or fluorescence scanning microscope. Therefore, CIN rate can be measured by counting the proportion of fluorescent cells. Here, the HAC/GFP-based assay has been adapted to screen anticancer compounds for possible induction or elevation of CIN. We analyzed 24 cytotoxic plant extracts. Punica granatum leaf extract (PLE) indeed sharply increases CIN rate in HT1080 fibrosarcoma cells. PLE treatment leads to cell cycle arrest, reduction of mitotic index, and the increased numbers of micronuclei (MNi) and nucleoplasmic bridges (NPBs). PLE-mediated increased CIN correlates with the induction of double-stranded breaks (DSBs). We infer that the PLE extract contains a component(s) that elevate CIN, making it a candidate for further study as a potential cancer treatment. The data also provide a proof of principle for the utility of the HAC/GFP-based system in screening for natural products and other compounds that elevate CIN in cancer cells.

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Chemical composition and great applications to the fruit of the pomegranate (Punica granatum): a review

Cited by 11 publications

References 31 publications

Effect of extraction process and storage time on the quality attributes of pomegranate juice of two local pomegranate varieties

Effect of extraction process and storage time on the quality attributes of pomegranate juice of two local pomegranate varieties

Pomegranate Pomace Extract with Antioxidant, Anticancer, Antimicrobial, and Antiviral Activity Enhances the Quality of Strawberry-Yogurt Smoothie

Novel assay to measure chromosome instability identifies Punica granatum extract that elevates CIN and has a potential for tumor- suppressing therapies

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