Antimutagenic bis (2-ethylhexyl) phthalate isolated from octopus (Paraoctopus vulgaris)

Cruz-Ramírez, Susana Gabriela; López-Saiz, Carmen María; Rosas‐Burgos, Ema Carina; Cinco-Moroyoqui, Francisco Javier; Velázquez, Carlos; Hernández, Javier; Burgos‐Hernández, Armando

doi:10.1590/fst.26119

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Aging is accompanied by a decrease in the activity of the HIF-1 pathway, which is manifested as a decrease in mitochondrial function, a reduction of the number of mitochondria, and abnormal morphology (Ong et al, 2014;Bratic & Larsson, 2013). Under aging conditions, the energy metabolism disorder regulated by the mitochondrial AMPK channel leads to a decrease in ATP synthesis's efficiency and abnormal regulation of the mitochondrial mPTP channel (Cruz-Ramírez et al, 2021;Coswosck et al, 2021;Yan et al, 2020). Therefore, this study intends to use the myocardial I/R model of aged mice to evaluate the recombinant adeno-associated virus serotype 9 mediated HIF-1α transfection into aged myocardium on mitochondrial respiratory function and enzyme activity, providing a basis for further research on the protective effect of aged ischemic myocardium.…”

Section: Introductionmentioning

confidence: 99%

Effects of HIF-1α overexpression on mitochondrial function in aged mice with myocardial ischemia-reperfusion

Zou

Long

et al. 2022

Food Sci. Technol

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To evaluate the effects of HIF-1α overexpression on mitochondrial function in aged mice with myocardial ischemia-reperfusion (I/R). Mice were divided into 1) Blank (Sham) group; 2) Ischemia-reperfusion (I/R) group; 3) I/R+2ME2 group (I/R+HIF-1α blocker 2ME2. Compared with Sham group, in I/R group and I/R+2ME2 group, HR slowed down, LVDP and +dp/dtmax decreased, LVEDP, myocardial infarction area, and ROS generation rate was significantly increased; whereas the mitochondrial respiratory function (State3, RCR) and mitochondrial respiratory enzyme activity (NADH-OX, Cytc-OX and SUC-OX) were significantly reduced. Compared with the I/R group, the respiratory function of myocardial mtochondria (State3, RCR) and respiratory enzyme activity of myocardial (NADH-OX, Cytc-OX and SUC-OX) were significantly reduced in the I/R+2ME2 group; and the levels of p-HIF-1α and p-VEGF in the I/R+2ME2 group were significantly decreased. HIF-1α pathway upregulate the respiratory enzyme activity of myocardial and respiratory function of I/R myocardial mitochondria.

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Section: Introductionmentioning

confidence: 99%

Effects of HIF-1α overexpression on mitochondrial function in aged mice with myocardial ischemia-reperfusion

Zou

Long

et al. 2022

Food Sci. Technol

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GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry

Chikowe,

Bwaila,

Ugbaja

et al. 2024

Sci Rep

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Plant extracts have been useful for oral health or dentistry. However, only a few evidence-based justifications exist. This study evaluated Multidentia crassa (Hiern) Bridson & Verdc, one of the oral health-used plants in Malawi. Gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared (FT-IR) identified the extracts’ compounds. The pharmacokinetics of the identified compounds were studied using pkCSM and SwissADME, and molecular docking studies were used to identify potential drug candidates for oral health by predicting the binding affinity of the compounds to cyclooxygenases, interleukin-1 beta receptors, odontoblast cold sensor proteins, and purinergic receptor P2X3. FT-IR analysis showed characteristic peaks of phenols, carboxylic acids, alkenes, alkyl halides, amines, esters, ethers, aromatics, and lipids. GC–MS results showed the presence of 58 bioactive phytocompounds, some of which have various pharmacological activities relevant to oral health. Molecular docking further validated stigmastan-3,5-diene’s potency for analgesic and anti-inflammatory purposes. Based on a literature review, this is the first report on the bioactive compounds of M. crassa extracts showing analgesic and anti-inflammatory effects. This study's results can lead to new herbal and conventional medicines. Therefore, we recommend in vivo and in vitro studies to elucidate the pharmacological effects of the plant extracts.

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Hepatoprotective and antioxidant effects of Octopus vulgaris extract against Depakine®-induced hepatotoxicity in adult rats

Abd El-Samd,

Soliman,

Abdel-Wahab

et al. 2024

Egyptian Pharmaceutical Journal

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Background and objective Antiepileptic drug Depakine® is often used, although it can cause birth defects in both human and animals. This study’s goal was to assess the Octopus vulgaris extract’s (OE) ability to protect against the hepatotoxicity caused by Depakine in an effort to advance its clinical application. Patients and methods Four groups of adult male Wistar rats (150–180 g b.w.) have been designed at random (10 rats each) as: 1) healthy control group; 2) healthy rats treated orally with OE (50 mg/kg/day); 3) rats administrated orally with Depakine® (500 mg/kg/day); 4) rats treated with OE in combination with Depakine. Results and conclusion After 6 weeks of treatment, the results demonstrated that OE was effective in lowering Depakine®-induced hepatotoxicity. This was shown by a significant rise in liver glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) values as well as albumin and total protein levels. Additionally, there was a considerable drop in the serum levels of tumor necrosis alpha (TNF-α), interlukin-1beta (IL-1β), interlukin-4 (IL-4), interlukin-6 (IL-6), and interlukin-10 (IL-10), which exacerbated the structural recovery of the liver’s histological image. Conclusion: OE was highly effective in reducing the oxidative stress caused by Depakine® and protecting the liver from its toxic effects. OE is a viable supplement candidate for liver protection against the negative effects of that antiepileptic medication.

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Antimutagenic bis (2-ethylhexyl) phthalate isolated from octopus (Paraoctopus vulgaris)

Cited by 3 publications

References 17 publications

Effects of HIF-1α overexpression on mitochondrial function in aged mice with myocardial ischemia-reperfusion

Effects of HIF-1α overexpression on mitochondrial function in aged mice with myocardial ischemia-reperfusion

GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry

Hepatoprotective and antioxidant effects of Octopus vulgaris extract against Depakine®-induced hepatotoxicity in adult rats

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