Study on the mechanism of houttuynin inducing apoptosis of MCF-7 cells by inhibiting PI3K/AKT signaling pathway

Liu, Qian; Liu, Guangxuan; Zhu, Ying; Chao, Yingyan

doi:10.1590/fst.18721

Cited by 2 publications

(2 citation statements)

References 12 publications

(12 reference statements)

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“…The PI3K-Akt signaling pathway is involved in a variety of life activities and is directly related to the proliferation of cancer cells (Liu et al, 2022a). Rutin is an active compound with antioxidant effects that inhibit the proliferation of cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

TAO

et al. 2022

Food Sci. Technol

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The purpose of this study was to observe its in vitro inhibitory effect on human thyroid cancer cell line SW579 through PI3K-Akt pathway. In this study, the survival of cells and the inhibitory effect of gardenia tea extract (GTE) on SW579 cancer cells were firstly observed by MTT method. Further qPCR experiments were used to observe mRNA expression in SW579 cancer cells. The active compound composition in the GTE was then also determined by HPLC. The experimental results showed that GTE had almost no effect on normal primary thyroid cells and had no toxic effect, but GTE could significantly inhibit the proliferation of SW579 cancer cells. The detection of mRNA expression in SW579 cancer cells showed that GTE could upregulate the expressions of Bax, caspase-3, caspase-8 and caspase-9 and down-regulate the expressions of Bcl-2, Bcl-xL, PI3K and Akt in SW579 cancer cells. The chemical composition test showed that GTE mainly contains three compounds, namely rutin, quercetin and phloretin. It can be seen that gardenia tea can regulate the PI3K-Akt pathway of SW579 cancer cells through the effective active substances contained in it, and exert its anti-cancer effect. It is a health-care tea with good anti-cancer effect.

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Section: Discussionmentioning

confidence: 99%

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

TAO

et al. 2022

Food Sci. Technol

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“…Eicosapentaenoic acid (EPA), a fatty acid commonly found in marine organisms, has also been reported to cause arrest in MDA-MB-231 cell line (Barascu et al, 2006). Breast cancer is one of the most diagnosed, accounting for 11.6% of combined cases and 6.6% mortality (World Health Organization, 2020), representing the second cause of woman death (Siegel et al, 2016;Liu et al, 2022). In addition, this type of cancer is characterized by its capability to The values represent mean from triplicate determinations ± standard error.…”

Section: Sub-fractionsmentioning

confidence: 99%

Lipidic compounds from the muscle of white shrimp (Litopenaeus vannamei): chemical structure and effect on the proliferation and morphology of human cancer cell lines

et al. 2022

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Cancer represents the second leading cause of death worldwide, therefore, the search for chemoprotective agents is on the rise. The muscle of white shrimp (Litopenaeus vannamei) is one of the species analyzed as it has been reported as a source of compounds with antiproliferative activity. The aim of this study was to evaluate the effect of shrimp muscle-isolated compounds on cell proliferation and morphology of human cancer cell lines. The muscle underwent a process of extraction and fractionation of compounds; their effect on cell viability assays (MTT) on lung adenocarcinoma (A549), prostate carcinoma (22 Rv-1), invasive breast adenocarcinoma (MDA MB 231), colon carcinoma (HTC 116), cervix adenocarcinoma (HeLa) and non-cancerous retinal cells (ARPE-19) was measured. Morphological changes were observed using fluorescence microscopy and chemical structure data was obtained using nuclear magnetic resonance. Fraction named C5 showed the highest antiproliferative activity on HCT-116 and MDA-MB-231, without significantly affecting the control cells. Subfractions C5-3 and C5-4 presented significant antiproliferative potential in MDA-MB-231; this cell line showed morphological changes that could be related to apoptosis, and spectroscopic analysis revealed the presence of b-carotene and eicosapentaenoic acid in C5, nevertheless, further studies are needed to determine the effect of each compound.

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Study on the mechanism of houttuynin inducing apoptosis of MCF-7 cells by inhibiting PI3K/AKT signaling pathway

Cited by 2 publications

References 12 publications

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

Lipidic compounds from the muscle of white shrimp (Litopenaeus vannamei): chemical structure and effect on the proliferation and morphology of human cancer cell lines

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