Extraction of total triterpenoids from raspberry fruit and evaluation of their effects on human hepatocellular carcinoma cells

Liu, Ying; Wu, Min; Zhi, Mingyu; Tang, Ping; Ke, Leqin

doi:10.1590/fst.16722

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…Bcl-2 family proteins are apoptosis-regulating proteins and play a key role in apoptosis (Volkmann et al, 2014). Bcl-2 and Bcl-xL are typical apoptosis inhibitors, which can prevent mitochondria from releasing cytochrome C to promote cell proliferation (Ola et al, 2011;Liu et al, 2022b). On the contrary, Bax is a typical apoptosispromoting factor, and the balance of Bax and Bcl-2 and Bcl-xL in the body is related to the success rate of cancer treatment (Czabotar et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

TAO

et al. 2022

Food Sci. Technol

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The purpose of this study was to observe its in vitro inhibitory effect on human thyroid cancer cell line SW579 through PI3K-Akt pathway. In this study, the survival of cells and the inhibitory effect of gardenia tea extract (GTE) on SW579 cancer cells were firstly observed by MTT method. Further qPCR experiments were used to observe mRNA expression in SW579 cancer cells. The active compound composition in the GTE was then also determined by HPLC. The experimental results showed that GTE had almost no effect on normal primary thyroid cells and had no toxic effect, but GTE could significantly inhibit the proliferation of SW579 cancer cells. The detection of mRNA expression in SW579 cancer cells showed that GTE could upregulate the expressions of Bax, caspase-3, caspase-8 and caspase-9 and down-regulate the expressions of Bcl-2, Bcl-xL, PI3K and Akt in SW579 cancer cells. The chemical composition test showed that GTE mainly contains three compounds, namely rutin, quercetin and phloretin. It can be seen that gardenia tea can regulate the PI3K-Akt pathway of SW579 cancer cells through the effective active substances contained in it, and exert its anti-cancer effect. It is a health-care tea with good anti-cancer effect.

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Section: Discussionmentioning

confidence: 99%

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

TAO

et al. 2022

Food Sci. Technol

View full text Add to dashboard Cite

show abstract

Extraction of total triterpenoids from raspberry fruit and evaluation of their effects on human hepatocellular carcinoma cells

Cited by 1 publication

References 26 publications

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

Effect of gardenia tea on apoptosis of human thyroid cancer cell line SW579 through PI3K-Akt pathway

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