Ameliorated effect of Lactobacillus plantarum SCS2 on the oxidative stress in HepG2 cells induced by AFB1

LONG, Lan; Meng, Xiao; Sun, Jiayi; JING, Lin; CHEN, Dayi; YU, Rong

doi:10.1590/fst.16522

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…AFB1 is a common mycotoxin produced in grain crops that exhibits a complex toxicity mechanism. Our previous study found that AFB1 induces oxidative stress by producing ROS, which leads to cell damage 13 …”

Section: Discussionmentioning

confidence: 99%

“…Our previous study found that AFB1 induces oxidative stress by producing ROS, which leads to cell damage. 13 F I G U R E 7 Knockdown of nuclear factor erythroid 2-related factor 2 (Nrf2) increased the reactive oxygen species (ROS) accumulation. The values are presented as means ± SD.…”

Section: Discussionmentioning

confidence: 99%

“…Studies conducted in vitro have shown that AFB1 exposure can cause oxidative stress in primary broiler hepatocytes and human hepatocyte HepG2 cells. [12][13][14] AFB1 alters the balance between oxidants and antioxidants in the livers of chickens, rats and mice, thereby leading to the oxidative damage of biomolecules. 15,16 Mitochondria are the main organelles for aerobic respiration in eukaryotic cells; the majority (95%) of adenosine triphosphate (ATP) that is necessary for the maintenance of various liver functions is produced by them.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress is an adverse effect of AFB1 biotransformation. Studies conducted in vitro have shown that AFB1 exposure can cause oxidative stress in primary broiler hepatocytes and human hepatocyte HepG2 cells 12–14 . AFB1 alters the balance between oxidants and antioxidants in the livers of chickens, rats and mice, thereby leading to the oxidative damage of biomolecules 15,16 …”

Section: Introductionmentioning

confidence: 99%

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Aflatoxin B1 induces ROS‐dependent mitophagy by modulating the PINK1/Parkin pathway in HepG2 cells

Wang,

Long,

Luo

et al. 2024

Basic Clin Pharma Tox

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Aflatoxin B1 (AFB1) is extremely harmful to both humans and animals. Mitophagy is a selective process of self‐elimination and has an important role in controlling mitochondrial quality. The present study aimed to investigate the effect of reactive oxygen species (ROS) accumulation on AFB1‐induced mitophagy in HepG2 cells to provide a new perspective from which to design novel therapeutic strategies to treat AFB1 poisoning. ROS release was induced in HepG2 cells with AFB1 (10 μmol/L). Cell autophagy activity, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) levels, Parkin translocation and both the transcription and expression of mitophagy‐related proteins were measured when N‐acetyl‐L‐cysteine (NAC) partially decreased the ROS level, while the knockdown of nuclear factor erythroid 2‐related factor 2 (Nrf2) resulted in a large accumulation of ROS. The results reveal that NAC pretreatment ameliorated the decline in both the MMP and the ATP levels while also activating phosphoglycerate mutase 5 (PGAM5)‐PTEN‐induced kinase 1 (PINK1)/Parkin, while the Nrf2 knockdown group exhibited the opposite trend. These results suggest that AFB1‐induced mitophagy in HepG2 cells depends on ROS, and proper ROS activates mitophagy to play a protective role.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Aflatoxin B1 induces ROS‐dependent mitophagy by modulating the PINK1/Parkin pathway in HepG2 cells

Wang,

Long,

Luo

et al. 2024

Basic Clin Pharma Tox

Self Cite

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“…Lactobacillus plantarum SCS2 obviously protected against AFB1-induced oxidative stress. Thus, L. plantarum SCS2 is a high-quality lactic acid bacterium with antioxidant function that has the potential development of probiotic products (Long et al, 2022). Saccharomyces cerevisiae species screened from industrial effluents have the potential to produce Zn-enriched single cell protein that could be considered to apply to food and feed industry (Forough et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Effects of microbial preparation on production performance and rumen microbial communities of goat

YUAN

LIANG

et al. 2023

Food Sci. Technol

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This study explored effects of microbial preparation (MIP, developed by our research team) on production performance and body health of Boer goat to reveal the function of it in goat breeding industry. Compound yeast and enzyme preparation (CYP) was used to compare the function of MIP. Healthy male Boer goats (n = 15, BW = 25.31±4.06 kg) were allocated randomly into three groups as NC (Basal diet), MI (Basal diet + MIP) and CY (Basal diet + CYP). This study lasted for 71 days including 15 days for adaptation and 56 days for growth trial. Both MIP and CYP enhanced production performance such as average daily gain of goats, MIP enhanced the level of fat synthesis such as total cholesterol level significantly on day 28. As for rumen fermentation and microbial communities of goat, MIP decreased rumen pH. PCoA analysis showed that the rumen bacterial community on day 28 was significantly separated. In conclusion, MIP increased production performance, ameliorating rumen fermentation and shifting microflora. Our findings provide the evidence for the influence of probiotics on goat production performance as well as health condition.

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A facile dual-mode SERS/fluorescence aptasensor for AFB1 detection based on gold nanoparticles and magnetic nanoparticles

Gao,

Liu,

Wei

et al. 2024

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Ameliorated effect of Lactobacillus plantarum SCS2 on the oxidative stress in HepG2 cells induced by AFB1

Cited by 4 publications

References 38 publications

Aflatoxin B1 induces ROS‐dependent mitophagy by modulating the PINK1/Parkin pathway in HepG2 cells

Aflatoxin B1 induces ROS‐dependent mitophagy by modulating the PINK1/Parkin pathway in HepG2 cells

Effects of microbial preparation on production performance and rumen microbial communities of goat

A facile dual-mode SERS/fluorescence aptasensor for AFB1 detection based on gold nanoparticles and magnetic nanoparticles

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