Possible action mechanisms of vitamin D supplementation in combating obesity and obesity-related issues of bone health: a mini review

WANG, Guiqing; Jie, Zhang; Zhang, Kailong; Zhao, Qingqing; Zhou, Fang Liz; Xu, Jie; Xue, Wenshuang; ZHANG, Chunye; Fu, Caili

doi:10.1590/fst.114621

Cited by 3 publications

(3 citation statements)

References 109 publications

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“…An efficient method for improving muscle growth and strength as well as overall physical performance in older persons is the combination of resistance training and post-exercise protein supplementation (Khor et al, 2022;Velasco et al, 2022). Vitamin D intake is critical for older adults because of its widely recognized links to bone health, muscle strength and function (Li et al, 2022;Prokopidis et al, 2022b;Wang et al, 2022). The predominant form of vitamin D found in circulation is 25-hydroxyvitamin D (25(OH)D) (Bollen et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary supplements on frailty in older persons: a meta-analysis and systematic review of randomized controlled trials

Yan

WANG³

et al. 2022

Food Sci. Technol

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Frailty is a geriatric syndrome that predicts the onset of disability, morbidity and mortality in elderly people; it is a state of pre-disability and is reversible. This review aimed to assess the impact of dietary supplementation interventions in frail older adults. A systematic search of PubMed, Web of Science, Embase, and the Cochrane Library databases was performed to collect randomized controlled trials of dietary supplements for the treatment of frailty in the elderly published before March 2022. The frailty score, muscle mass, muscle strength and physical performance of the frail elderly were extracted for analysis. Metaanalysis was performed using Review Manager Version 5.4 and Stata version 15.0. Totally, 18 studies met the inclusion criteria, with 1204 participants (603 experiment group vs. 601 control group). Compared to control group, multi-nutrient nutrition intervention can significantly improve the frailty score of the elderly (MD = -0.19, 95% CI: -0.38 to -0.01, P = 0.04, I2 = 0). Protein supplementation intervention significantly improved body weight (MD = 4.86, 95% CI: 1.21 to 8.52, P = 0.009), muscle mass [lean mass (MD = 2.73, 95% CI:1.26 to 4.20, P = 0.0003)], muscle strength (MD = 1.90, 95% CI: 0.68 to 3.12, P = 0.002), and physical performance [chair stand test (MD = -2.15, 95% CI: -3.21 to -1.10, P < 0.0001)] in frail older adults compared to control. This meta-analysis and systematic review suggests that dietary supplements interventions positively influence in older people with frailty.

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Section: Discussionmentioning

confidence: 99%

The effect of dietary supplements on frailty in older persons: a meta-analysis and systematic review of randomized controlled trials

Yan

WANG³

et al. 2022

Food Sci. Technol

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“…Then it will inhibit the secretion of various proinflammatory cytokines showing anti-inflammatory effect. During this process, calcitriol, as a hormonal form of VD, exerts its immunomodulatory properties and functions through the activation of VDR, which has a direct effect on inflammatory pathways [15]. In other experiments, active VD was used to treat and inhibit palmitate to induce macrophages to produce TNF-α and IL-6.…”

Section: Vitamin D Acts On Inflammation To Influence Obesitymentioning

confidence: 99%

Effect of vitamin D on obesity and its role in the microbiota-gut-brain axis

Jin

Yin

Zhu

2023

Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022)

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Nowadays, the prevalence of obesity is popular all over the world, and the complications causes by obesity have bought heavy burden to both society and family. More trial related to the micronutrient and new metabolism toward obesity are noticed and clinicians hope to find the most common and healthy way to help patients get out of their weight difficulties. The role of vitamin D acting in obesity is increasingly being studied. Although existing experiments have proved that obesity is related to vitamin D deficiency, there are still few studies on its specific mechanism and the influence of vitamin D on obesity through Microbiota-gut-brain. This article will summarize the known mechanisms of vitamin D on adipocytes, inflammatory reaction, and enzymatic and metabolic processes that contribute to obesity and focus on the novel mechanism of vitamin D action on obesity through the Microbiota-gut-brain axis. We set a bridge between vitamin D and Microbiota-gut-brain axis and try to explain its effect from intestinal flora, intestinal barrier and nutrient absorption and insulin and leptin central neurons factors. And we suggest patients and clinicians should pay attention to vitamin D intake in daily life or during weight loss.

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“…Obesity is one of the most prevalent chronic metabolic diseases in the world, mainly caused by an energy imbalance, resulting in abnormal or excessive accumulation of body fat (Wang et al, 2022;Yildiz et al, 2021). With the advent of fastpaced life and changes in diet, the global obesity problem is rapidly spreading among adults, adolescents, and even children.…”

Section: Introductionmentioning

confidence: 99%

Effects of functional oligosaccharide on regulating gut microbiota in obese mice: a short review

et al. 2023

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Obesity is considered a complex and multifactorial disease that is rapidly spreading around the world, and it has become a global epidemic. As an "invisible organ" carrying the "second gene" of the human body, the intestinal flora participates in the metabolism of nutrients and energy in the human body. Current research suggested that gut microbiota might play a role in the development of obesity and associated comorbidities, affecting energy intake, lipid metabolism, immune responses, and endocrine functions. Functional oligosaccharides can be utilized by intestinal microorganisms to produce short-chain fatty acids, which affect the body's energy metabolism, absorption, and intestinal permeability, thereby mediating the occurrence and development of obesity. This study took obese mice as the main object and reviewed the effect of obesity on the gut microbiota, the effect of functional oligosaccharides on gut microbiota structure, and the mechanisms of gut microbiota in improving obesity, which aimed to provide therapeutic ideas for the prevention and treatment of obesity.

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Possible action mechanisms of vitamin D supplementation in combating obesity and obesity-related issues of bone health: a mini review

Cited by 3 publications

References 109 publications

The effect of dietary supplements on frailty in older persons: a meta-analysis and systematic review of randomized controlled trials

The effect of dietary supplements on frailty in older persons: a meta-analysis and systematic review of randomized controlled trials

Effect of vitamin D on obesity and its role in the microbiota-gut-brain axis

Effects of functional oligosaccharide on regulating gut microbiota in obese mice: a short review

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