Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

Liu, Huijuan; LIU, Xiaoyi; Xie, Jianchun; CHEN, Shuai

doi:10.1590/fst.111022

Cited by 2 publications

(2 citation statements)

References 121 publications

(110 reference statements)

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“…NPs inhibit the growth of HCC by modulating intestinal barrier function. In vivo studies have shown that Ganoderma lucidum polysaccharides can stimulate immune modulation and anti-tumor effects by regulating intestinal mucosal immune function [155]. In interventions with HCC mice established by HepG2 cells, ginsenoside Rg3 inhibits the overproduction of inflammatory factors and modulates the pathway of phosphoinositide 3kinase, suppressing the growth of liver cancer cells [76,156].…”

Section: Regulates Intestinal Functionmentioning

confidence: 99%

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.

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Section: Regulates Intestinal Functionmentioning

confidence: 99%

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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“…The health-promoting effects of mushrooms, including their anticancer effects, should be associated with the polysaccharides they contain, including beta-glucans [67,68]. However, according to comparative studies by Miro ńczuk-Chodakowska et al [20], black trumpet fruiting bodies are not the richest in these substances.…”

Section: Anticancer Effectmentioning

confidence: 99%

Black Trumpet [Craterellus cornucopioides (L.) Pers.]—Bioactive Properties and Prospects for Application in Medicine and Production of Health-Promoting Food

Adamska,

Felisiak

2024

Nutrients

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Black trumpet (Craterellus cornucopioides) is a mushroom present in many countries but underestimated. The aim of this publication is to present the latest state of knowledge about the chemical composition and bioactivity of C. cornucopioides and the possibility of its application in food. According to researchers, black trumpet is very rich in nutritional compounds, including unsaturated fatty acids (mainly oleic and linoleic acids), β-glucans, minerals, and vitamins as well as polyphenols and tannins. It also contains compounds influencing the sensory properties, like free amino acids and nucleotides as well as sugars and polyols, mainly mannitol. Many of the described components show high nutritional and bioactive properties. Therefore, C. cornucopioides shows antioxidant activity and immunostimulating, anti-inflammatory, and anticancer effects as well as antibacterial, antifungal, antiviral, and antihyperglycemic effects. This makes black trumpet, also called horn of plenty, a mushroom with great potential for use both in medicine and directly in food. So far, black trumpet is not widely used in food, especially processed food. There are only a few studies on the use of dried black trumpet in sausages, but there is great potential for its use in food.

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Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

Cited by 2 publications

References 121 publications

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Black Trumpet [Craterellus cornucopioides (L.) Pers.]—Bioactive Properties and Prospects for Application in Medicine and Production of Health-Promoting Food

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