Effect of Clerodendranthus spicatus (Thunb.) C. Y. Wu on the exercise ability of D-galactose-induced oxidative aging mice

Wu, Jianzhong; CHEN, Hongjiang; Wang, Dan

doi:10.1590/fst.09822

Cited by 5 publications

(4 citation statements)

References 44 publications

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“…These changes result in cellular dysfunction, in turn affecting the metabolism and accelerating the aging process ( Qian et al, 2018 ). As people age, the conduction velocity of their motor and sensory nerves gradually decreases, and this decline in the function of the nervous system causes the weakening of motor ability, which is accompanied by the frequent occurrence of fatigue ( Wu et al, 2022 ). Exercise can help clear free radicals and thereby allow normal cells to maintain the integrity of mitochondrial structure and function; simultaneously, being in good physical condition can facilitate the body to maintain exercise capacity ( Vargas-Mendoza et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

et al. 2022

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ObjectivesAging is a process that involves comprehensive physiological changes throughout the body, and improvements in the exercise capacity of individuals may delay aging and relieve fatigue. Probiotics are subject to ongoing research to investigate their antioxidant properties. The purpose of this study was to investigate the effect of the probiotic Lactobacillus plantarum KSFY01 (L. plantarum KSFY01) on exercise tolerance in mice induced into a state of accelerated physiological aging by oxidative stress.MethodsA mouse model of accelerated aging was established using D-galactose to induce oxidative stress. The bacteria L. plantarum KSFY01 was isolated from fermented yak yogurt. The effect of L. plantarum KSFY01 on the improvement of exercise capacity in aging-accelerated mice was evaluated by measuring their running time until exhaustion, histopathological sections, related biochemical indicators, and underlying gene expression.ResultsThe oral administration of L. plantarum KSFY01 prolonged the running time of mice and reduced their creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferasem (AST) levels. From this study, we observed that L. plantarum KSFY01 significantly improved the exercise capacity of mice and alleviated liver damage. Treatment with L. plantarum KSFY01 reduced the blood urea nitrogen (BUN), lactic acid (LD) accumulation, and lactate dehydrogenase (LDH) elevations produced by the accelerated aging state, and also reversed the changes in muscle glycogen (MG). Overall, L. plantarum KSFY01 could effectively improve metabolite accumulation, thereby relieving fatigue in exercised mice. The results of the antioxidant indices in vivo showed that L. plantarum KSFY01 intervention increased the activity of antioxidant enzymes, decreased the level of malondialdehyde (MDA), and restored the balance between the oxidative and antioxidant systems in fatigued mice. By investigating the underlying molecular mechanism, our results showed that L. plantarum KSFY01 intervention significantly reversed the decline in the expression levels of nuclear factor-erythroid 2 related factor 2 (Nrf2) signaling pathway-related factors and improved the body’s antioxidant capacity. We determined that the underlying molecular mechanism responsible for the antioxidant effect of L. plantarum KSFY01 mainly involves the activation of the Nrf2 pathway. The effect of L. plantarum KSFY01 was dose-dependent, and the expression level of Nrf2 increased with increasing dosage of the probiotic.ConclusionThis study demonstrated that the probiotic L. plantarum KSFY01 exerts antioxidant effects and improved the athletic ability of mice. These findings are of significance to the development and utilization of probiotic resources.

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Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

et al. 2022

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“…The mice all displayed high-frequency shortness of breath because they were unable to keep up with the treadmill's set pace and their rear limbs were pulled by the belt for more than 30 s (YH-CS, Wuhan Yihong Technology Co., Ltd, Wuhan, Hubei, China). There was no obvious response after physical stimulation (Wu et al, 2022). The time at this time was recorded.…”

Section: Running Exhaustion Test In Micementioning

confidence: 99%

The recovery effect of Feixingcao tea (Teucrium viscidum Bl.) on inhibiting the decreased exercise ability caused by chronic alcoholic liver injury

WANG¹

2022

Food Sci. Technol

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“…[ 17 ] It has been reported that monosaccharide composition affects the antioxidant activity of Polygonatum polysaccharide. [ 19 ] Su and Li [ 20 ] reported that Auricularia polysaccharides from different species showed different antioxidant capacities. The total antioxidant capacity was significantly negatively correlated with fucose and galactose, indicating that fucose and galactose jointly determine total antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Structure characterization and bioactivity of neutral polysaccharides from different sources of Polygonatum Mill

Wang

Jiang

Jin³

et al. 2022

Biopolymers

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Polygonati rhizoma (PR), a traditional medical and edible product, is rich in polysaccharides and exhibits physiological activity, including antioxidant, hypoglycemic and hypolipidemic properties. Neutral polysaccharides have been reported to be one of the main active ingredients of Polygonatum, with many of these fractions being responsible for the biological activity. This behavior was shown to be closely connected to the chemical structure, monosaccharide composition, and glycosidic bond type. There are few reports on the chemical constituents of the neutral polysaccharides from different sources of PR. In this study, neutral polysaccharides of PR from four different regions of China (Chun'an (Zhejiang), Xixia (Henan), Danfeng (Shanxi), and Pan'an (Zhejiang)), named CAZJ, XXHN, DFSX, and PAZJ, respectively, were isolated by anion‐exchange and gel‐permeation chromatography. Structures of the four polysaccharides were investigated. The results showed that all of them were mainly glucose and mannose, while the monosaccharide composition and content of polysaccharides from different sources varied. The molecular weights of CAZJ, XXHN, DFSX, and PAZJ were 14.119, 22.352, 18.127, and 15.699 kDa, respectively. Infrared spectra illustrated the existence of α‐glycosidic bond and β‐glycosidic bond in the polysaccharides. CAZJ, XXHN, and DFSX possessed a pyranose ring structure, whereas PAZJ had a furanose ring structure. Congo red test indicated that XXHN, DFSX, and PAZJ had a triple‐helix structure. X‐ray diffraction showed that the polysaccharides consisted of crystalline and amorphous regions. All four polysaccharides exhibited different degrees of antioxidant and hypoglycemic activities with a dose‐dependent manner in the 1.0–10.0 mg/mL concentration range. Correlation analysis revealed that the bioactivities of polysaccharides was significantly related to monosaccharide composition, uronic acid, and protein content. The results suggested that neutral polysaccharides could be used as potential natural antioxidants and hypoglycemic agents for functional and nutraceutical applications.

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Effect of Clerodendranthus spicatus (Thunb.) C. Y. Wu on the exercise ability of D-galactose-induced oxidative aging mice

Cited by 5 publications

References 44 publications

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

Effect of Lactobacillus plantarum KSFY01 on the exercise capacity of D-galactose-induced oxidative stress-aged mice

The recovery effect of Feixingcao tea (Teucrium viscidum Bl.) on inhibiting the decreased exercise ability caused by chronic alcoholic liver injury

Structure characterization and bioactivity of neutral polysaccharides from different sources of Polygonatum Mill

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