Effect of pumpkin seed oil on cholesterol fractions and systolic/diastolic blood pressure

Abstract

Pumpkin seed oil (PSO) is high in unsaturated fatty acids and plant sterols, which have numerous cardiovascular benefits. The study explores the hypothesis by investigating effects of consumption of 1000 mg of PSO on total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), systolic (SBP) and diastolic (DBP) blood pressure ((BP). PSO has high oxidative stability and contains favorable essential fatty acids profile along with sterols and tocopherols. One hundred and twenty-seven participants 39 to 63 years old, with varying degree of one or multiple medical conditions including dyslipidemia, hypertension, diabetes and obesity were randomly selected and assigned among case and control groups. Both groups were biochemically, anthropometrically and clinically assessed pre and post intervention. Group 1 (cases) (n=63) was administered 1000 mg of PSO along with recommendations for healthy diet and lifestyle whereas Group 2 (controls) (n=64), was only provided with dietary and lifestyle changes. Analysis of cases baseline and endpoint data revealed advantageous effect of intervention. Cases data showed a significant reduction in endpoint LDL and DBP values along with a likewise significant increase in HDL cholesterol. Experiment results revealed PSO possessed hypolipidemic and anti-hypertensive activity as it lowered DBP and LDL and increased HDL levels.

The potential of pumpkin seed oil as a functional food—A comprehensive review of chemical composition, health benefits, and safety

“…In a clinical trial involving 127 participants (39 to 63 years old) who had varying degrees of one or more diseases such as dyslipidemia, diabetes, obesity, and hypertension, Majid et al. (2020) examined the effects of consuming 1000 mg of PSO daily on total cholesterol, high‐density and low‐density lipoproteins, and systolic and diastolic blood pressure. Participants consuming PSO showed a significant decrease in endpoint values for low‐density lipoproteins and diastolic blood pressure, as well as an equally significant increase in cholesterol from high‐density lipoproteins, compared to the control group.…”

Evaluation of Total Antioxidant and Oxidant Status, Oxidative Stress Index and DPPH Free Radical Scavenging Activities of Pumpkin (Cucurbita maxima) Seeds Ethanolic Extracts

“…Oils extracted from raw pumpkin seeds due to its antioxidant potential, significantly reduced serum triglycerides, total cholesterols, LDL cholesterols, uric acid, creatinine, serum transaminases and urea in experimental animals, whereas serum HDL cholesterols were significantly increased, which was a clear indication of health promoting potential of pumpkin seeds (Nameni et al, 2021). Investigations made by Majid et al (2020) on humans by application of pumpkin seed oil, in controlled lifestyle, showed a significant reduction in endpoint LDL, significant increase in HDL cholesterol. Experiment results revealed pumpkin seed oil have potential of hypolipidemic and anti-hypertensive activity as it lowered LDL and increased HDL levels.…”

Effects of Foxc1 and Oct4 genes regulating BMSCs transplantation on cardiomyocyte apoptosis after acute myocardial infarction in rats

“…), or to culture BMSCs with myocardial cells, it can promote the differentiation of BMSCs into cardiomyocytes, and the electromechanical coupling of the two is well fused (Eldin et al, 2019;Lu et al, 2019). The number of BMSCs is not large, and it decreases with age (Majid et al, 2020;Sultan et al, 2021;Vidal et al, 2020). Therefore, we can expand in vitro to obtain more cells for research and treatment.…”