Nigella sativa ameliorates oxidative stress induced adverse effects in rodent modeling studies: Indices of serum chemistry and hematology

Abstract

In this era, various traditional medicinal herbs were researched for their toxicological and safety aspects. The present study focused on using Nigella sativa fixed (NSFO) and essential oil (NSEO) to mitigate the adverse consequences of oxidative stress. For the purpose, oxidative stress was induced in Sprague Dawley rats using potassium bromate injection. The effect of NSFO and NSEO on indices of serum chemistry and hematology were studied. The results indicated that potassium bromate imparted drastic changes in serum chemistry and hematology e.g. it increased the blood cholesterol and blood glucose along with decreasing the insulin secretion. Oxidative stress also influenced the hematological attributes negatively but experimental diets were slightly successful in normalizing the values. The experimental diets especially essential oil that contains significant quantities of thymoquinone modulated the adverse consequences of oxidative stress with special reference to hematology and serological attributes. In the nutshell, NSFO and NSEO hold potential to mitigate the oxidative stress, and improved various serological and hematological attributes.

Effects of Foxc1 and Oct4 genes regulating BMSCs transplantation on cardiomyocyte apoptosis after acute myocardial infarction in rats

“…), or to culture BMSCs with myocardial cells, it can promote the differentiation of BMSCs into cardiomyocytes, and the electromechanical coupling of the two is well fused (Eldin et al, 2019;Lu et al, 2019). The number of BMSCs is not large, and it decreases with age (Majid et al, 2020;Sultan et al, 2021;Vidal et al, 2020). Therefore, we can expand in vitro to obtain more cells for research and treatment.…”

Effect of formononetin from Trifolium pratense L. on oxidative stress, energy metabolism and inflammatory response after cerebral ischemia-reperfusion injury in mice

“…Formononetin can prevent the myocardial from ischemia-reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway (Wang et al, 2020). It is found that many plants or their extracts have the antioxidant, anti-inflammatory and other activities (Costa et al, 2020;Hu et al, 2021;Sultan et al, 2021). This study was to investigate the effect of formononetin from Trifolium pratense L. on oxidative stress, energy metabolism and inflammatory response after CIRI in mice.…”