Function and mechanism of the human SOD2 gene in mice cerebral ischemia/ reperfusion injury
Xitong Yang,
Guangming Wang
Abstract:Purpose:
To investigate the neuroprotective effects of the SOD2 gene in cerebral ischemia reperfusion injury function and the underlying mechanisms in a mice model of middle cerebral artery ischemia reperfusion.
Methods:
SOD2 transgenic mice were engineered using transcription activator-like effector nucleases, and the genotype was identified using PCR after every three generations. Transgenic and C57BL/6J wild type mice were simultaneously subjected to the middle cereb… Show more
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