Anatomical description of the extratemporal facial nerve under high-definition system: a microsurgical study in rats

Pinto, Marcela Maria Rabelo; Santos, Deivid Ramos dos; Bentes, Lívia Guerreiro de Barros; Lemos, Rafael Silva; Almeida, Nyara Rodrigues Conde de; Fernandes, Manuela Rodrigues Neiva; Braga, Joyce Pantoja; Somensi, Danusa Neves; Barros, Rui Sergio Monteiro de

doi:10.1590/acb370803

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Although BBFN is important for innervating rat vibrissae, it is not the only one that performs this function; therefore, the paralysis is not complete with its disruption [ 68 , 69 ]. However, BBFN denervation causes a significant functional loss, as observed in our results.…”

Section: Discussionmentioning

confidence: 99%

Delayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration

Bueno,

Buchaim,

Barraviera

et al. 2024

J. Venom. Anim. Toxins incl. Trop. Dis

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Background: In this experimental protocol, we evaluated the immediate and delayed repair of the buccal branch of the facial nerve (BBFN) with heterologous fibrin biopolymer (HFB) as a coaptation medium and the use of photobiomodulation (PBM), performing functional and histomorphometric analysis of the BBFN and perioral muscles. Methods: Twenty-eight rats were divided into eight groups using the BBFN bilaterally (the left nerve was used for PBM), namely: G1 - control group, right BBFN (without injury); G2 - control group, left BBFN (without injury + PBM); G3 - Denervated right BBFN (neurotmesis); G4 - Denervated left BBFN (neurotmesis + PBM); G5 - Immediate repair of right BBFN (neurotmesis + HFB); G6 - Immediate repair of left BBFN (neurotmesis + HFB + PBM); G7 - Delayed repair of right BBFN (neurotmesis + HFB); G8 - Delayed repair of left BBFN (neurotmesis + HFB + PBM). Delayed repair occurred after two weeks of denervation. All animals were sacrificed after six weeks postoperatively. Results: In the parameters of the BBFN, we observed inferior results in the groups with delayed repair, in relation to the groups with immediate repair, with a significant difference ( p < 0.05) in the diameter of the nerve fiber, the axon, and the thickness of the myelin sheath of the group with immediate repair with PBM compared to the other experimental groups. In measuring the muscle fiber area, groups G7 (826.4 ± 69.90) and G8 (836.7 ± 96.44) were similar to G5 (882.8 ± 70.51). In the functional analysis, the G7 (4.10 ± 0.07) and G8 (4.12 ± 0.08) groups presented normal parameters. Conclusion: We demonstrated that delayed repair of BBFN is possible with HFB, but with worse results compared to immediate repair, and that PBM has a positive influence on nerve regeneration results in immediate repair.

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Section: Discussionmentioning

confidence: 99%

Delayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration

Bueno,

Buchaim,

Barraviera

et al. 2024

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Therefore, regarding the functional analysis, BBFN is not the only one that provides motor innervation to rat vibrissae. When we only denervate this branch, we should not expect complete functional loss and total paralysis [ 69 , 70 ]. In the denervated group (DGn and DGl) there was loss of movement after 6 weeks, without total paralysis, probably due to having received innervation from another terminal branch of the facial nerve, such as the zygomatic.…”

Section: Discussionmentioning

confidence: 99%

Morphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation

et al. 2023

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Peripheral nerve injuries impair the patient’s functional capacity, including those occurring in the facial nerve, which require effective medical treatment. Thus, we investigated the use of heterologous fibrin biopolymer (HFB) in the repair of the buccal branch of the facial nerve (BBFN) associated with photobiomodulation (PBM), using a low-level laser (LLLT), analyzing the effects on axons, muscles facials, and functional recovery. This experimental study used twenty-one rats randomly divided into three groups of seven animals, using the BBFN bilaterally (the left nerve was used for LLLT): Control group—normal and laser (CGn and CGl); Denervated group—normal and laser (DGn and DGl); Experimental Repair Group—normal and laser (ERGn and ERGl). The photobiomodulation protocol began in the immediate postoperative period and continued for 5 weeks with a weekly application. After 6 weeks of the experiment, the BBFN and the perioral muscles were collected. A significant difference (p < 0.05) was observed in nerve fiber diameter (7.10 ± 0.25 µm and 8.00 ± 0.36 µm, respectively) and axon diameter (3.31 ± 0.19 µm and 4.07 ± 0.27 µm, respectively) between ERGn and ERGl. In the area of muscle fibers, ERGl was similar to GC. In the functional analysis, the ERGn and the ERGI (4.38 ± 0.10) and the ERGI (4.56 ± 0.11) showed parameters of normality. We show that HFB and PBM had positive effects on the morphological and functional stimulation of the buccal branch of the facial nerve, being an alternative and favorable for the regeneration of severe injuries.

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Anatomical description of the extratemporal facial nerve under high-definition system: a microsurgical study in rats

Cited by 2 publications

References 28 publications

Delayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration

Delayed repair of the facial nerve and its negative impacts on nerve and muscle regeneration

Morphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation

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