Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives

Pasmatzi, Efstathia; Papadionysiou, Christina; Monastirli, Alexandra; Badavanis, George; Tsambaos, D.

doi:10.1590/abd1806-4841.20198426

Cited by 11 publications

(13 citation statements)

References 65 publications

(84 reference statements)

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“…Table (3) shows the relationship in current research between galectin-3 and other parameters. It noticed an important positive association between galectin-3 and ACR, and glucose in all patients.…”

Section: Correlation Of Serum Galectin-3 With Other Parameter In Researchmentioning

confidence: 99%

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Association of Serum Galectin-3 Level with Albuminuria and Renal Function in Type 2 Diabetic Iraqi Patients

Najlaa abed jassim,

Sanad Baqir Mahammad,

Tawfeeq F.R. AL-Auqbi

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Galectin-3 is a category of β-galactoside binding Lectin. It has been involved in renal inflammation and fibrosis. We examined the relationship between galectin-3 level and nephropathy in T2DM patients with or without microalbuminuria in comparison healthy controls.Methods: Ninety T2DM patients they were graded as (3 groups) depending on (ACR) albumin to creatinine value: normalbuminuria (ACR < 30 mg / g), micro albuminuria (ACR 30-300 mg / g); and macroalbuminuria (ACR > 300 mg / g). In addition, 30 healthy control subject. The serum galectin-3 was determined by an enzyme-linked immune sorbent assay (ELISA) for 90 T2DM patients and 30 healthy subjects. And also biochemical parameters measured included FBG, HbA1c, urea, creatinine, and uric acid.Result: Serum galectin-3 was significantly raised in T2DM patients with macroalbuminuria in comparing to healthy group and also to other patients groups (p<0.001). Galectin-3 level was positively related with each of ACR, FBS, HbA1c, urea, creatinine. whilst, eGFR was negatively correlated with galectin-3 Conclusion: Galectin-3 level is essentially higher with T2DM at all stages of DN, particularly in macroalbuminuria patients.

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Section: Correlation Of Serum Galectin-3 With Other Parameter In Researchmentioning

confidence: 99%

“…It is expressed mainly in macrophage, endothelial and also epithelial cells. It has a regulator effect in the cell processes and the pathogenetic mechanism of various disorganizations [3] . During the discovery of galectin-3, it has been recognized in the intracellular and extracellular space.…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Galectin-3 Level with Albuminuria and Renal Function in Type 2 Diabetic Iraqi Patients

Najlaa abed jassim,

Sanad Baqir Mahammad,

Tawfeeq F.R. AL-Auqbi

2021

Indian Journal of Forensic Medicine & Toxicology

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“…At least 15 galectins have been described in mammalians so far and they have been divided into three groups based on their CRD number, structure, and properties [ 11 , 13 , 14 , 15 ]. Galectins, by binding saccharides in glycoconjugates on the cell surface, exert multimodal biological roles, not yet fully known, in the regulation of cell–cell and cell–matrix interactions, immunity, expression of certain genes, regeneration, apoptosis, and cancer progression [ 11 , 12 , 14 , 16 , 17 ]. It is noteworthy that the molecules can act opposite, depending on various conditions, serving as positive or negative modulators of the same processes [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data

Baran

Kiluk

Nowowiejska

et al. 2022

Biology

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Galectin-3 (gal-3) is a multifunctional regulator of various biological processes and diseases, which are common comorbidities in psoriasis. Data regarding potential diagnostic role of gal-3 in psoriasis are insufficient. Serum gal-3 levels were evaluated before and after twelve weeks of treatment with acitretin or methotrexate in 31 patients with plaque-type psoriasis and compared to 11 healthy control group. The mean serum galectin-3 level in patients with psoriasis was significantly higher compared to the control group (p < 0.01). In patients with obesity and long-lasting psoriasis (>20 years) positive relations of gal-3 and PASI were noted. In psoriatics with low gal-3 levels, positive correlations between the gal-3 and BMI, glucose level, and with the latter in short-lasting psoriasis (<20 years) were noted. In the long history of psoriasis, gal-3 was negatively correlated with lipids levels. The Gal-3 level might be a multifaceted modulator of the course of psoriasis and predictive factor of cardiometabolic comorbidities’ development, especially in patients with a long history of the disease or obesity. Patients with low serum gal-3 and short history of psoriasis are presumably at greater risk of diabetes. In patients with long-lasting psoriasis and concomitant obesity, gal-3 may exert a protective role against dyslipidemia or perhaps further CMD development.

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“…Most galectins share a unique structural unit termed the carbohydrate-recognition domain (CRD), which is made up of about 130 amino acids. Some galectins, however, possess two homologous CRDs in a single polypeptide chain separated by a linker of up to 70 amino acids (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

In contrast to melanocytes, keratinocytes of normal human adult interfollicular epidermis do not express galectin-1

Pasmatzi

Papadionysiou

Badavanis

et al. 2020

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Galectins constitute a phylogenetically conserved family of proteins that specifically bind to glycoconjugates bearing β-galactoside residues. Although galectin-1 (Gal 1), the first identified member of the galectin family, is involved in highly important biological processes at the molecular and cellular level in human skin, its expression in keratinocytes of normal human adult interfollicular epidermis (NHAIE) remains in dispute, whereas that in epidermal melanocytes has drawn very little attention so far. This prompted us to investigate the expression of Gal 1 in the keratinocytes and melanocytes of NHAIE. Methods: Biopsy specimens obtained from the buttock skin of 23 healthy adult volunteers of both sexes were processed for single and double immunohistochemical staining using antibodies against Gal 1 and Melan-A. Results: In contrast to epidermal melanocytes, which revealed a distinct Gal 1 immunoreactivity, keratinocytes of NHAIE were completely devoid of any expression of this galectin. Conclusions: This article simultaneously assesses Gal 1 immunoreactivity of keratinocytes and melanocytes in NHAIE for the first time. Our findings may contribute to a better understanding of alterations in Gal 1 expression in various benign and malignant cutaneous disorders and may be of importance for the future design of targeted therapies.

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Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives

Cited by 11 publications

References 65 publications

Association of Serum Galectin-3 Level with Albuminuria and Renal Function in Type 2 Diabetic Iraqi Patients

Association of Serum Galectin-3 Level with Albuminuria and Renal Function in Type 2 Diabetic Iraqi Patients

Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data

In contrast to melanocytes, keratinocytes of normal human adult interfollicular epidermis do not express galectin-1

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