2019
DOI: 10.1590/abd1806-4841.20198109
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Incapacitating solar urticaria: successful treatment with omalizumab

Abstract: Solar urticaria is a rare form of physical urticaria mediated by immunoglobulin E. The lesions appear immediately after the sun exposure, interfering with the patient's normal daily life. Omalizumab, a monoclonal anti-IgE antibody, has been recently approved for the treatment of chronic spontaneous urticaria, and the latest reports support its role also in the treatment of solar urticaria. Hereby, we report a case of solar urticaria refractory to conventional treatment strategies, with an excellent response to… Show more

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Cited by 4 publications
(3 citation statements)
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“…Solar urticaria/solar angioedema is induced by UVB/UVA/VL; the use of tinted sunscreens is required for those with VL as the action spectrum 61 . Other treatments include antihistamines, UVA/UVA1 rush hardening, cyclosporine and omalizumab 62‐64 …”
Section: Photodermatosesmentioning
confidence: 99%
See 1 more Smart Citation
“…Solar urticaria/solar angioedema is induced by UVB/UVA/VL; the use of tinted sunscreens is required for those with VL as the action spectrum 61 . Other treatments include antihistamines, UVA/UVA1 rush hardening, cyclosporine and omalizumab 62‐64 …”
Section: Photodermatosesmentioning
confidence: 99%
“…61 Other treatments include antihistamines, UVA/UVA1 rush hardening, cyclosporine and omalizumab. [62][63][64] Drug-induced phototoxicity and photoallergy Drug-induced phototoxicity from the interaction of topical or systemic agents with UVA 65 manifests as an exaggerated sunburn reaction with rapid onset. This is not to be mistaken with photoallergy, which generally has delayed onset at 24-48 h after sun exposure, and requires only a minimal concentration of the photoallergen to induce the lesions in photosensitized individuals.…”
Section: Solar Urticariamentioning
confidence: 99%
“…It typically presents with short-lasting, pruritic, erythematous patches and wheals that form approximately five to ten minutes after exposure to sunlight. Solar urticaria can also be associated with systemic manifestations, such as dizziness, headaches, nausea, syncope, wheezing, and rarely anaphylactic shock [1][2][3]10].…”
Section: Discussionmentioning
confidence: 99%