Pigmented lesions are a frequent challenge for dermatologists, due the difficulty of differential diagnosis between common entities in clinical practice, such as seborrhoeic keratosis, basal cell carcinoma, melanocytic lesions and adnexal tumours. A thorough history and physical examination, always accompanied by dermoscopy, are essential.We report here 2 cases of middle-aged patients, who were otherwise healthy, with solitary acquired pigmented lesions, who were referred to our dermatology department in order to rule out malignant melanoma. Case 1. A 55-year-old man presented with an excrescent, dark-brown lesion, 13 mm in diameter located on his right shoulder. Dermoscopy revealed irregular polymorphous vascularity, blue-grey ovoid nests, and keratinization. The patient reported that the lesion had grown in the last years. The lesion was excised and sent to the pathology department (Fig. 1). Case 2. A 65-year-old woman with a firm, slow-growing, black nodule, 15 mm largest diameter, located on the inner side of her left thigh was referred to our unit. Dermoscopy revealed blue-grey pigmentation, globule-like structures, comedo-like structures, irregular vascularity and keratinization. The lesion was removed and sent for histology (Fig. 2).