Generalized linear porokeratosis

Escanilla-Figueroa, Claudio; Jimeno-Ortega, Isabel; Fuenzalida-Wong, Héctor; Chávez-Rojas, Francisco

doi:10.1590/abd1806-4841.20187798

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…The lesions are usually unilateral, yet bilateral or generalised LPs have also been also reported [52,114,377,[381][382][383]. The plaques are anhidrotic and alopecic [384] and rarely may start as erosions [376]. A case with a giant cornoid lamella has also been reported [385].…”

Section: Linear Porokeratosis (Lp) 61 Clinical Presentationmentioning

confidence: 99%

“…There are two reports on phalangeal nail and bone abnormalities [387,391] and pseudoainhum [392] associated with LP. This subtype is regarded to be a form of post-zygotic cutaneous mosaicism and should be differentiated at the clinical level from other Blaschko-linear papulokeratotic dermatoses, both congenital and acquired, including inflammatory linear verrucous epidermal nevus (ILVEN), porokeratotic eccrine ostial and dermal duct nevus (PEODDN), lichen striatus, linear lichen planus, linear Darier's disease, linear psoriasis, linear incontinentia pigmenti, elastosis perforans serpiginosa, ichthyosis linearis circumflexa and linearly arranged viral warts [377,378,384,393]. Liver disease [394] and Bardet-Biedl syndrome [395] were suggested to be linked to LP.…”

Section: Genetics and Epigeneticsmentioning

confidence: 99%

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Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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Section: Linear Porokeratosis (Lp) 61 Clinical Presentationmentioning

confidence: 99%

Section: Genetics and Epigeneticsmentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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“…Protein p53 expression has been considered as a possible marker of malignant degeneration in patients with porokeratosis. 3 Malignant transformation of porokeratosis is uncommon. A Singapore study by Tan et al found that 3.2% of patients with porokeratosis subsequently developed Bowen's disease and squamous cell carcinoma over various sites of porokeratosis.…”

Section: What Is the Diagnosis?mentioning

confidence: 99%

A 69-year-old woman with a linear rash

Tay

2021

Ann Acad Med Singap

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A 69-year-old woman with a linear rash IMAGES IN MEDICINEA 69-year-old Chinese woman presented with pruritic lesions in the form of linear keratotic papules on the left inframammary region for the past 2 years. On examination, there were multiple oval to round, brown, firm, keratotic papules with distinct scaly edges separated from the surrounding healthy skin (Fig. 1). She was treated with mometasone furoate ointment every morning and topical calcipotriol ointment every night for about 7 months with mild improvement.

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“…Linear porokeratosis is a skin condition in which abnormal keratinized cutaneous lesions are arranged in a linear formation, usually following dermatomes or Blaschko lines. Clinically, these lesions appear as red patches or plaques and are typically unilateral in nature [1]. Histologically, porokeratoses are characterized by the cornoid lamellae, which present as vertical columns of parakeratosis and dyskeratotic cells found in the granular layer of the epidermis [2].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Linear Porokeratosis Treated With Topical Cholesterol 2%/Lovastatin 2%

Diep¹,

Janitz²,

Kannan³

et al. 2022

Cureus

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Linear porokeratosis is a cutaneous disorder that typically presents in a unilateral linear formation. While the exact cause of linear porokeratosis is unknown, it is thought to be a downstream effect of disrupted cholesterol synthesis and mevalonate accumulation.Our patient is a 61-year-old male with an unusual case presentation of bilateral linear porokeratosis. He had failed numerous standard therapies. Pathologic examination of a skin biopsy was consistent with bilateral linear porokeratosis. Through a PubMed search, there have been limited reported cases of unilateral linear porokeratosis, but there have not been any reported cases of bilateral linear porokeratosis.There are currently limited therapies with satisfactory outcomes for variants of porokeratosis. While there are some studies on the topical application of cholesterol/lovastatin, limited studies have been performed on the linear form. Our study evaluates the efficacy of compounded topical cholesterol 2%/lovastatin 2% ointment on bilateral linear porokeratosis. The patient demonstrated a significant reduction of porokeratotic lesions on the treated arm compared to the untreated arm. Cholesterol/lovastatin is alternative therapy that can be considered in the treatment of linear porokeratosis and other porokeratosis variants.

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Generalized linear porokeratosis

Cited by 4 publications

References 2 publications

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

A 69-year-old woman with a linear rash

Bilateral Linear Porokeratosis Treated With Topical Cholesterol 2%/Lovastatin 2%

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