Chromoblastomycosis due to Cladosporium langeronii. Molecular diagnosis of an agent previously diagnosed as Fonsecaea pedrosoi

Torres-Guerrero, Edoardo; Castro, Rigoberto Hernández

doi:10.1590/abd1806-4841.20187644

Cited by 4 publications

(4 citation statements)

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“…A case of chromomycosis due to Cladosporium halotolerans: Successful identification of previously unreported pathogen with a molecular approach Dear Editor, Chromomycosis is a chronic subcutaneous fungal infection mostly caused by Fonsecaea, Phialophora, and Cladophialophora. 1,2 Here, we report a case of chromomycosis caused by Cladosporium halotolerans. To the best of our knowledge, this is a previously unreported case of chromomycosis due to this pathogen.…”

Section: E T T E R T O T H E E D I T O Rmentioning

confidence: 95%

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A case of chromomycosis due to Cladosporium halotolerans: Successful identification of previously unreported pathogen with a molecular approach

Iwasaki,

Shimoda‐Komatsu,

Ida

et al. 2024

The Journal of Dermatology

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Section: E T T E R T O T H E E D I T O Rmentioning

confidence: 95%

“…Tatsuro Iwasaki 1,2 Yurie Shimoda-Komatsu 1 Yoko Ida 3 Hiroaki Shimoyamada 4 Tomoo Fukuda 1,5 Manabu Ohyama…”

Section: Co N Fli C T O F I Nter E S T S Tatem Entmentioning

confidence: 99%

A case of chromomycosis due to Cladosporium halotolerans: Successful identification of previously unreported pathogen with a molecular approach

Iwasaki,

Shimoda‐Komatsu,

Ida

et al. 2024

The Journal of Dermatology

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“…In addition to the Herpotrichiellaceaea family, another important family is Cladosporiaceae, and the most important species associated with CBM in animals and humans [86] are C. cladosporioides [72], C. herbarum [25], C. langeronii [26], and C. sphaerospermum [27]. In culture, colonies of this genus assume a grayish-greenish color [87], and conidia appear as branched chains and are adapted to spread over long distances [88].…”

Section: Diversity Of Etiologic Agents Of Cbmmentioning

confidence: 99%

Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis

Passero

Cavallone

Belda

2021

Journal of Immunology Research

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Chromoblastomycosis (CBM) is a neglected human disease, caused by different species of pigmented dematiaceous fungi that cause subcutaneous infections. This disease has been considered an occupational disease, occurring among people working in the field of agriculture, particularly in low-income countries. In 1914, the first case of CBM was described in Brazil, and although efforts have been made, few scientific and technological advances have been made in this area. In the field of fungi and host cell relationship, a very reduced number of antigens were characterized, but available data suggest that ectoantigens bind to the cell membrane of host cells and modulate the phagocytic, immunological, and microbicidal responses of immune cells. Furthermore, antigens cleave extracellular proteins in tissues, allowing fungi to spread. On the contrary, if phagocytic cells are able to present antigens in MHC molecules to T lymphocytes in the presence of costimulation and IL-12, a Th1 immune response will develop and a relative control of the disease will be observed. Despite knowledge of the resistance and susceptibility in CBM, up to now, no effective vaccines have been developed. In the field of chemotherapy, most patients are treated with conventional antifungal drugs, such as itraconazole and terbinafine, but these drugs exhibit limitations, considering that not all patients heal cutaneous lesions. Few advances in treatment have been made so far, but one of the most promising ones is based on the use of immunomodulators, such as imiquimod. Data about a standard treatment are missing in the medical literature; part of it is caused by the existence of a diversity of etiologic agents and clinical forms. The present review summarizes the advances made in the field of CBM related to the diversity of pathogenic species, fungi and host cell relationship, antigens, innate and acquired immunity, clinical forms of CBM, chemotherapy, and diagnosis.

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“…Among the species most frequently associated with infections in humans are C. oxysporum (cutaneous phaeohyphomycosis with morphological identification), C. sphaerospermum (subcutaneous infection with ITS1-ITS4 molecular identification), C. herbarum (chronic rhinosinusitis with 18S rRNA molecular identification), C. macrocarpum (brain abscess with morphological identification), C. tenuissimum (chromoblastomycosis with ITS and D1/D2 and a D1/D2 domain of 26S rRNA molecular identification), and C. langeronii (chromoblastomycosis with ITS1-ITS4 molecular identification) [10][11][12][13][14]. Reports of C. cladosporioides infection in humans include cases of phaeohyphomycosis identified by morphological identification, keratomycosis with ITS1-18S rRNA molecular identification, pneumonia with morphological identification, rhinosinusitis with morphological identification, and, rarely, chromoblastomycosis with a D1/D2 domain of 26S rRNA molecular identification [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

From Child to Old Man: A Slowly Evolving Case of Chromoblastomycosis Caused by Cladosporium cladosporioides

Rodríguez-Cerdeira,

Hernández-Castro,

Arenas

et al. 2023

Antibiotics

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Chromoblastomycosis is a chronic granulomatous mycosis of the skin and subcutaneous tissue caused by traumatic inoculation with dematiaceous fungi. This disease primarily affects agricultural workers, who are mostly men. We present a case of chromoblastomycosis in a 63-year-old male farmer patient with dermatosis over 50 years of evolution, with warty, erythematous, and scaly plaques that predominate on the left hemithorax. Direct examination with potassium hydroxide (KOH) revealed numerous fumagoid cells. Amplification and sequencing of the internal transcribed spacer (ITS) and translation elongation factor 1-alpha (TEF-1a) gene revealed that chromoblastomycosis was caused by Cladosporium cladosporioides. The chromoblastomycosis was treated with itraconazole and fluconazole without any improvement, and amphotericin B was administered with partial improvement.

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Chromoblastomycosis due to Cladosporium langeronii. Molecular diagnosis of an agent previously diagnosed as Fonsecaea pedrosoi

Cited by 4 publications

References 4 publications

A case of chromomycosis due to Cladosporium halotolerans: Successful identification of previously unreported pathogen with a molecular approach

A case of chromomycosis due to Cladosporium halotolerans: Successful identification of previously unreported pathogen with a molecular approach

Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis

From Child to Old Man: A Slowly Evolving Case of Chromoblastomycosis Caused by Cladosporium cladosporioides

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