Cutaneous metastasis of colorectal cancer

Abstract

Cutaneous metastases from internal malignant neoplasms are a rare event and a late clinical finding that is associated with disseminated disease and a poor prognosis. Skin metastases from colon tumors occur in only 4% of cases of metastatic colorectal cancer. They are most often located on the abdominal skin. We report a case of 54-year-old male patient with a cutaneous metastatic focus on the lower abdomen as the initial presenting symptom of an underlying colon cancer.

Destination Unknown: A Unique Case of Metastatic Colorectal Carcinoma to the Breast, Axilla & Skin

“…Unlike skin metastases occurring in 24% of metastatic breast carcinomas, data suggests that cutaneous metastases occur in just 4% (2.3-6%) of colorectal carcinomas. They are mostly found on the skin of the abdominal wall, especially at the sites of surgical scars related to treatment of the primary tumour, as occurred in this case [6].…”

Unusual Cutaneous Metastases From Colon Adenocarcinoma

“…The clinical appearance of cutaneous metastasis can assume various morphologies. It usually presents as painless, red/flesh-coloured mobile nodules, single or multiple, but they can mimic other cutaneous processes like lipomas, epidermal cyst, polyps, ulcers, cellulitis, zona zoster [ 1 - 2 , 7 - 8 ]. The ultimate diagnosis of cutaneous metastasis from CRC relies on histological evaluation.…”

“…The ultimate diagnosis of cutaneous metastasis from CRC relies on histological evaluation. CK20, CDX2 and CK7 immunostaining are the most helpful markers to distinguish common malignancies, and CRC typically expresses CK20 and CDX2 but not CK7 [ 7 - 8 , 10 ].…”

“…Colorectal cancer (CRC) is one of the most frequently occurring cancers around the world, with 10% of them being diagnosed in stage IV [ 8 ]. The more common sites of metastasis are the liver, lung and central nervous system.…”

Facial cutaneous metastasis of rectal adenocarcinoma

“…Moreover, it should be differentiated from primary carcinoma of skin. Colorectal adenocarcinomas usually spread their metastases to the liver, peritoneum, pelvis, lung, and bone within the first 2 years after resection of the primary tumor [ 4 ]. Although skin metastasis of adenocarcinoma of the rectum is more rare, the most common site of skin metastasis is the middle or lower dermis of the abdomen and the perianal skin.…”