Serum uric acid levels and hyperuricemia in patients with psoriasis: a hospital-based cross-sectional study

Gui, Xinyu; Jin, Hongzhong; Wang, Zhen-Jie; Xu, Tianming

doi:10.1590/abd1806-4841.20187547

Cited by 18 publications

(20 citation statements)

References 9 publications

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“…These studies consisted of 31,314 participants (2,951 with psoriasis and 28,363 controls). The second part included seven studies ( 15 , 17 , 18 , 29 , 33 , 36 , 41 ) that had dichotomous hyperuricemia as the response variable. These studies included a total of 2,082 participants (958 with psoriasis and 1,124 controls) who met the inclusion criteria for the dichotomous variables of the systematic review.…”

Section: Resultsmentioning

confidence: 99%

“…The metaanalysis consisted of two parts based on the type of response variable. The first part included the 27 studies (10,11,(14)(15)(16)(17)(18)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) that used continuous SUA as the response variable. These studies consisted of 31,314 participants (2,951 with psoriasis and 28,363 controls).…”

Section: General Characteristics and Methodology Assessmentmentioning

confidence: 99%

“…In 2016, we reported a systematic evaluation of the relationship between psoriasis and SUA level ( 13 ). Psoriasis is associated with various disorders such as cardiovascular diseases ( 14 ), metabolic syndrome ( 15 , 16 ), obesity ( 17 , 18 ), and chronic obstructive pulmonary disease (COPD) ( 19 ). Shared inflammatory pathways and common risk factors, such as obesity, glycometabolism disorders, and lipid metabolism disorders, may explain the pathogenesis of comorbidities in patients with psoriasis ( 2 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

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Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Zhang

Liu

Sun³

et al. 2021

Front. Med.

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Background: Our earlier meta-analysis showed that the correlation between psoriasis and hyperuricemia might be region-dependent and that hyperuricemia was more common in patients with psoriasis in Western Europe. However, no further analysis could be conducted owing to the scarcity of data.Objective: Our study aimed to further explore the association between psoriasis and hyperuricemia.Methods: Six databases (PubMed, Embase, the Cochrane Central Register of Controlled Trials, the China National Knowledge Infrastructure database, the Chinese Scientific Journals Full Text Database, and the Wanfang Data Knowledge Service Platform) were searched for studies published between January 1980 and February 2021.Results: The search strategy yielded 291 relevant studies, of which 27 observational studies were included in this analysis. Serum uric acid (SUA) levels (mean difference [MD] 0.99, 95% confidence interval [CI] 0.48–1.49, P = 0.0001) and hyperuricemia frequency (odds ratio [OR] 5.39, 95% CI 1.88–15.40, P = 0.002) were higher in the psoriasis group than in the control group, and the subgroup differences were significant. In addition, SUA levels were significantly higher in patients with moderate to severe psoriasis from European and American countries (MD 0.89, 95% CI 0.18–1.60, P = 0.01) and Southeast Asia (MD 1.79, 95% CI 0.55–3.02, P = 0.004), while no significant differences were found between the Middle East subgroup (MD 0.63, 95% CI −0.33 to 1.59, P = 0.20). Similar results were obtained from the meta-analysis of SUA levels in patients with metabolic syndrome, obesity, or a special type of psoriasis (such as arthritic or erythrodermic psoriasis).Conclusions: Our meta-analysis study provides extended data regarding the correlation between psoriasis and hyperuricemia and the differences in SUA levels between psoriasis patients and controls in Southeast Asia, the Middle East, and European and American countries. Patients with moderate to severe psoriasis in European and American countries and Southeast Asia or those with metabolic syndrome and obesity were more likely to have higher uric acid levels.Systematic Review Registration: PROSPERO, identifier: CRD42014015091.

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Section: Resultsmentioning

confidence: 99%

Section: General Characteristics and Methodology Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Zhang

Liu

Sun³

et al. 2021

Front. Med.

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“…5 The hyperuricemia is basically serum uric acid ≥7 mg/dl for males and 6 mg/dl for females. 6 The mechanism through which hyperuricemia is associated with cardiovascular disease is unclear due to its relation with the established risk factor of diabetes mellitus, hypertension, and obesity etc. Elevated uric acid considered as one of the metabolic abnormalities associated with hyperinsulinemia which can be seen in NIDDM and impaired glucose intolerance.…”

Section: Introductionmentioning

confidence: 99%

Status of serum uric acid in diabetic and non-diabetic subjects.

Ahsan¹,

Fatima²,

Jahan³

et al. 2020

TPMJ

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Diabetes Mellitus is a chronic metabolic disorder which occurs due to absolute or relative deficiency of insulin hormone and the diabetic patients are more prone to develop stroke, heart attack, kidney failure, blindness, coronary artery disease, neuropathy and gangrene. Increased uric acid levels in serum are one of the metabolic abnormalities associated with diabetes mellitus type 2. Objectives: The purpose of the research is to assess the status of serum uric acid in non-diabetic and diabetic subjects. Study Design: Cross Sectional Comparative study. Setting: Department of Medicine Jinnah Postgraduate Medical Center, Karachi. Period: Feb 2018 till September 2018. Material & Methods: A total of 80 subjects of both sexes were taken and divided into two groups. Fasting glucose levels, serum uric acid were performed by enzymatic method. Results: This study showed significantly raised levels of serum uric acid and Fasting blood glucose (FBS) in diabetic type 2 subjects when compared to non-diabetic subjects(p<0.01). Conclusion: The results of the present study suggests that compared to non‐diabetic subject’s diabetic subjects have significantly higher level of uric acid.

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“…8 Gui et al reported that psoriatic patients without metabolic syndrome had significantly higher serum uric acid levels than controls and that psoriasis can be a strong predictor of hyperuricemia. 9 It is believed that NBUVB induced signaling leads to inhibition of nuclear factor kappa beta (NF-kB), and decreased production of interleukins, tumor necrosis factor-alpha (TNF-alpha), and interferongamma (IFN-gamma) which in turn decreases liver production of Acute phase reactant (APRs). 10 Although uric acid level was high in patients with psoriasis and its level significantly decreased with treatment, the change in uric acid level was not significantly correlated with the change in PASI score.…”

mentioning

confidence: 99%

Therapeutic implications of C‐reactive protein and uric acid in patients with psoriasis before and after narrow band ultraviolet B therapy

Shalaby

Elshahid

Metwaly

et al. 2020

Dermatologic Therapy

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Serum uric acid levels and hyperuricemia in patients with psoriasis: a hospital-based cross-sectional study

Cited by 18 publications

References 9 publications

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Status of serum uric acid in diabetic and non-diabetic subjects.

Therapeutic implications of C‐reactive protein and uric acid in patients with psoriasis before and after narrow band ultraviolet B therapy

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