Scanning electron microscopy of granuloma annulare

Abstract

Light microscopy of granuloma annulare shows mucin deposition with lympho-histiocytic infiltrate. We describe the ultrastructural three-dimensional aspects of a typical case of granuloma with characteristic histopathological findings. At the ultrastructural level, affected collagen bundles and granular mucin deposition were observed. Round cells corresponding to lymphocytes were identified. Bigger oval cells, corresponding to isolated or palisading histiocytes were also found. The ultrastructural aspects overlap with light microscopy and contribute to its iconographic documentation.

Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation

“…Furthermore, many spheres were found with 6-8 μm in diameter suggesting the presence of either granulocytes, lymphocytes or red blood cells inside the matrix close to the surface, which is understandable given that histopathology showed vascularization around these samples. Therefore, these are the most probable corpuscular elements (based on the literature) with comparable size with the ones found on the SEM images (Fig 8D) [49,50].…”