Atypical aquagenic keratoderma treated with oxybutynin chloride

Dixit, Niharika; Sardana, Kabir; Tandon, Sidharth; Singh, Yogita

doi:10.1590/abd1806-4841.20187262

Cited by 10 publications

(9 citation statements)

References 5 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Iontophoresis and botulinum toxin can alleviate symptoms in hPPK caused or exacerbated by water exposure 3. Although spontaneous remissions exist, in most cases aquagenic keratoderma (AqK) persists causing significant physical and psychological discomfort 28,29. AqK is characterized by transient whitish and translucent hyperwrinkling of palms and soles after water exposure, with a burning sensation, pain, pruritus and/or hyperhidrosis 29.…”

Section: Resultsmentioning

confidence: 99%

“…28,29 AqK is characterized by transient whitish and translucent hyperwrinkling of palms and soles after water exposure, with a burning sensation, pain, pruritus and/or hyperhidrosis. 29 Recently, familial cases of the autosomal dominant form of diffuse nonepidermolytic hPPK of Bothnian type, sharing clinical characteristics with AqK, have been shown to have mutations in the AQP5 gene encoding the cell membrane water-protein channel aquaporin 5. 30 Various treatment modalities have been used to improve AqK, including aluminium-based, urea or salicylic acid-based products, formalin 3% in alcohol, antihistamines, botulinum toxin injections and iontophoresis.…”

Section: Botulinum Toxinmentioning

confidence: 99%

“…30 Various treatment modalities have been used to improve AqK, including aluminium-based, urea or salicylic acid-based products, formalin 3% in alcohol, antihistamines, botulinum toxin injections and iontophoresis. [29][30][31] Dixit et al treated a 36-year-old man with oral oxybutynin chloride 2Á5 mg twice daily, and they noted a substantial amelioration of symptoms after water exposure in a patient who was resistant to topical 20% aluminium chloride but had a significant improvement using tap water iontophoresis. 29…”

Section: Botulinum Toxinmentioning

confidence: 99%

See 2 more Smart Citations

Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature*

et al. 2020

View full text Add to dashboard Cite

Summary Background No specific or curative therapy exists for hereditary palmoplantar keratoderma (hPPK), which can profoundly alter patient quality of life, leading sometimes to severe functional impairment and pain. The rarity and the aetiological diversity of this group of disorders can explain the difficulty in comparing the efficacy of available treatments. Objectives To review the different treatments tried in patients with hPPK since 2008, their efficacy and safety, with an evaluation of the various therapeutic modalities that can be used to treat hPPK. Methods We undertook a comprehensive review of the literature data published since 2008. Results Only a few case series and individual case reports were identified. Topical (emollients, keratolytics, retinoids, steroids) and systemic treatments (mostly different retinoids), often combined, are used to relieve symptoms. Oral retinoids appear to be the most efficient treatment, but not in all PPK forms, and with variable tolerance. New targeted treatments, according to the specific mechanisms of hPPK, appear promising for the future. Conclusions More studies using robust methodology and involving larger cohorts of well‐characterized patients (phenotype–genotype) are necessary and should be prioritized by structured networks, such as the European Network for Rare Skin Diseases (ERN‐Skin), with the aim of better management of patients with rare skin diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Botulinum Toxinmentioning

confidence: 99%

Section: Botulinum Toxinmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature*

et al. 2020

View full text Add to dashboard Cite

show abstract

“…aspecto vegetante se vuelve más notorio 26 . A la reproducibilidad de las lesiones tras la inmersión en el agua se le denomina «signo de las manos en cubeta» o «signo de las manos en balde», y se considera patognomónico 3 .…”

Section: B Aunclassified

“…En la mayoría de los pacientes, la dermatosis tiende a la cronicidad, aunque excepcionalmente algunos presentan remisión espontánea 4 . Se han utilizado diversos tratamientos, como queratolíticos con urea y ácido salicílico 6 , oxibotunina 26 , toxina botulínica 27,28 y cloruro de aluminio, con resultados variables y recurrencias tras la suspensión. El cloruro de aluminio se mezcla con el sudor y, al difundirse por el conducto sudoríparo, reacciona con los componentes del sudor (iones hidróxido, sales de ácido láctico y proteínas) formando especies insolubles de hidróxido de aluminio, lo que produce un bloqueo del acrosiringio distal que conduce a la degeneración funcional y estructural de las células secretoras de la glándula ecrina 29 .…”

Section: B Aunclassified

Queratodermia acuagénica

Marín-Hernández¹,

García-Alonso²,

Cruz-Flores³

et al. 2022

BMHIM

View full text Add to dashboard Cite

Introducción: La queratodermia acuagénica se desencadena tras el contacto de las palmas de las manos y las plantas de los pies con el agua. Se caracteriza por la aparición de pápulas translúcidas que forman placas de aspecto macerado. Puede asociarse con el consumo de ciertos medicamentos y con afecciones como la fibrosis quística, la atopia y la desnutrición, o ser idiopática. Caso clínico: Se describe el caso de una paciente de 17 años con dolor abdominal crónico funcional. Presentó una dermatosis de 2 meses de evolución que afectaba las palmas con «arrugamiento» después del contacto con el agua. Tras el estímulo con el agua, se observaron hiperlinealidad palmar y pápulas blanquecinas y translúcidas que formaban placas de aspecto macerado con una depresión central. Dermatoscópicamente se observaron estructuras blanquecinas anfractuosas de apariencia coraliforme y microgotas de agua. En el estudio histológico se observaron hiperqueratosis continua y dilatación del acrosiringio desde la dermis media hasta el estrato córneo. Con el cuadro clínico y los hallazgos histológicos, se confirmó el diagnóstico de queratodermia acuagénica y se inició el tratamiento, con el que se observó una mejoría parcial. Conclusiones: La queratodermia acuagénica es una afección subdiagnosticada y poco reportada. A pesar de cursar de forma indolente, puede considerarse como un marcador de enfermedad sistémica como la fibrosis quística. Ya que existe discusión sobre la nomenclatura de la enfermedad, consideramos ajustarnos a una nomenclatura descriptiva, como «placas blanquecinas y maceradas acuagénicas del acrosiringio». Es necesario continuar reportando estos casos para comprender mejor la enfermedad, ofrecer un manejo adecuado y dar seguimiento integral a los pacientes.

show abstract

Whitish Translucent Papules and Plaques on Fingers and Palms

Wollina

2020

Clinical Cases in Pigmentary Disorders

View full text Add to dashboard Cite

Atypical aquagenic keratoderma treated with oxybutynin chloride

Cited by 10 publications

References 5 publications

Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature*

Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature*

Queratodermia acuagénica

Whitish Translucent Papules and Plaques on Fingers and Palms

Contact Info

Product

Resources

About