Clinical and epidemiological profile of patients with early stage mycosis fungoides

Abstract

BackgroundMycosis fungoides is the most common form of primary cutaneous lymphoma, with an indolent, slowly progressive course and 88% five-year survival rate. The diagnosis is challenging, especially in the early stages, and usually relies on a good clinical-histopathological correlation.ObjectiveThe aim was to establish the clinical and epidemiological profile of patients with early-stage mycosis fungoides.MethodsThis was a retrospective cross-sectional observational study with an exploratory analysis. Outcome variables were disease progression and mycosis fungoides-related death.ResultsOne hundred and two patients were included. The majority were white males, with a mean age of 55.6 years. Mean time from onset of lesions to diagnosis was 51.08 months. The majority of patients were classified as IB stage according to TNMB. Mean follow-up time was 7.85 years. Disease progression was seen in 29.4% of the patients. Death related to the disease occurred in 7.9% of patients. Plaque lesions, involvement of more than 10% of the body surface, altered lactate dehydrogenase and beta-2-microglobulin, and stage IB were significantly associated with disease progression, and altered lactate dehydrogenase and beta-2-microglobulin also correlated with higher frequency of deaths.Study limitationsSmall sample and retrospective design.ConclusionsThe clinical and epidemiological profile of patients with early-stage mycosis fungoides in our sample corroborates reports in the literature. Diagnostic delay in our series is also consistent with previous findings, but the rate of disease progression, despite treatment, was higher than reported in the literature.

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

“…In line with the literature, the majority (64.8%) of our study group were aged between 50 and 79 years [2,3]. However, in contrast to previous studies the number of females in our MF cohort outnumbered the males (51% vs. 49%) [2,3,[14][15][16]. Concordant with earlier observations, we found that Caucasians were most commonly affected, constituting 56.1% of our patient cohort [2,8,17].…”

Demora en el diagnóstico de los linfomas cutáneos primarios

“…Por otro lado, estas lesiones son difíciles de diferenciar de otras anomalías como el eccema, incluso para los propios dermatólogos, lo que aumenta el tiempo transcurrido hasta la derivación. Es frecuente que los pacientes se sometan a más de una biopsia hasta determinar el diagnóstico definitivo, debido a patrones inespecíficos en estadios tempranos de la enfermedad [10][11][12][13][14][15] .…”

Gamma-delta mycosis fungoides in a posttransplant patient

“…2 MF typically has an indolent growth phase with an estimated 88% 5-year survival rate. 4 The World Health Organization/ European Organisation for Research and Treatment of Cancer classification for primary cutaneous lymphomas defines multiple subtypes of MF, including classic plaque-stage MF, folliculotropic MF, pagetoid reticulosis, and granulomatous slack skin. The gd subtype is a rare subtype of MF and is characterized by the expression of the gd T-cell receptor (TCRgd).…”