Kaposi’s sarcoma in persons living with HIV/AIDS: a case series in a tertiary referral hospital

Abstract

BackgroundKaposi’s sarcoma (KS) is a rare neoplasm with indolent progression. Since 1981, the Kaposi’s sarcoma epidemic has increased as co-infection with HIV.ObjectivesThe study aimed to identify the clinical and demographic characteristics and therapeutic approaches in HIV/AIDS patients in a regional referral hospital.MethodsWe analyzed the medical records of 51 patients with histopathological diagnosis of Kaposi’s sarcoma hospitalized at Hospital Universitário João de Barros Barreto (HUJBB) from 2004 to 2015.ResultsThe study sample consisted of individuals 15 to 44 years of age (80.4%), male (80.4%), single (86.3%), and residing in Greater Metropolitan Belém, Pará State, Brazil. The primary skin lesions identified at diagnosis were violaceous macules (45%) and violaceous papules (25%). Visceral involvement was seen in 62.7%, mainly affecting the stomach (75%). The most frequent treatment regimen was 2 NRTI + NNRTI, and 60.8% were referred to chemotherapy.Study limitationsWe assumed that more patients had been admitted to hospital without histopathological confirmation or with pathology reports from other services, so that the current study probably underestimated the number of KS cases.ConclusionAlthough the cutaneous manifestations in most of these patients were non-exuberant skin lesions like macules and papules, many already showed visceral involvement. Meticulous screening of these patients is thus mandatory, even if the skin lesions are subtle and localized.

Manifestações odontológicas prevalentes em soropositivos para o HIV: revisão de literatura

“…Este sarcoma é um tumor vascular multicêntrico causado pelo herpes vírus humano 8 (HHV-8) que se desenvolve nos tecidos como a pele, cartilagem, o osso, a gordura, o músculo, os vasos sanguíneos, ou os tecidos fibrosos. É uma doença agressiva que pode gerar complicações, podendo ser fatal (Pires et al, 2018). As lesões cutâneas de SK são tipicamente nodulares, pigmentadas, indolores, de tamanhos variáveis, que podem ir de milímetros a placas tumorais confluentes de 5 a 10 cm de diâmetro e de fácil reconhecimento (Ferreira, 2016).…”