A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients

Aly, Dalia Gamal; Salem, Samar Abdallah Mohamed; Amr, Khalda; El-Hamid, M. F. Abd

doi:10.1590/abd1806-4841.20185796

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…However, the investigational studies reported here allow to extrapolate some useful observations. For instance, the simultaneous absence of both GST-T1 and GST-M1 enzymes has been shown by many authors as having a negative effect on vitiligo populations (Aly et al 2018). The high frequency of the double-null genotypes found in different ethnicities further corroborates the association between enzyme deficiency and vitiligo risk (Park et al 2016).…”

Section: Discussionmentioning

confidence: 82%

“…In a study conducted on 122 vitiligo Egyptian patients and 200 healthy controls, age-and gender-matched, the authors found a significant trend towards the combination of the GST-M1/GST-T1 double-null polymorphism and generalized vitiligo. Individuals with GST-M1-null and GST-T1-positive heterozygosis showed a 2.97 odd ratio (OR) protection from having generalized vitiligo compared with vitiligo patients (Aly et al 2018). In another study, genotyping by multiplex PCR of GST-M1 and GST-T1 in 101 Egyptian women with nonsegmental vitiligo vulgaris and 101 age female healthy matched controls show that the absence of GST-M1 gene and the presence of the GST-M1/GST-T1 double-null genotype represent a risk factor for vitiligo in these women (p = 0.01; OR = 2.694) (Bassiouny and Khorshied 2012).…”

Section: Glutathione S-transferasementioning

confidence: 99%

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Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

Chiarella

2019

biomed dermatol

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Objective: Vitiligo is a frequently underestimated and little known dermal disease whose symptoms appear as white patches on several skin areas of the body. In this review, the impact of idiopathic and chemical-induced vitiligo at workplace and in daily life is discussed. Also, the influence of selected oxidative stress gene polymorphisms on melanocyte damage is described to understand their involvement in the disease. Methods: A PubMed search was carried out to select the journal articles reporting an association between specific oxidative stress polymorphic genes and vitiligo. Results: The double-null glutathione S-transferase T1 and M1 genotypes are associated with vitiligo while the relationship between nuclear factor erythroid 2-related factor 2, heme oxygenase, catalase and superoxide dismutase gene polymorphisms and the disease should be confirmed by further studies. Conclusions: The polymorphic genes analysed here may have a role in the susceptibility of patients affected by vitiligo, while little is known about the affected workers, due to the lack of epidemiologic data on these subjects. However, the similarity of the skin lesions observed in both groups might have in common some genetic factors making all these individuals susceptible to the development of vitiligo, regardless of the disease-triggering factor.

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Section: Discussionmentioning

confidence: 82%

Section: Glutathione S-transferasementioning

confidence: 99%

Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

Chiarella

2019

biomed dermatol

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“…A large number of genes encode proteins that are involved in immune regulation, cellular apoptosis, and the regulation of the functions of melanocytes. Some studies have implicated the role of genetic polymorphism in vitiligo, such as single-nucleotide polymorphisms (SNPs), nucleotide insertions, deletions, inversions, and chromosomal translocations [ 13 , 14 ]…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Reversal of Vitiligo, a Rare Phenomenon Reported in a Case in Saudi Arabia with an Insight into Metabolic Biochemical Derangements

Alshaikh

Bharti

2023

Medicina

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Background and Objectives: Vitiligo is a skin disorder characterized by hypopigmented macules occurring due to melanocyte destruction. An interplay of several biochemical mechanisms has been proposed to explain the etiopathogenesis of vitiligo, such as genetic, autoimmune responses, generation of inflammatory mediators, oxidative stress, and melanocyte detachment mechanisms. There is no cure for vitiligo; however, pharmacological treatment measures (cosmetic camouflage creams, steroids, psoralen and ultraviolet A (PUVA) therapy, narrowband UVB) are available, but they could have certain side effects. We reported an interesting case of vitiligo in Saudi Arabia that showed reversal of vitiligo, which is an extremely rare phenomenon, with the objective of probing the probable reasons for this reversal. To the best of our knowledge, there is no study on vitiligo that has reported spontaneous reversal of vitiligo in Saudi Arabia so far. Materials and Method: The patient presented to the Family Medicine clinic with a history of restoration of melanin pigment in his lesions after 3 years of the onset of vitiligo. Patients history was taken carefully along with clinical examination, carried out necessary biomedical lab investigations and compiled the data. The data at the time of pigment restoration were compared to the previous data when he developed the lesions. Result: The probable reasons for vitiligo reversal could be markedly decreased psychological stress, regular consumption of an antioxidant-rich herbal drink made of curcumin and honey, and dietary switchover to vegetarianism and an alcohol-free lifestyle. Conclusions: Curcumin-based herbal remedies could be an alternative option to treat vitiligo. These methods must be further explored through clinical trials as they are safer, easily available, and more affordable.

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“…To annul confounding effects of medicines, all children were compliant on iron chelation, and all were on regular blood transfusions. We relied upon historical Egyptian control group for comparison (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Detoxification Genomics in Children with β-Thalassemia Major: Pilot Study of Glutathione S Transferase M1, Pi & Methyltetrahydrofolate Reductase Gene Polymorphisms Combinations in β- Thalassemia Major

Kotb

Hamdy

Eid

et al. 2021

Pediatric Sciences Journal

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Background: Children with β-thalassemia major differ regarding age at presentation, transfusion requirements and unpredictable timing, rate and severity of hemolytic crisis. The blood transfusions are associated with iron overload. Glutathione S transferase M1 (GSTM1) null mutation was reported to be associated with myocardial iron overload with low body iron. Aim of the Work:To investigate if children with β-thalassemia major have more than a detoxification enzyme defect. Materials and Methods: GSTM1, glutathione S transferase Pi (GSTPi) and methyltetrahydrofolate reductase (MTHFR) polymorphism were studied among 97 children with β-thalassemia major in a cross-sectional study. Results: The studied cohort comprised 24 (24.7%) girls and 73 (75.3%) boys. Mean hemoglobin was 5.9+/-0.7gm%, serum iron was 145.69 +/-58.6 mcg% and total iron binding capacity was 222.58 +/-50.66 mcg%. Of them, 68 (70.1%) demonstrated single or multiple polymorphisms (43 had GSTM1, 20 GSTPi and 32 with MTHFR polymorphisms respectively), while 29 (29.2%) did not demonstrate any polymorphism. There was no correlation between type, number of polymorphisms and clinical phenotype. Sample size and cross-sectional nature of our study did not allow genotype-phenotype correlation. Most of studied children express GSTM1, GSTPi and MTHFR gene polymorphism which was not consistent among them. Conclusion:Children with β-thalassemia major may have one or more than a detoxification/ regeneration potential enzyme gene GSTM1, GSTPi and MTHFR polymorphism. Every child with β-thalassemia major has unique genetic detoxification and regeneration abilities. The detected detoxification defects might explain the lack of predictability of occurrence of hemolytic attacks and their severity. More studies are needed to highlight impact of detoxification and regeneration genomics in β-thalassemia.

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A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients

Cited by 6 publications

References 12 publications

Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

Vitiligo susceptibility at workplace and in daily life: the contribution of oxidative stress gene polymorphisms

Spontaneous Reversal of Vitiligo, a Rare Phenomenon Reported in a Case in Saudi Arabia with an Insight into Metabolic Biochemical Derangements

Detoxification Genomics in Children with β-Thalassemia Major: Pilot Study of Glutathione S Transferase M1, Pi & Methyltetrahydrofolate Reductase Gene Polymorphisms Combinations in β- Thalassemia Major

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