Piccardi-Lassueur-Graham-Little syndrome associated with frontal fibrosing alopecia

Griffiths, Andrea Alejandra Catalán; Sancho, Maribel Iglesias; Plaza, Ana Iglesias

doi:10.1590/abd1806-4841.20176741

Cited by 5 publications

(4 citation statements)

References 9 publications

(7 reference statements)

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“…Frontal fibrosing alopecia is a variant of LPP that affects the anterior scalp, forehead and eyebrows. Another subtype of LPP is Graham-Little-Piccardi-Lasseur Syndrome with the following characteristics: multifocal, patchy, cicatricial alopecia present on the scalp, non-cicatricial alopecia of the axillae, non-cicatricial alopecia of the perineum, and follicular hyperkeratosis of the trunk and extremities ( 106 ).…”

Section: Diagnosismentioning

confidence: 99%

Lichen Planus

et al. 2021

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Lichen planus (LP) is a T cell-mediated disease affecting the stratified squamous epithelia of the skin and/or mucus membrane. Histologically, the disease is characterized by a lichenoid inflammatory infiltrate and vacuolar degeneration of the basal layer of the epidermis. LP has three major subtypes: Cutaneous, mucosal and appendageal LP. Rarely, it may affect the nails in the absence of skin and/or mucosal changes. LP may also be induced by several drugs, typically anti-hypertensive medication or be associated with infections, particularly viral hepatitis. The diagnosis is based on the clinical presentation and characteristic histological findings. Although the disease is often self-limiting, the intractable pruritus and painful mucosal erosions result in significant morbidity. The current first-line treatment are topical and/or systemic corticosteroids. In addition, immunosuppressants may be used as corticosteroid-sparing agents. These, however are often not sufficient to control disease. Janus kinase inhibitors and biologics (anti-IL-12/23, anti-IL17) have emerged as novel future treatment options. Thus, one may expect a dramatic change of the treatment landscape of LP in the near future.

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Section: Diagnosismentioning

confidence: 99%

Lichen Planus

et al. 2021

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“…Graham Little‐Piccardi‐Lassueur syndrome is a rare subtype of lichen planopilaris, characterized by a triad of follicular spinous papules on the body, scarring alopecia of the scalp, and non‐scarring alopecia of the axillary and pubic region. Features were multiple round‐to‐oval yellowish areas with keratotic follicular plugs, surrounded by mild erythema 81,82 . Yellow dots were noted on the pubis and axilla, along with isolated exclamation mark hair 81 …”

Section: Other Body Hairsmentioning

confidence: 99%

“…Features were multiple round-to-oval yellowish areas with keratotic follicular plugs, surrounded by mild erythema. 81,82 Yellow dots were noted on the pubis and axilla, along with isolated exclamation mark hair. 81…”

Section: Scurvymentioning

confidence: 99%

Trichoscopy beyond scalp. A narrative review

Shakshouk

Tosti

2022

Int J Dermatology

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Dermoscopy is becoming an indispensable tool in everyday practice, with an expanding range of applications. Trichoscopy is effective not only in establishing the diagnosis of scalp disorders but also in the follow-up of treatment. The MEDLINE database was searched using the terms "dermoscopy" and "trichoscopy" in combination with each of the following: "axilla," "pubic area," "beard," "eyebrows," "eyelashes," and "body hairs." We included case reports, case series, and review articles mentioning the previous terms. By providing an updated review from the literature, we aimed to emphasize the potential uses of trichoscopy in detecting diseases in hairy locations other than the scalp. Various inflammatory conditions, infections, and infestations are discussed.

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“…Disrupted vascular plexus with dilated or elongated blood vessels is due to inflammation 2 . The association of GLPLS and FFA 3 lead us to speculate that GLPLS, FFA, and LPP might be different manifestations of a disease with a wider spectrum of clinical presentation. A full body examination is necessary in any case of suspected LPP in order to avoid missing GLPLS as many patients might not refer the other manifestations.…”

Section: Figurementioning

confidence: 99%