S-100 negative myxoid neurothekeoma: a new type of neurothekeoma?

Abuawad, Yasmin Gama; Saraiva, Maria Isabel Ramos; Westin, Andrezza Telles; Valente, Neusa Yuriko Sakai

doi:10.1590/abd1806-4841.20176016

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…It has been interesting to confirm that all previously mentioned histopathological features since 1980 when the terminology of NTK has been first introduced by Gallager and Helwig were still observed [1, 5]. Different reports have shown that NTK is consistently negative with S-100 in comparison to the NSM cases [6, 7]. Page in 2004 studied 11 cases to characterize the combination of MiTF and NKI/C3 expression in cellular NTK.…”

Section: Discussionmentioning

confidence: 89%

“…IHC stains for NKI/C3 and CD-10 are useful ancillary tests for the diagnosis of cellular NTK if used in combination to histopathological features. Also, in cases of S-100 negative neurothekeoma of the myxoid type, fibro-histiocytic markers are to be considered such as CD-68 [6, 9, 10]. The diﬀerential diagnosis in the reviewed cases included neurothekeoma (23′) melanocytic tumor variants (especially a Spitz nevus), neuroﬁbroma, schwannoma/neuroma variant, ﬁbro-histiocytic tumor, and NSM.…”

Section: Discussionmentioning

confidence: 99%

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Unusual Recurrent Lateral Canthus Mass in a 16-Year-Old Male Patient: Neurothekeoma

et al. 2019

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Neurothekeoma (NTK) is a specific benign soft tissue tumor, typically involving the skin of the head and neck area as well as the upper part of the body in young age with female predominance. It has a typical lobular pattern of growth but often displays atypical features such as myxoid stroma or fascicular pattern, which makes the diagnosis more difficult and may necessitate the use of immunohistochemical staining to differentiate NTK from nerve sheath tumor. Ocular NTK in general is very rare with only 11 cases previously reported. We are presenting a case of recurrent mixed cellular/myxoid NTK involving the lateral canthal area of a 16-year-old-boy and we demonstrate the diagnostic challenge in such cases to attract the attention of ophthalmologists and pathologist to the rare occurrence of NTK in the ocular region.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Unusual Recurrent Lateral Canthus Mass in a 16-Year-Old Male Patient: Neurothekeoma

et al. 2019

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“…NTKs were initially considered to be neurogenic tumours originating from Schwann cells, and NTKs were diagnosed and reported for many years as one of the subtypes of dermal nerve sheath myxomas[ 6 ]. Recently, studies have shown that, unlike DNSMs, NTKs do not express the S-100 protein[ 7 ]. Further analysis of gene expression profiles shows that DNSMs are similar to schwannomas, while NTKs show evidence of myofibroblastic differentiation and possible relation to dermatofibromas[ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Neurothekeoma located in the hallux and axilla: Two case reports

Huang¹,

Zhang²

2022

WJCC

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BACKGROUND Neurothekeomas (NTKs) are rare benign soft tissue tumours that typically occur in the head, trunk, and upper limbs and are rare in other parts of the body. CASE SUMMARY Herein, we present two rare cases in which primary NTKs were located in the hallux and axilla. A 47-year-old woman complained of a verrucous bulge on the plantar side of the left hallux. The surface skin of the tumour was abraded due to poor wound healing. A 6-year-old boy complained of a gradually growing subcutaneous mass in the axilla. The tumours of both patients were completely resected, and the diagnosis of NTK was confirmed by histopathology. At the one-year follow-up, both patients had a good prognosis without local recurrence. CONCLUSION To date, NTKs located in the hallux and axilla have rarely been reported in the literature. We describe NTKs that occurred in unconventional areas and summarize the challenges in their diagnosis and differential diagnosis.

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Cellular neurothekeoma of the eyelid: A rare tumor with a common clinical presentation

Ojha,

Verma,

Srivastava

et al. 2024

Indian Journal of Ophthalmology - Case Reports

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We report a case of cellular neurothekeoma (NTK) in a 4-year-old male boy, which presented as a painless, progressive, left upper lid mass of 6 months’ duration. The left upper lid mass was solitary and dome shaped, causing mechanical ptosis. A magnetic resonance imaging (MRI) was performed followed by surgical excision of the mass in two stages, which, after histopathology and immunohistochemistry, was confirmed to be cellular NTK with no recurrence reported so far. To our knowledge, cellular NTK (a variant of NTK), an uncommon benign skin neoplasm involving the ocular adnexa (eyelid), is extremely rare. It is important to differentiate it from other malignant lesions, so that aggressive treatment can be avoided. The treatment of choice in cellular NTK is complete excision with clear margins.

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S-100 negative myxoid neurothekeoma: a new type of neurothekeoma?

Cited by 3 publications

References 5 publications

Unusual Recurrent Lateral Canthus Mass in a 16-Year-Old Male Patient: Neurothekeoma

Unusual Recurrent Lateral Canthus Mass in a 16-Year-Old Male Patient: Neurothekeoma

Neurothekeoma located in the hallux and axilla: Two case reports

Cellular neurothekeoma of the eyelid: A rare tumor with a common clinical presentation

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