The role of intradermal proliferation of T-cells in the pathogenesis of psoriasis

Abstract

BACKGROUNDPsoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph nodes and their subsequent migration into the skin through the blood system. Here we provide evidence that psoriatic plaque itself may serve as a source of inflammatory T-cells.OBJECTIVEWe examined the intradermal proliferation of T-cells and the number of effector/memory (CD45RO+) T-cells in the skin of psoriatic patients at different periods of the disease.METHODSSkin samples were obtained from 41 patients with progressive psoriatic lesions; 18 of these patients also donated skin specimens during the remission of the disease. The control group consisted of 16 healthy subjects. Ki-67 immunohistochemical staining was applied to detect proliferating cells, CD3ε served as a T-cell marker, and CD45RA and CD45RO antibodies were utilized to discriminate between naive and effector/memory T-cells, respectively.RESULTSProgressive psoriatic lesions demonstrated Ki67 staining both in keratinocytes and in the CD3ε+ cells of dermal infiltrate. Median count of CD45RO+ cells per microscopic field was 15 in healthy controls, 59 in patients in remission and 208 in progressive psoriatic plaques. The observed differences demonstrated high level of statistical significance.STUDY LIMITATIONSLimited number of analyzed patients.CONCLUSIONProgressive phase of psoriasis is characterized by intradermal proliferation of T-cells. Spots of regressed psoriatic lesions contain high number of CD45RO+ cells, which are likely to render an immunological memory.

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

“…70,[72][73][74] (3) The memory CD45RO + CLA À T cells are accompanied by the T h 1 and T h 17 cells to be carried out through the blood vessels from the dermis to the epidermis as the result of the intradermal proliferation of T-cells. 74 (4) In the epidermis, the natural killer T cells are responsible for direct antigen presentation due to their proximity to the keratinocytes. The activated T h 1 cells are stimulated by IL-18 and IL-23 to secrete interferon-gamma (IFN-g) cytokine.…”

“…(3) The memory CD45RO + CLA − T cells are accompanied by the T h 1 and T h 17 cells to be carried out through the blood vessels from the dermis to the epidermis as the result of the intradermal proliferation of T-cells. 74 …”

Curcumin reduces inflammation in mice with the psoriasis model by inhibiting NLRP3 inflammatory bodies

“…Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratinocytes mediated by the immune system. During this process, dendritic cells are activated, releasing pro-inflammatory factors, and then recruiting T cells to the skin lesions (17). Clinically, psoriasis vulgaris is the most common type.…”

South Ural state medical University, Department of Dermatovenerology

“…Врожденный иммунный ответ миндалин может играть решающую роль в инициации и последующем регулировании Т-клеточно-опосредованного адаптивного иммунного ответа. Таким образом, аномальные реакции миндалин на стрептококковую инфекцию могут привести к увеличению Т-клеток и воздействию их на кожу, где они индуцируют воспалительную реакцию, обостряющую псориатическое воспаление [14,[23][24][25]. Установлена роль β-гемолитического стрептококка как инфекционного агента, приводящего к возникновению каплевидного псориаза, наиболее часто встречающегося в педиатрической практике [12,14,24].…”