Diabetes mellitus and the skin

Mendes, Adriana Lúcia; Miot, Hélio Amante; Haddad, Vidal

doi:10.1590/abd1806-4841.20175514

Cited by 60 publications

(76 citation statements)

References 102 publications

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“…Contudo, devido à sua relação significativa com o diagnóstico de DM (75-90% dos doentes com NL tem ou irá desenvolver DM tipo 1), pensa-se que sua origem pode estar relacionada a uma microangiopatia [1][2][3]12]. A NL é então considerada uma das formas de dermatose que ocorrem em associação com DM [3,5,13].…”

Section: Discussionunclassified

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Necrobiose lipoídica em adolescente com diabetes mellitus tipo 1: relato de caso

Gomes

Laranjo

Campos

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACTAIMS: To report a case of necrobiosis lipoidica, a rare chronic granulomatous dermatosis. CASE DESCRIPTION: We present the case of a 17-year-old male adolescent, with type 1 diabetes mellitus from the age of four, followed in the Pediatric-Diabetology clinics of a level II hospital, under intensive regimen with multiple insulin administrations and poor metabolic control. At the age of 15, he noticed the appearance of an asymptomatic, erythematous, infiltrated, oval-shaped plaque, with a waxy whitish center, well-defined borders, 5 cm in diameter and progressive growth, located on the left forearm. The histological examination confirmed the diagnosis of necrobiosis lipoidica. He was treated with topical corticosteroid and emollient, thus stabilizing and reducing lesion infiltration. CONCLUSIONS: The authors highlight a rare dermatosis, non-pathognomonic of diabetes mellitus but related to this diagnosis in most cases. Its challenging recognition, especially in the presence of recent onset lesions, with atypical clinical presentation or in unusual sites, is fundamental in order to avoid erroneous or late treatments and its progression to ulceration.

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Section: Discussionunclassified

“…Estudos prévios demonstraram que o prognóstico da NL parecia ser independente do curso da DM e que o controle glicêmico estaria relacionado com o início e a gravidade da lesão [1,13]. Contudo, novos estudos já começam a estabelecer uma relação entre a existência de um mau controle metabólico e o desenvolvimento de NL.…”

Section: Discussionunclassified

Necrobiose lipoídica em adolescente com diabetes mellitus tipo 1: relato de caso

Gomes

Laranjo

Campos

et al. 2017

Sci Med

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“…Dermatology Some skin conditions may be an indicator of the presence of T2D in children and adolescents. The most common of these is acanthosis nigricans (AN), which is skin hyperpigmentation affecting the armpits, neck folds, flexor skin muscles, and umbilicus [19][20][21] (Fig. 1).…”

Section: Less-known Comorbid Associations With Youth-onset T2dmentioning

confidence: 99%

“…Other diabetes-associated dermatological conditions are rare in children, but could be warning indicators. These include granuloma annulare [21,22], necrobiosis lipoidica diabeticorum [20][21][22], and scleredema [20]. Granuloma annulare consists of small circular patches of pink/purple skin, up to 5 cm in diameter, and necrobiosis lipoidica diabeticorum causes yellowbrown skin plaques with an atrophied center [22].…”

Section: Less-known Comorbid Associations With Youth-onset T2dmentioning

confidence: 99%

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Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises

2019

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Background: Youth-onset type 2 diabetes (T2D) is increasing in many countries, creating large personal and societal burdens. While many primary health-care professionals (HCPs) are aware of the classic symptoms of T2D, there are several other manifestations that could indicate its presence. Summary: This narrative review summarizes information on these symptoms and indicators, focusing on those less well known. The classic symptoms and comorbidities include frequent urination, excessive thirst, metabolic syndrome, and obesity. In addition to these, the presence of dermatological (e.g., acanthosis nigricans, granuloma annulare, necrobiosis lipoidica diabeticorum, and scleredema), gynecological (e.g., polycystic ovary syndrome, oligomenorrhea, and vulvovaginitis), hepatological (e.g., nonalcoholic fatty liver disease), and psychiatric diseases (e.g., psychosis, depression, and autism) could indicate that a patient has T2D or is at increased risk of T2D. Other less well-known indicators include abnormal blood tests (e.g., oxidized lipids, inflammation markers, hepatokines, and adipokines), prescriptions for antipsychotic medications or statins, and disrupted sleep patterns. Key Message: Due to the diversity of T2D manifestations in young people, primary HCPs need to remain alert to its possible presence.

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The Skin in Diabetes

Yesudian

2024

Textbook of Diabetes

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Diabetes mellitus and the skin

Cited by 60 publications

References 102 publications

Necrobiose lipoídica em adolescente com diabetes mellitus tipo 1: relato de caso

Necrobiose lipoídica em adolescente com diabetes mellitus tipo 1: relato de caso

Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises

The Skin in Diabetes

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