Anti-neutrophil cytoplasmic antibodies in new-onset systemic lupus erythematosus

Su, Fang; Xiao, Weiguo; Yang, Pingting; Chen, Qingyan; Sun, XiaoJie; Li, Tienan

doi:10.1590/abd1806-4841.20175476

Cited by 13 publications

(11 citation statements)

References 16 publications

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“…In our study, 33 of the 111 SLE children were positive for ANCA, with a positive rate of 29.7%, which was consistent with the previous reports. The relationship between positive ANCA and pulmonary involvement has also reported in previous studies, especially in adult patients ( 20 , 22 ). Therefore, when the children with SLE is found to have positive ANCA, it should be alert to the occurrence of pulmonary involvement.…”

Section: Discussionsupporting

confidence: 77%

“…The discovery of ANCA helped establish ANCA-associated vasculitis as a separate and well-defined clinical entity ( 18 , 19 ). Previous studies reported that the positive rate of ANCA in patients with SLE ranges from 25 to 69% ( 20 – 22 ). In our study, 33 of the 111 SLE children were positive for ANCA, with a positive rate of 29.7%, which was consistent with the previous reports.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Involvement in Children With Systemic Lupus Erythematosus

Dai

Wang

et al. 2021

Front. Pediatr.

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Background: Symptomatic pulmonary involvement in systemic lupus erythematosus (SLE) seems not uncommon in children. However, there are few data on the characteristics and laboratory parameters of SLE patients with pulmonary involvement.Methods: This was a hospital-based study involving 111 SLE patients from 1 January 2012 to 31 December 2016. The demographic, clinical, and laboratory data of the patients were prospectively collected. They were followed as outpatients until December 2019. Clinical characteristics and laboratory parameters of patients with and without pulmonary involvement were compared.Results: Of the 111 patients with SLE, we identified 18 patients (16.2%) with pulmonary involvement. The most common HRCT findings were ground glass opacity, interlobular septal thickening, bilateral diffuse infiltrates, and pleurisy/pleural effusion (55.6, 50, 50, and 44.4%, respectively). SLE patients with pulmonary involvement tended to have a longer disease duration (14 [12–24.5] vs. 5 [2–9] months, P < 0.01). We also observed a significant association between the presence of anti-Sm antibody, ANCA, Anti-RNP and the presence of pulmonary involvement of SLE (all P < 0.001).Conclusions: Lung involvement was frequent in SLE patients from Southeast China. Patients with a longer duration of symptoms before SLE diagnosis tended to have pulmonary involvement. When children with SLE are found to have anti-RNP antibody and positive ANCA, it should be alert to the occurrence of pulmonary involvement.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Pulmonary Involvement in Children With Systemic Lupus Erythematosus

Dai

Wang

et al. 2021

Front. Pediatr.

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“…In our study, 33 of the 111 SLE children were positive for ANCA, with a positive rate of 29.7%, which was consistent with the previous reports. The relationship between positive ANCA and pulmonary involvement has also reported in previous studies, especially in adult patients 20,22 . Therefore, when the children with SLE is found to have positive ANCA, it should be alert to the occurrence of pulmonary involvement.…”

Section: Discussionsupporting

confidence: 76%

Pulmonary manifestations in children with systemic lupus erythematosus

Jiang

Dai

Wang

et al. 2020

Preprint

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Background Symptomatic pulmonary involvement in systemic lupus erythematosus (SLE) is commonly reported in children. However, few studies have assessed risk factors that predict pulmonary involvement in SLE.Methods This was a seven-year retrospective study involving 111 SLE patients. The demographic, clinical and laboratory data of the patients were collected. Logistic regression analysis was performed to identify different clinical characteristics and laboratory parameters associated with presence of high resolution computerized tomography(HRCT) chest abnormalities.Results Of the 111 patients with SLE, we identified 18 patients (16.2%) with pulmonary involvement. The most common HRCT findings were ground glass opacity, interlobular septal thickening, bilateral diffuse infiltrates and pleurisy/pleural effusion (55.6%, 50%, 50%, and 44.4%, respectively). The variables independently associated with pulmonary involvement were anti- ribonucleoprotein (RNP) antibody (OR:7.9; 95% CI: 1.1–54.6) and anti-neutrophil cytoplasmic antibodies (ANCA, OR: 73.6; 95% CI: 2.9-1894.7).Conclusions Lung involvement was frequent in SLE patients from Southeast China. Anti-RNP antibody and ANCA were significantly associated with abnormal HRCT findings.

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“…The prevalence of women is significantly higher than that of men . The pathogenesis of SLE remains unclear, but environmental triggers and genetic factors have been reported to contribute to the destruction of immune tolerance systems and the production of immunological lymphocytes, antibodies, and inflammatory cytokines, damaging tissues and organs . Components of lymphocytes, antibodies, inflammatory cytokines, and complements in peripheral circulation vary among different active stages of SLE .…”

Section: Introductionmentioning

confidence: 99%