Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis?

Abstract

Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy. We report a case of a 67-year-old woman with an inflammatory ulcerated plaque in the left masseter region. A skin biopsy showed dense perivascular infiltrate of mature plasma cells in the dermis without atypia and immunoglobulin light chain restriction. After physical examination and further investigation, we ruled out systemic disease. Our patient was successfully treated only with hydrocortisone cream application. Few cases of isolated benign primary cutaneous plasmacytosis have been described, particularly in children. After excluding the diagnosis of a reactive process to an infection, which is unlikely in this case, we suspected of a rare manifestation of primary cutaneous plasmacytosis in adults with distinct presentation and clinical course.

Ulcerative cutaneous plasmacytosis

“…Here we describe a patient that presented with ulcerations in lieu of the papulonodules and plaques characteristic of cutaneous plasmacytosis. A report by António et al 4 identified a patient who similarly presented with ulceration as the sole manifestation of cutaneous plasmacytosis. As with our patient, there were no systemic symptoms of disease, and the ulceration responded to treatment with subsequent healing.…”

“…At this time, we have identified only 3 cases of cutaneous plasmacytosis in which ulceration was reported (Table I). 4, 5, 6 Additional patients are needed to further investigate this hypothesis.…”

Research on facial expression recognition of video stream based on OpenCV

“…where n k represents the specific pixel number of a certain grey level in the image; n represents the total pixel number of the image; L represents the gradation level of the gray level value of the image (António et al, 2017).…”