Do you know this syndrome? Werner syndrome

Bilgiç, Özlem

doi:10.1590/abd1806-4841.20174640

Cited by 6 publications

(4 citation statements)

References 6 publications

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“…Early graying can be observed in prema-ture aging syndromes, e.g., Hutchinson progeria and Werner syndrome, where aging process is intensified. Premature graying can also be experienced by people suffering from pernicious anemia, autoimmune thyroid disease or Down syndrome [50][51][52] .…”

Section: Discussionmentioning

confidence: 99%

The (A)Symmetry of the Male Graying Beard Hairs as an Indication of the Programmed Aging Process

Poljšak

Dahmane

Adamič³

et al. 2020

ACC

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Aging interventions will be ineffective if we do not understand the basic principles of aging. Currently, there is no consensus on the issue whether aging is programmed or not. The hypothesis presented in this article indicates that aging (at least graying of male hairs) is programmed. This hypothesis is supported by the symmetry of the graying of male beard hairs. According to stochastic theories of aging, aging is a passive non-programmed process where random dispersion of graying hairs should result. On the contrary, programmed theories of aging would predict that there should be symmetry on the left and right parts of the face showing the same proportion, pattern and time of appearance of graying hairs.

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Section: Discussionmentioning

confidence: 99%

The (A)Symmetry of the Male Graying Beard Hairs as an Indication of the Programmed Aging Process

Poljšak

Dahmane

Adamič³

et al. 2020

ACC

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“…Werner syndrome is a very rare autosomal recessive disorder caused by the WRN gene, which encodes a RecQ DNA helicase. Patients with Werner syndrome have several major complications, including juvenile bilateral cataracts, diabetes, dyslipidemia, atherosclerosis, malignancy and refractory leg ulcers . Among them, the incidence of severe leg ulcers markedly reduces patient activity and quality of life.…”

Section: Introductionmentioning

confidence: 99%

“…Patients with Werner syndrome have several major complications, including juvenile bilateral cataracts, diabetes, dyslipidemia, atherosclerosis, malignancy and refractory leg ulcers. [3][4][5][6] Among them, the incidence of severe leg ulcers markedly reduces patient activity and quality of life. Severe leg ulcers are usually associated with diabetes or ischemia; however, Werner syndrome is also characterized by delayed wound healing, which involves thin connective tissues, physiological overpressure by bone transformation and delayed skin fibroblast cell growth.…”

Section: Introductionmentioning

confidence: 99%

Investigator‐initiated clinical study of a functional peptide, SR‐0379, for limb ulcers of patients with Werner syndrome as a pilot study

Nakagami

Sugimoto

Ishikawa

et al. 2019

Geriatrics Gerontology Int

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Aim An investigator‐initiated clinical study was carried out to evaluate the therapeutic potency of SR‐0379 for the treatment of leg ulcers in patients with Werner syndrome. Methods A multicenter, open‐label study was carried out from September 2017 to February 2018. The inclusion criteria for leg ulcers were: (i) leg ulcers in patients with Werner syndrome, diabetes or critical limb ischemia/venous stasis; and (ii) a wound size of >1 cm and <6 cm in diameter. Four individuals with Werner syndrome and diabetic ulcers, respectively, were enrolled. SR‐0379 (0.1%) was sprayed on skin ulcers once per day for 4 weeks. Efficacy was evaluated by determining the rate of wound size reduction as a primary end‐point at 4 weeks after the first treatment compared with the pretreatment wound size. As secondary end‐points, the DESIGN‐R score index, the 50% wound size reduction ratio, time to wound closure and quantification of wound bacteria were also evaluated. The safety of SR‐0379 was evaluated during the study period. Results The reduction rate of ulcer size treated with 0.1% SR‐0379 was 22.90% (mean) in the Werner syndrome ulcers group (n = 4) and 35.70% (mean) in the diabetic ulcers group (n = 4), respectively. The DESIGN‐R score decreased by 4.0 points in the Werner syndrome ulcers group and 4.3 points in the diabetic ulcers group. Two mild adverse events were reported in two patients, and causal relationships were denied in any events. Conclusion Treatment with SR‐0379 was safe, well‐tolerated, and effective for leg ulcers of both Werner syndrome and diabetes patients. Geriatr Gerontol Int 2019; 19: 1118–1123.

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“…Due to an increase in its incidence more people are giving medical attention to its psychological effects [7]. Studies regarding loss of hair pigmentation and associated factors have been done in other Asian countries like Turkey and India [8,9]. The lack of studies conducted in our area of the world, however, prompted us to perform a cross-sectional study among medical students to determine the frequency of premature greying of hair (PGH), how PGH affects psychological health, socio-cultural adjustment and issues rooting from low self-esteem in medical students.…”

Section: Introductionmentioning

confidence: 99%

Impact of Premature Greying of Hair on Socio-cultural Adjustment and Self-esteem among Medical Undergraduates in Foundation University, Islamabad

Saad

Babar

Majeed

et al. 2019

Cureus

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Introduction Greying of hair is an inevitable phenomenon that occurs commonly as a person ages. It usually occurs in the fourth decade regardless of gender but now a days, even people in their early twenties can experience premature greying. The objective of our study was to determine the frequency of premature greying of hair and its impact on the socio-cultural spheres of life and self-esteem of medical students. Methodology It is a descriptive cross-sectional study conducted at Foundation University Medical College (FUMC) from January to February 2017. All medical students of FUMC who gave their consent were included in the study sample. Students who were absent or unwilling to participate were excluded. Data was collected through a self-administered questionnaire, which was then analysed using SPSS version 17 (SPSS Inc., Chicago, IL). Results Out of 673 students, 210 (31.2%) suffered from premature greying of hair. The prevalence was higher among females (155/73.8%) as compared to males (55/26.2%). There was a statistical difference in perception of both the genders, regarding those with premature greying of hair trying to hide it (p-value = 0.000), premature greying of hair as contagious (p-value = .009) and the affected looking older than their actual age (p-value = 0.036). Conclusion The study showed that premature greying affected the socio-cultural spheres of students’ lives. Females were more prone to developing premature greying of hair. Genetics also play a significant role in the phenomenon. No positive correlation was found by using Rosenberg Self-esteem scale.

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Do you know this syndrome? Werner syndrome

Cited by 6 publications

References 6 publications

The (A)Symmetry of the Male Graying Beard Hairs as an Indication of the Programmed Aging Process

The (A)Symmetry of the Male Graying Beard Hairs as an Indication of the Programmed Aging Process

Investigator‐initiated clinical study of a functional peptide, SR‐0379, for limb ulcers of patients with Werner syndrome as a pilot study

Impact of Premature Greying of Hair on Socio-cultural Adjustment and Self-esteem among Medical Undergraduates in Foundation University, Islamabad

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