Correlation between the histopathology of chronic urticaria and its clinical picture

Rz, Marques; Criado, Roberta F. J.; Filho, Machado Cd; Jm, Tamanini; Mello, Claudio V.; Speyer, C

doi:10.1590/abd1806-4841.20165066

Cited by 15 publications

(14 citation statements)

References 10 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eosinophils were observed in the majority of CSU cases, particularly in those with bruising, which is in agreement with several studies that have shown an association between eosinophilic inflammatory infiltrates and more exuberant clinical pictures of CSU 11,19‐21 …”

Section: Discussionsupporting

confidence: 91%

“…Our study included 45 patients with a clinical diagnosis of CSU resistant to high doses of H1‐antihistamines with a higher percentage of females, in accordance with the demographic profile of the disease, 11,12 and many cases with a long duration of urticaria, as our department is a UCARE referral center for CU. Several patients exhibited occasional lesions that lasted longer than 24 hours and progressed to a violaceous hue (bruising) before complete fading, but none of these patients had systemic symptoms, low complement levels, or prominent vasculitis on histopathology.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

et al. 2021

View full text Add to dashboard Cite

Background Chronic spontaneous urticaria (CSU) may occasionally exhibit long‐lasting lesions with bruising, usually considered a hallmark of urticarial vasculitis (UV). Histopathology of these chronic urticarial lesions has not been extensively studied. Methods Skin biopsies from patients with anti‐H1 resistant CSU were evaluated for several parameters (edema, location, intensity, and cell composition of the inflammatory infiltrate, and abnormalities in the blood vessels). Results We studied 45 patients (37 female/8 male, mean age 49.3 years) with CSU, 60% of whom with occasional bruising lesions and 3 patients with hypocomplementemic UV. Histopathology in CSU showed mainly perivascular and interstitial inflammatory infiltrate (91.1%), including eosinophils (80%), neutrophils (77.8%), and lymphocytes (71.1%), vasodilatation (88.9%), intravascular neutrophils (95.6%), dermal edema (51.1%), swelling of endothelial cells (51.1%), and minor and rare fibrinoid necrosis and karyorrhexis (6.7%). Significant karyorrhexis and frank fibrinoid necrosis were observed, respectively, in two and three cases of UV. In patients with occasional bruising, mast cells occurred in fewer cases whereas eosinophils were more frequent, but no statistically significant difference was found for other parameters. Conclusions Histopathological findings were not significantly different between CSU with or without bruising lesions. Bruising may be associated with more severe forms of CSU with no histopathological signature, although UV cannot be completely excluded based on histopathology.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

et al. 2021

View full text Add to dashboard Cite

show abstract

“…14 In a study conducted by our group in 2016, we demonstrated that urticaria with predominance of eosinophils was related to greater clinical activity of the disease. 15 Other authors have described the presence of CD4 + T lymphocytes, variable number of monocytes, basophils, and lymphocytes. 2,16 The cytokines involved in the inflammatory skin process in urticaria reveal a mixed cytokine pattern with an increase in IL-4, IL-5, and IFN gamma.…”

Section: Discussionmentioning

confidence: 98%

Importance of type M1 and M2 macrophage expression in patients with chronic spontaneous urticaria

Criado¹,

Machado²,

Criado³

et al. 2020

Preprint

View full text Add to dashboard Cite

Mast cells and basophils interact with various cells in the urticaria lesion microenvironment, such as macrophages,.which form an essential component of innate immunity, and are involved in numerous functions including protein secretion. Objective: The aim of the present study was to characterize the macrophage phenotype in urticarial lesions of patients with chronic spontaneous urticaria (CSU) nonresponsive to antihistamines at optimized doses. And compare the phenotype with clinical and laboratory parameters such as age, gender, urticaria time, C-reactive protein (CRP), and total serum IgE, and autologous serum skin test (ASST). Methods: Twenty-eight patients with CSU refractory to antihistamines were included in the study. Epidemiological data, C-reactive protein, D-dimers, basophils in peripheral blood, and total serum IgE and ASST were assessed. The mannose receptor (CD206), CD163, CMAF, and pSTAT 1 were used to characterize the M1/M2 macrophage subpopulations. The immunolabeled cells per square millimeter were manually enumerated at a 400× magnification in 12 optical fields via light microscopy. Results: A predominance of M2 macrophages was seen in CSU patients. Statistical differences were observed between the CD206 marker and the disease course. No correlation was found between biomarkers and macrophage populations. Expression of CMAF was significantly higher in the patient sample compared to that in the control skin (patients without history of urticaria; p-value < 0.001). Conclusion: M2 macrophages were seen with significantly higher CMAF expression, which indicates macrophage activation in patients with CSU. CD206 expression was inversely correlated with disease time. Recently, two phenotypic macrophage variants, called M1 and M2, have been characterized in several studies, which express the killer and repair functions dependent on the stimulus and environment to which these

show abstract

“…Eosinophils also participate in chronic urticaria, primarily in patients lacking an autoimmune component, and accumulate in urticarial lesions where MBP and ECP can also be detected . Marques et al recently conducted a study where they found that tissue eosinophilia was linked to disease severity in patients with chronic urticaria.…”

Section: Mast Cells and Eosinophils In Allergic Diseasementioning

confidence: 99%

Human eosinophils and mast cells: Birds of a feather flock together

Robida

Puzzovio

Pahima

et al. 2018

Immunological Reviews

View full text Add to dashboard Cite

While the origin of the phrase "birds of a feather flock together" is unclear, it has been in use for centuries and is typically employed to describe the phenomenon that people with similar tastes or interests tend to seek each other out and congregate together. In this review, we have co-opted this phrase to compare innate immune cells of related origin, the eosinophil and mast cell, because they very often accumulate together in tissue sites under both homeostatic and inflammatory conditions. To highlight overlapping yet distinct features, their hematopoietic development, cell surface phenotype, mediator release profiles and roles in diseases have been compared and contrasted. What emerges is a sense that these two cell types often interact with each other and their tissue environment to provide synergistic contributions to a variety of normal and pathologic immune responses.

show abstract

Correlation between the histopathology of chronic urticaria and its clinical picture

Cited by 15 publications

References 10 publications

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

Histopathology of chronic spontaneous urticaria with occasional bruising lesions is not significantly different from urticaria with typical wheals

Importance of type M1 and M2 macrophage expression in patients with chronic spontaneous urticaria

Human eosinophils and mast cells: Birds of a feather flock together

Contact Info

Product

Resources

About