Nailfold capillaroscopy in leprosy

Lima, Adma Silva de; Pizzol, Vanessa Irusta Dal; Fritsch, Scheila; Fonseca, Gabriela Poglia; Mulinari‐Brenner, Fabiane; Müller, Carolina de Souza; Ottoboni, Vanessa Cristhine Dalombo

doi:10.1590/abd1806-4841.20164814

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…In this research, 60% of patients had some NVC abnormalities, such as micro-hemorrhages, dilated, bushy and corkscrew capillaries, although these changes were not specific for the disease manifestations. However, a large number of evidences marked the role of the interaction of Hansen's bacilli with endothelium in pathogenesis of the disease (45).…”

Section: Nailfold Capillaroscopy In Dermatolo-gy : Rosacea Alopecia Aerata and Leprosymentioning

confidence: 99%

Nailfold capillaroscopy : a comprehensive review on common findings and clinical usefulness in non-rheumatic disease

et al. 2021

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Nailfold video-capillaroscopy (NVC) is a useful diagnostic tool, used to early detect abnormalities in micro-circulation, providing a qualitative description of microvascular anomalies in Raynaud's phenomenon. NVC role in the diagnosis of Systemic Sclerosis is well known. In other rheumatic conditions such as connective tissue diseases, vasculitis, and arthritis, the NVC anomalies are often included in a scleroderma like pattern. The use of NVC in non-rheumatic diseases (NRD), with remarkable microvascular damage, as diabetes, is not standardized yet, although several research studies are carrying on. The aim of this article is to provide a resume of published results in order to lay the groundwork for the employment of NVC both in the diagnosis and follow up of microvascular complication in NRD. Furthermore, we mention NVC findings in pathologies without well recognize microvascular damages in their pathogenesis : micro-vessels abnormalities may suggest a different point of view.

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Section: Nailfold Capillaroscopy In Dermatolo-gy : Rosacea Alopecia Aerata and Leprosymentioning

confidence: 99%

Nailfold capillaroscopy : a comprehensive review on common findings and clinical usefulness in non-rheumatic disease

et al. 2021

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Nail fold capillaroscopy in leprosy: Unveiling the microvascular changes

Aggarwal,

Gandhi,

Singal

et al. 2024

Microvascular Research

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Onychoscopy and nailfold capillaroscopy in leprosy: A case–control study

Chanana,

Palanisamy,

Goyal

et al. 2024

CSDM

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Objectives: Studies have reported significant number of individuals with leprosy develop nail changes of heterogeneous variety. Direct or indirect damage secondary to neural damage, repeated trauma, vascular injury, anemia or following drug therapy have been implicated. In this study, we compared nail changes in cases of leprosy with controls to determine leprosy specific nail changes through detailed onychoscopic evaluation along with nailfold capillaroscopy. Materials and Methods: We performed a case–control study in a tertiary care institute with 30 leprosy patients and 30 age- and sex-matched controls. The study was done over a period of three months from June 2023 to August 2023. Patients were classified as per Ridley-Jopling classification. A detailed clinical examination followed by onychoscopy and proximal nailfold (PNF) capillaroscopy using Dermlite DL4 was done in all the nails of cases and controls. Results: A total of 600 nails of 30 leprosy patients on treatment attending our outpatient department were studied over a span of three months. Nail changes were seen in 26 (86.6%) out of 30 patients of leprosy disease compared to 10 (33.3%) of the controls. The most common nail finding seen in leprosy patients was longitudinal melanonychia followed by leukonychia. Transverse lines, leukonychia, subungual hyperkeratosis, nail discoloration, nail pallor, onychochauxis, subungual hematoma, splinter hemorrhage, and brachyonychia were seen more in cases than in controls, and the difference was statistically significant. The PNF capillaroscopy showed microhemorrhages in eight patients of leprosy while none in controls. Conclusion: Nail changes seen in leprosy are multifactorial. The PNF capillaroscopy showed microhemorrhages, which could be an early feature of vascular changes in leprosy.

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Nailfold capillaroscopy in leprosy

Cited by 3 publications

References 7 publications

Nailfold capillaroscopy : a comprehensive review on common findings and clinical usefulness in non-rheumatic disease

Nailfold capillaroscopy : a comprehensive review on common findings and clinical usefulness in non-rheumatic disease

Nail fold capillaroscopy in leprosy: Unveiling the microvascular changes

Onychoscopy and nailfold capillaroscopy in leprosy: A case–control study

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