Brazilian guidelines for diagnosis, treatment and follow-up of primary cutaneous melanoma - Part II

Castro, Luiz Guilherme Martins; Bakos, Renato Marchiori; Neto, João Pedreira Duprat; Bittencourt, Flávia Vasques; Giacomo, Thais Helena Bello Di; Serpa, Sergio Schrader; Messina, Maria; Loureiro, Walter Refkalefsky; Macarenco, Ricardo; Stolf, Hamílton Ometto; Gontijo, G.

doi:10.1590/abd1806-4841.20164715

Cited by 13 publications

(11 citation statements)

References 99 publications

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“…Twenty-one records were included in the full-text review after title and abstract screening and removal of duplicates. Of these guidelines, four were dismissed, as they had already expired at the time of our search [9][10][11][12], one was in development [13] and another one was only available as a presentation [14]. Furthermore, we identified four more duplicates [15][16][17][18] and two records were excluded due to unclear methodological approaches [19,20].…”

Section: Guideline Identificationmentioning

confidence: 99%

The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments

Steeb

Wessely

Drexler

et al. 2020

Cancers

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Multiple guidelines on cutaneous melanoma (CM) are available from several consortia and countries. To provide up-to-date guidance in the rapidly changing field of melanoma treatment, guideline developers have to provide regular updates without compromises of quality. We performed a systematic search in guideline databases, Medline and Embase to identify guidelines on CM. The methodological quality of the identified guidelines was independently assessed by five reviewers using the instruments “Appraisal of Guidelines for Research and Evaluation” (AGREE II) and “Recommendation EXcellence” (AGREE-REX). We performed descriptive analysis, explored subgroup differences using the Kruskal–Wallis (H) test and examined the relationship between distinct domains and items of the instruments with Spearman’s correlation. Six guidelines by consortia from Australia, France, Germany, Scotland, Spain and the United States of America were included. The German guideline fulfilled 71%–98% of criteria in AGREE II and 78%–96% for AGREE-REX, obtaining the highest scores. Deficiencies in the domains of “applicability” and “values and preferences” were observed in all guidelines. The German and Spanish guidelines significantly differed from each other in most of the domains. The domains “applicability” and “values and preferences” were identified as methodological weaknesses requiring careful revision and improvement in the future.

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Section: Guideline Identificationmentioning

confidence: 99%

The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments

Steeb

Wessely

Drexler

et al. 2020

Cancers

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“…A presença de mitose e regressão seria decisiva para indicar BLNS em algum momento e hoje não o é mais. 25 No presente estudo, diferentes motivos justificaram o BLNS para pacientes com Breslow <0,8 mm: regressão foi identificada em 5 casos, 1 lesão acral, 1 lesão com satelitose, 2 de taxa mitótica >1, uma biópsia por raspagem incompleta, onde a espessura de Breslow foi determinada como "pelo menos", 2 casos em que o paciente exigiu a cirurgia por vontade própria.…”

Section: Discussionunclassified

“…29 As taxas de complicações de MC relatadas após a BLNS são altamente variáveis na literatura, ficando entre 1,8% e 29,9%. [30][31][32] Em uma revisão sistemática da literatura, Moody et al 25 encontraram uma taxa geral de complicações de 11,3% entre os pacientes submetidos à BLNS, a maioria temporária. A incidência de infecção foi de 2,9%; seroma, 5,1%; hematoma, 0,5%; linfedema, 1,3%; e lesão do nervo, 0,3%.…”

Section: Cadeias De Drenagemunclassified

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Sentinel lymph node biopsy for cutaneous melanoma in a real life setting: analysis of 47 cases treated at a private clinic in Brazil

Almeida¹,

Saraiva²,

Messina³

et al. 2021

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“…Samples were obtained in the period between 1996 and 2010 and reviewed by an experienced melanoma pathologist (G.L.). Histopathological prognostic factors were established according to the WHO protocol and guidelines of the Brazilian Society of Pathology (Castro et al, , ; LeBoit, Burg, Weedon, & Sarasain, ). The study was approved by the ethics review board of the Federal University of Sao Paulo (CEP #1013/11), Brazil.…”

Section: Methodsmentioning

confidence: 99%

IMP dehydrogenase rod/ring structures in acral melanomas

Keppeke

Barcelos

Fernandes

et al. 2020

Pigment Cell Melanoma Res

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Acral lentiginous melanoma (ALM) is a rare subtype of melanoma with aggressive behavior. IMPDH enzyme, involved in de novo GTP biosynthesis, has been reported to assemble into large filamentary structures called rods/rings (RR) or cytoophidium (cellular snakes). RR assembly induces a hyperactive state in IMPDH, usually to supply a high demand for GTP nucleotides, such as in highly proliferative cells. We investigate whether aggressive melanoma tumor cells present IMPDH‐based RR structures. Forty‐five ALM paraffin‐embedded tissue samples and 59 melanocytic nevi were probed with anti‐IMPDH2 antibody. Both the rod‐ and ring‐shaped RR could be observed, with higher frequency in ALM. ROC curve analyzing the proportions of RR‐positive cells in ALM versus nevi yielded a 0.88 AUC. Using the cutoff of 5.5% RR‐positive cells, there was a sensitivity of 80% and specificity of 85% for ALM diagnosis. In ALM, 36 (80%) showed RR frequency above the cutoff, being classified as RR‐positive, compared with only 9 (15%) of the nevi (p < .001). Histopathology showed that 71% of the RR‐positive specimens presented Breslow thickness > 4.0mm, compared with only 29% in the RR‐low/negative (p = .039). We propose that screening for RR structures in biopsy specimens may be a valuable tool helping differentiate ALM from nevi and accessing tumor malignancy.

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Brazilian guidelines for diagnosis, treatment and follow-up of primary cutaneous melanoma - Part II

Cited by 13 publications

References 99 publications

The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments

The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments

Sentinel lymph node biopsy for cutaneous melanoma in a real life setting: analysis of 47 cases treated at a private clinic in Brazil

IMP dehydrogenase rod/ring structures in acral melanomas

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