Plasmoacanthoma

Braga, Bruna Backsmann; Michalany, Alexandre Ozores; Filho, Jayme de Oliveira; Cucé, Luiz Carlos

doi:10.1590/abd1806-4841.20164673

Cited by 3 publications

(14 citation statements)

References 9 publications

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“…Habitual tobacco or gum chewing and use of flavored dentifrices or dentures have been speculated to be associated with local plasma cell proliferation, 4,6 supporting this hypothesis. Indeed, trauma and insect bite have been implicated in the pathogenesis of PA 2–6 …”

Section: Discussionmentioning

confidence: 90%

“…The literature review elucidated that PA mostly arose in perioral skin or oral mucosa, particularly along the angles of the elderly, suggesting that the accumulation of mechanical or chemical stress may contribute to the pathogenesis of PA 2,3 . Habitual tobacco or gum chewing and use of flavored dentifrices or dentures have been speculated to be associated with local plasma cell proliferation, 4,6 supporting this hypothesis. Indeed, trauma and insect bite have been implicated in the pathogenesis of PA 2–6 …”

Section: Discussionmentioning

confidence: 94%

“…Previous studies hypothesized that preceding allergic or chronic inflammation could elicit reactive proliferation of plasma cells via B‐cell growth and differentiation 4,6,8 . Thus, inflammation‐driven deviation to plasma cells can be further enhanced, particularly in intrinsically plasma cell‐rich orifice tissue represented by the lips and gingiva, 9 setting the initial basis for PA. Cheilitis and Candida infection were noted as preceding conditions in previously reported PA cases 2,3 …”

Section: Discussionmentioning

confidence: 99%

“…Psoriasiform epidermal change represents a hallmark histopathological finding of PA; 4 however, the underlying mechanism has been ill‐dissected. Considering lymphocytic infiltration mainly consisted of CD4 lymphocytes and dermal edema, cytokines released from those infiltrating cells may account for this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…This, along with its rarity, makes the diagnosis of PA quite challenging, particularly when PA is formed at unusual anatomical locations. Because of the limitation in accumulated cases in the literature, a therapeutic approach for PA has not been standardized 2–6 …”

Section: Introductionmentioning

confidence: 99%

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Long‐term remission of unusual plasmoacanthoma on the nasal canthus achieved by intralesional corticosteroid injection: Insights into the pathogenesis and treatment planning based on a literature review

Ito‐Muramatsu

Fukuyama

Hayakawa

et al. 2021

The Journal of Dermatology

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Plasmoacanthoma (PA) is a verrucous tumor predominantly developing on periorificial areas, which has been considered as an unusual subtype of plasmacytosis circumorificialis. Because of its rarity and clinical resemblance to several verrucous dermatological disorders, accurate diagnosis of PA is quite challenging. Herein, we present an extremely unusual case of PA which arose on both sides of the nasal canthus and was successfully treated with intralesional corticosteroid injections. To elucidate clinicopathological features of this condition, a literature review was also attempted. A 78‐year‐old woman visited us with a 2‐year history of eruptions affecting both sides of the nasal canthus. At a local clinic, the diagnosis and treatment had been unsuccessful due to non‐specific histological findings, leading to the referral to our institute. On physical examination, verrucous and lobulated reddish plaques were observed. In histology, psoriasiform epidermal change and dense plasma cell infiltration in the dermis were detected. The diagnosis of PA was made. After 5‐monthly intralesional triamcinolone acetonide injections, the lesions became hardly noticeable with no evidence of recurrence. A literature review found five PA cases. PA predominantly arose on the periorificial area, mostly in or around the mouth, except one case which developed on the extra‐oral or perioral area. Intralesional corticosteroid injection has been preferably performed, which frequently achieved successful remission. Chronic inflammation has been reported as a preceding condition. Abundance of plasma cells in the lacrimal glands and conjunctiva, together with pre‐existing allergic conjunctivitis and habitual scratching, might have contributed to PA development in our case. Histopathological detection of psoriasiform epidermal change and dense dermal plasma cell infiltration is indispensable for the diagnosis of PA. For accurate diagnosis, optimization of treatment, and further accumulation of extra‐oral/perioral PA cases, a skin biopsy needs to be proactively performed on verrucous lesions on relatively unfamiliar orifice sites.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Long‐term remission of unusual plasmoacanthoma on the nasal canthus achieved by intralesional corticosteroid injection: Insights into the pathogenesis and treatment planning based on a literature review

Ito‐Muramatsu

Fukuyama

Hayakawa

et al. 2021

The Journal of Dermatology

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Plasmoacanthoma of Lip—A Rare Case with Review of Literature

Vijendra Shenoy,

Kabekkodu,

Kshithi

et al. 2024

Indian J Otolaryngol Head Neck Surg

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Perianal Plasmoacanthoma After BCG-Immunotherapy: Case Report and Review of Literature

Roohaninasab¹,

Goodarzi²,

Chalangari³

et al. 2022

ACTA

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Plasmoacanthoma is a rare verrucous tumor classified as a form of reactive plasmacytosis. We present the first reported case of plasmoacanthoma following exposure to bacillus Calmette-Guérin (BCG) and a comprehensive review of the literature to better illustrate the patients’ characteristics and proposed risk factors, clinical features, diagnosis, treatment, and outcome of current reports. A 64-year-old female presented with a perianal hyperkeratotic plaque and diffused inflammatory macerated erosions in the intergluteal cleft and adjacent to the plaque after intravesical BCG immunotherapy. Laboratory studies disclosed systemic abnormalities and local infection or malignancies. Biopsy showed intradermal polyclonal plasma cell infiltration with acanthosis. The lesions were successfully treated with carbon dioxide laser ablation followed by the combination of pulsed dye laser and intralesional corticosteroid. Diagnosis of cutaneous reactive plasmacytosis should be confirmed by excluding the systemic causes of plasmacytosis and malignancies. It responds well to intralesional corticosteroids; however, in severe cases and large sizes, other treatments such as carbon dioxide laser ablation and pulsed dye laser should be considered as a combined therapy. Identification of causative factors is impractical while skin irritants with subsequent inflammation seem to be involved; as in the current report, BCG contact with skin initialized the pathologic process.

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Plasmoacanthoma

Cited by 3 publications

References 9 publications

Long‐term remission of unusual plasmoacanthoma on the nasal canthus achieved by intralesional corticosteroid injection: Insights into the pathogenesis and treatment planning based on a literature review

Long‐term remission of unusual plasmoacanthoma on the nasal canthus achieved by intralesional corticosteroid injection: Insights into the pathogenesis and treatment planning based on a literature review

Plasmoacanthoma of Lip—A Rare Case with Review of Literature

Perianal Plasmoacanthoma After BCG-Immunotherapy: Case Report and Review of Literature

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