Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis

Abstract

Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. The aim of this work is to emphasize the need to include this differential diagnosis in cases of epidermal detachment and to review the literature on the subject and this specific clinical presentation.

Linear IgA dermatosis in association with angioimmunoblastic T‐cell lymphoma infiltrating the skin: A case report with literature review

“…The major differential diagnosis in this case was TEN. LABD presenting as TEN has already been published . All reported cases except one could be linked to drug intake.…”

Vancomycin‐induced linear IgA bullous dermatosis (LABD)—an atypical presentation

“…In adults, it is commonly induced by drugs and the main drug related to LABD is vancomycin . Vancomycin‐induced LABD is associated with a severe presentation of the disease that may mimic toxic epidermal necrolysis (TEN) . There have also been numerous reports of LABD mimicking erythema multiforme and TEN but not many reports of this disease with mucosal presentation similar to a herpetic infection and evolving to a bullous pemphigoid‐like clinic presentation.…”

Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature

“…The disease occurred probably because of 2 factors: drug and infection together. The majority of patients with reported druginduced LABD also had other diseases, such as neoplasia (1,7,(30)(31)(32)(33)(34), diabetes (1,30,(35)(36)(37)(38), heart and lung diseases (1,36,(39)(40)(41)(42), rheumatoid arthritis (43)(44)(45) or ulcerative colitis (18,19). Concomitant diseases may also be implicated in triggering the onset of suspected druginduced LABD (30).…”