Nevus lipomatosus cutaneous superficialis

Abstract

We report a case of nevus lipomatosus cutaneous superficialis of Hoffman-Zurhelle (NCLS), with multiple lesions, in a ten-year-old child. The NLCS is considered rare. The classical clinical presentation is characterized by multiple skin-colored or yellowish papules and nodules, which can have a linear distribution. Histologically, it is characterized by the presence of mature ectopic adipocytes in the dermis. The main therapeutic option is surgical excision. The classical Nevus lipomatosus cutaneous superficialis is reported in this case.

Nevus Lipomatosus Cutaneous Superficialis Mimicking an Acrochordon

“…The pathogenesis of NLCS is still unclear. Hoffman and Zurhelle postulated that the deposition of adipocytes in the dermis is secondary to degenerative alterations in connective tissue [ 2 ]. Other theories suggest ectopic adipocyte origination from the pericytes of dermal vessels, adipose metaplasia in the connective tissue within the dermis, or developmental displacement of adipose tissue [ 1 - 4 ].…”

“…Nevus lipomatosus cutaneous superficialis (NLCS) is a rare cutaneous hamartoma characterized by mature adipocytes in the papillary or reticular dermis [ 1 , 2 ]. Clinically, there are two forms of NLCS.…”

“…Clinically, there are two forms of NLCS. The classical form is more common and consists of multiple soft, elastic, skin-colored, cerebriform, and pedunculated papules or nodules that can coalesce to form plaques with surfaces that may be wrinkled, smooth, or have a peau d’orange appearance [ 2 ]. The classical form usually appears in the pelvic and gluteal regions, but there have been several reported cases on the face [ 2 , 3 ].…”

“…The classical form is more common and consists of multiple soft, elastic, skin-colored, cerebriform, and pedunculated papules or nodules that can coalesce to form plaques with surfaces that may be wrinkled, smooth, or have a peau d’orange appearance [ 2 ]. The classical form usually appears in the pelvic and gluteal regions, but there have been several reported cases on the face [ 2 , 3 ]. The rarer solitary form is characterized as a sessile, dome-shaped nodule or papule that appears in variable locations, but has a predilection for the trunk [ 2 , 3 ].…”

“…The classical form usually appears in the pelvic and gluteal regions, but there have been several reported cases on the face [ 2 , 3 ]. The rarer solitary form is characterized as a sessile, dome-shaped nodule or papule that appears in variable locations, but has a predilection for the trunk [ 2 , 3 ]. This form of NLCS most often appears after the second decade of life [ 3 ].…”