Mycosis fungoides and Kaposi’s sarcoma association in an HIV-negative patient

An 88-year-old Inuit man from Northern Canada presented with an extensive skin rash associated with numerous violaceous skin nodules on his palms and lower extremities. Biopsy of a skin nodule revealed Kaposi’s sarcoma (KS), a human herpesvirus 8 (HHV8)-associated malignancy, whereas biopsy of the erythematous skin showed an atypical infiltrate of CD4-positive T-cells that, together with TCR gene rearrangement and presence of clonal T-cells in peripheral blood by flow cytometry, was consistent with a T-cell lymphoma, mycosis fungoides (MF) subtype. Serology was negative for HIV and HTLV-I/II and no immunodeficiency syndrome was identified. The patient was successfully treated with an oral retinoid for KS, and with topical hydrocortisone and ultraviolet B (UVB) phototherapy for MF. This case highlights the existence of HHV8-related lesions in native persons of Northern Canada, and also that MF-induced immunosuppression combined with immunosenescence may play a role in the development of non-HIV-related KS.

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“…6 7 However, the coexistence of KS and MF in the same patient is a rarely described phenomenon. 8–10 …”

Section: Introductionmentioning

confidence: 99%

Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada

et al. 2021

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“…In recent literature, some cases of association between KS and thymoma have been reported, most of them with cytopenia secondary to the thymic neoplasm (either pure red cell aplasia, erythroblastopenia, CD4+ lymphopenia, or Good syndrome—combined B and T cell immunodeficiency). Some reported cases include KS in HIV-negative patients, some in unique presentation sites [ 4 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV-Negative Patient with Thymoma

Araújo

Baptista

Mascarenhas

et al. 2017

Case Reports in Otolaryngology

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Introduction Kaposi sarcoma is an angioproliferative disorder that requires infection with human herpesvirus 8 (HHV-8) for its development. The majority of cases are associated with HIV infection or other immunocompromising conditions. Thymomas are occasionally associated to cytopenia, which may alter the patients' immune responses. Methods Case report using clinical records. Results Case report of a 46-year-old male patient diagnosed with thymoma and myasthenia gravis. The patient was referred to an otolaryngology consultation with complaints of facial pain in the right malar region, interpreted as an acute sinusitis. Following examination, an expansive maxillary sinus mass was found, and endoscopic surgery was undertaken. After careful investigation, it was diagnosed as a Kaposi sarcoma. Conclusions It is thought to be the first described case of a maxillary sinus Kaposi sarcoma in an HIV-negative patient. Thus, this entity has to be considered in the differential diagnosis of sinus masses, even in non-HIV patients.

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Mycosis fungoides and Kaposi’s sarcoma association in an HIV-negative patient

Cited by 2 publications

References 8 publications

Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada

Concurrent development of HIV-negative Kaposi’s sarcoma and mycosis fungoides in an elderly Inuit from Canada

Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV-Negative Patient with Thymoma

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