Nodular tertiary syphilis in an immunocompetent patient

Abstract

Acquired syphilis can be divided into primary, secondary, latent, and tertiary stages. About 25% of patients with untreated primary syphilis will develop late signs that generally occur after three to five years, with involvement of several organs. The authors present an immunocompetent female who developed a tertiary stage syphilis presenting with long-standing nodular plaques.

Predicting asymptomatic neurosyphilis using peripheral blood indicators

“…There is no internationally approved PCR assay for Treponema pallidum . These, together with its asymptomatic or protean clinical manifestations which mimic other diseases, lead to the diagnosis tending to be overlooked [ 24 – 27 ]. In fact, although the suspect has undergone routine CSF examinations, clinicians are increasingly diagnosing and tracking suspicious patients; And since CSF assessment is not without its dangers, it is not recommended for the vast majority of asymptomatic patients by the latest guideline [ 17 ].…”

Concurrent benign tertiary syphilis and asymptomatic neurosyphilis in an immunocompetent patient

“…E. Cozzani, 1,2 G. Gasparini, 1,2,3 G. Ciccarese, 2,* F. Drago, 2 I. Trave, 1,2 V. Vellone, 4 C.M. Biatta, 4 F. Cabiddu, 5 G. Ribizzi, 6…”

“…Editor Syphilis is known to be 'the great imitator': since the patient's history is often deceiving and the spectrum of clinical signs and symptoms is extremely broad, diagnosis may be particularly challenging. 1,2 Tertiary syphilis is rarely seen nowadays but it should be taken into account when dealing with granulomatous disorders of unclear nature. [1][2][3][4] Indeed, up to 25% of the patients with untreated primary syphilis develop symptoms of tertiary syphilis, usually occurring 3-5 years after primary infection and involving several organs, mainly skin, heart and central nervous system.…”

“…1,2 Tertiary syphilis is rarely seen nowadays but it should be taken into account when dealing with granulomatous disorders of unclear nature. [1][2][3][4] Indeed, up to 25% of the patients with untreated primary syphilis develop symptoms of tertiary syphilis, usually occurring 3-5 years after primary infection and involving several organs, mainly skin, heart and central nervous system. 1 We recently observed an unsuspected case of syphilitic gummas in a patient whose history was definitively not evocative for sexually transmitted diseases (STDs).…”

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“…Das histologische Bild einer Syphilis kann sich, analog zum klinischen Bild, sehr unterschiedlich darstellen. Eine Manifestationsform ist die granulomatöse Form [4]. Die Menge der vorhandenen Plasmazellen in einer granulomatösen Syphilis kann stark variieren.…”