Collision of malignant neoplasms of the skin: basosquamous cell carcinoma associated with melanoma

Medeiros, Paula Mota; Alves, Natália Ribeiro de Magalhães; Silva, Cássia Camarinha da; Faria, Paula Carolina Pessanha de; Barcauí, Carlos Baptista; Piñeiro-Maceira, Juãn

doi:10.1590/abd1806-4841.20153845

Cited by 13 publications

(16 citation statements)

References 8 publications

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“…Based on tumor composition, Satter et al classified these tumors into collision, combined, colonized and biphenotypic tumors . Collision tumors are defined as two neoplasms composed of different cell origins that present in close proximity but maintain a well‐defined boundary . Combined tumors are defined as neoplasms composed of two phenotypically distinct yet intermingled cell populations, for which the use of immunohistochemical studies is usually required to highlight the two distinct cell populations .…”

Section: Discussionmentioning

confidence: 99%

Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature

et al. 2019

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We report two cases of combined cutaneous tumors composed of melanoma and carcinoma. The first tumor presented as a 5-mm pink-blue macule over the right zygomatic arch in an 85-year-old man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of melanoma (highlighted by SOX10 and MART-1, with high Ki-67 proliferative index) intermixed with nodular basal cell carcinoma (highlighted by pan-cytokeratin and Ber-EP4). The neoplastic melanocytes were confined to the basal cell carcinoma nodules, and a diagnosis of combined melanoma in situ and basal cell carcinoma was rendered. After therapeutic excision, the patient was disease-free at 9 months after the initial diagnosis. The second tumor presented as a 6-mm pink-brown crusted papule on the right forehead in an 89-yearold man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered. These two cases highlight the importance of recognizing these rare types of melanocytic-epithelial cutaneous neoplasms to arrive at an accurate diagnosis that may inform appropriate disease stage and therapy. K E Y W O R D Sbasal cell carcinoma, combined tumors, melanoma, squamous cell carcinoma

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Section: Discussionmentioning

confidence: 99%

Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature

et al. 2019

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“…In these cases, prognosis and treatment are dictated by the tumor of greater severity. 10 Dermatoscopy is an auxiliary tool in the diagnosis of pigmented lesions. In the case presented here, the blackened portion of the lesion showed criteria suspicious for melanoma.…”

Section: Discussionmentioning

confidence: 99%

Collision tumor: pigmented Bowen's disease and seborrheic keratosis

Fernandes

Martinez

Nobre

et al. 2018

An. Bras. Dermatol.

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Bowen's disease is a type of squamous cell carcinoma in situ of the skin. The pigmented form is rare and represents less than 2% of cases. We report a case of a 74-year-old black man with a blackened and asymptomatic leg injury for about 6 months. Clinically, and under dermatoscopy, the injury was suggestive of melanoma or melanoacanthoma, and a definitive diagnosis was made by histopathological examination.

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“…Similar dependence is seen with combined UV radiation and various gene variants of the Melanocortin-1 receptor (MC1R) [ 5 ], [ 6 ]. These common risk factors and mechanisms in the genesis of melanocytic and keratinocyte tumors suggest their possible simultaneous presentation in the same patient [ 1 ], [ 2 ], [ 3 ], [ 4 ], [ 5 ], [ 6 ], [ 7 ], [ 8 ], [ 9 ], [ 10 ], [ 11 ], [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…The simultaneous manifestation of melanocyte and keratinocyte skin tumours may be seen in the form of the so-called 1) collision tumours – when they are established within the same lesion (clinically, dermatoscopically and/or histologically) and 2) simultaneous occurrence of two or more histologically distinct primary malignancies [ 12 ], [ 13 ]. The presence of two different malignant tumours at the same time, located within the same histological sample, is referred to as the so-called collision tumours [ 14 ], [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, depending on the boundaries between cells, the simultaneous manifestation of two histologically distinct tumours is subdivided into two types: 1) collision type, in which each cellular type is distinct, and 2) intermingled type, in which the two cell types are “intimately related” [ 16 ]. The predominant number of documented cases in the world literature represents the BCC and MM combination [ 12 ], [ 14 ], [ 15 ], [ 16 ]. In this respect, their correlation is interesting, defined as parasitism, i.e.…”

Section: Discussionmentioning

confidence: 99%

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High-Risk BCC Of the Lower Eyelid in Patient with Presternal Located Cutaneous Melanoma and BCC Of the Shoulder: Melolabial Advancement Flap Combined with Undermining Surgical Approach As Promising Complex One Step Treatment Option!

Tchernev¹,

Lozev²,

Pidakev³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:It is assumed that the occurrence of keratinocyte and melanocytic tumours is multifactorial driven. Certain risk factors such as solar radiation, p53 protein and Melanocortin-1 receptor (MC1R) prove to be common to their development, which at the same time shows that their simultaneous manifestation in the same patients, for example, is quite possible. Such a manifestation could be observed as collision tumours within the same solitary lesion or as a simultaneous occurrence within two completely different lesions that are clearly distinguished from one another.CASE REPORT:An 85-year-old patient is presented with three primary cutaneous tumours located in region presternal, infraorbital sinistra and scapularis extra. The lesions were removed during a single surgical session. For the high-risk basal cell carcinoma (BCC) in the lower eyelid, the so-called melolabial advancement flap was applied, and for the tumours located in the other two areas, the undermining surgical approach was applied. The subsequent histological analysis found that the case referred to two keratinocyte tumours (BCC) and one melanocyte tumour (cutaneous melanoma).CONCLUSIONS:The patient presented is interesting with regard to 1) the simultaneous presentation of three primaries with different localization (so far not described in the world literature, namely 2 basal cell carcinomas and one melanoma in the same patient concurrently), 2) one of the basal cell tumours belongs to the group of high-risk (according to the localization) and meanwhile advanced BCC (according to the infiltration degree of the underlying tissue-infiltration of the musculature) and 3) their simultaneous successful surgical treatment in a single surgical session under local anaesthesia.

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Collision of malignant neoplasms of the skin: basosquamous cell carcinoma associated with melanoma

Cited by 13 publications

References 8 publications

Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature

Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature

Collision tumor: pigmented Bowen's disease and seborrheic keratosis

High-Risk BCC Of the Lower Eyelid in Patient with Presternal Located Cutaneous Melanoma and BCC Of the Shoulder: Melolabial Advancement Flap Combined with Undermining Surgical Approach As Promising Complex One Step Treatment Option!

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