Dermoscopic and Clinical Features of Pigmented Skin Lesions of the Genital Area

Cengiz, Fatma Pelin; Emiroğlu, Nazan; Wellenhof, Rainer Hofmann

doi:10.1590/abd1806-4841.20153294

Cited by 29 publications

(23 citation statements)

References 22 publications

(43 reference statements)

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“…The most frequent pattern are the parallel pattern and ring-like pattern followed by globular, reticular or mixed patterns. [6][7][8][9] We have found only a previously reported case of penile melanosis associated with lichen sclerosus. [10] 4.…”

Section: Discussionmentioning

confidence: 99%

Penile Melanotic Macules: A Case Report

Giménez-García¹,

Molina²

2018

ARC Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

Penile Melanotic Macules: A Case Report

Giménez-García¹,

Molina²

2018

ARC Journal of Dermatology

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“…This includes melanotic macules or lentigenosis, nevi, melanoma, angiokeratoma, seborrheic keratosis, squamous cell carcinoma, and basal cell carcinoma (BCC). [10]…”

Section: Normal Physiological Lesions Of the Genitaliamentioning

confidence: 99%

“…However, standard algorithms such as ABCDE-asymmetry, borders, color, diameter, evolution; might not be suitable for evaluating genital pigmented macules. [10] Various patterns have been described on dermatoscopy as follows:…”

Section: Normal Physiological Lesions Of the Genitaliamentioning

confidence: 99%

Dermatoscopy of nonvenereal genital dermatoses: A brief review

Kamat

Vinay

2019

Indian J Sex Transm Dis

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The scope of dermatoscopy has now vastly expanded and shows promising use for characterization of both pigmentary and inflammatory dermatoses affecting the skin, nail, and mucosae. Due to concerns of contamination and spread of infection, dermatoscopy has not been widely studied for genital mucosal dermatoses. In this article, we review the dermatoscopic features of nonvenereal dermatosis affecting the genitalia. Although biopsy is required for a definitive diagnosis, dermatoscopy is useful to identify atypical and suspicious pigmentary lesions. For the inflammatory dermatoses and other benign dermatoses, presence of few characteristic findings can aid in the diagnosis.

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“…Mucosal melanomas arise from mucosal epithelium anywhere but are most commonly found in three areas; the vulvova-gina (18% of cases), the anorectum (24% of cases) and the oral cavity, nasal cavity or sinuses (55% of cases) (5). Vulvar melanoma more frequently occurs in postmenopausal women, and long-term prognosis is poor due to the high rate of recurrence (6,7).…”

Section: Introductionmentioning

confidence: 99%

Recurrent Vulvar Melanoma – a Case Report

Jovičić¹,

Kesić

Dordević

et al. 2019

Serbian Journal of Dermatology and Venereology

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Melanoma rarely develops in the genital area. It is responsible for 5% of all vulvar malignancies. Postmenopausal women are usually more affected and the main differential diagnosis is vulvar melanosis and vulvar nevi. There are limited numbers of studies on dermoscopic features of mucosal melanoma, particularly early-stage lesions. Dermoscopic criteria have been described for the diagnosis of vulvar melanosis, and observational studies have been conducted to define the dermoscopic features of nevi and melanoma on the vulva. We are presenting the case of a 69-year old female with suspected recurrence of vulvar melanoma who previously had surgical removal of mucosal lentiginous melanoma on the left labia minor in June 2017. Five months after the primary melanoma surgery, the patient noticed de novo pigmentation at the left and right labia minor and urethral opening. On clinical examination, irregular light-brown pigmentation with ill-defined borders was evident on the labia minora of the vulva and around the external urethral orifice. On dermoscopy, irregular pigmented network, with white scar-like and structureless pinkish areas was evident. Incisional biopsy of the vulvar mucosa revealed melanoma in situ, confirming the local recurrence. CT scans of the head, thorax, abdomen and pelvis and gynaecological examination revealed no secondary deposits. Ultrasound of the regional inguinal lymph nodes revealed enlarged suspected pathologic involvement of the lymph nodes in both inguinal regions. Lymph node fine needle aspiration of lymph nodes in the left and right inguinal area revealed pleomorphic infiltrate of lymphoid cells with hemosiderin or melanoma pigment in the cytoplasm. Cystoscopic findings were within normal range. Interdisciplinary tumour board indicated wide excision of melanoma with margins of 1 cm and resection of the urethra, as well as biopsy of the enlarged left inguinal lymph node. Histopathological analysis of the resected mucosa revealed lentiginous spread of melanocytes showing moderate atypia, with focal pagetoid spread, without mitoses and ulceration and without invasion of lamina propria. The resection margins were tumour-free. Non-specific lymphadenitis was diagnosed on lymph node histopathological analysis. The patient was regularly monitored by a dermatologist and urologist, and had no recurrence. The accurate and prompt diagnosis is essential in the case of the vulvar melanoma which has unfavourable and unpredictable prognosis, with a tendency of local recurrences and regional and distant metastases in the case of invasive melanoma. In order not to miss early mucosal melanoma, dermatologists and gynaecologists should not avoid biopsy of lesions that demonstrate any clinical or dermoscopic feature of atypical melanocytic lesion, especially in case of the development of irregular pigmentation that expands and changes over time, the appearance of a solitary amelanotic papule or nodule requires excision or, in case of large diameter lesions, incision biopsies. Larger studies are needed to define more rigorously clinical and dermoscopic criteria that accurately distinguish early mucosal melanomas from benign skin lesions.

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Dermoscopic and Clinical Features of Pigmented Skin Lesions of the Genital Area

Cited by 29 publications

References 22 publications

Penile Melanotic Macules: A Case Report

Penile Melanotic Macules: A Case Report

Dermatoscopy of nonvenereal genital dermatoses: A brief review

Recurrent Vulvar Melanoma – a Case Report

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