Milker’s nodule - Case report

Adriano, André Ricardo; Quiroz, Carlos Daniel; Acosta, Martha Liliana; Jeunon, Thiago; Bonini, Flavia Kakiuti

doi:10.1590/abd1806-4841.20153283

Cited by 18 publications

(20 citation statements)

References 4 publications

(7 reference statements)

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“…After a five to fifteen-day period, one to four lesions appear, which will go through six evolution stages. 5 , 6 The lesions appear as erythematous macules, which become target-shaped with central ulceration and then exudative nodules. The fourth phase is the formation of dry regenerative lesions with dark spots on the surface.…”

Section: Discussionmentioning

confidence: 99%

“…These lesions became papillomatous lesions and, finally, fully receded, leaving a dry crust covering the previous lesion sites, with no scars. 6 - 8 The lesions are self-limited and usually disappear spontaneously within four to six weeks. However, in immunossuppressed patients, they may last for months and tend to recur.…”

Section: Discussionmentioning

confidence: 99%

“… 11 Other differential diagnoses include anthrax, atypical micobacteriosis, sporotrichosis, tularemia, loxoscelism, piogenic granuloma, and cowpox. 6 …”

Section: Discussionmentioning

confidence: 99%

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Milker's nodules: classic histological findings

Espósito

Jorge

Marques

et al. 2017

An. Bras. Dermatol.

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Milker's nodule is an occupational dermatovirose caused by Parapoxvirus, which is self-limited and, due to the lack of information of health professionals, may lead to underdiagnosis. We present two cases with exuberant manifestations and classic histopathologic findings. Case 1: Male, 19 years of age, milker, presented nodules and blisters on his palm for 15 days. Case 2: Male, 33 years of age, administrative assistant, presented erythematous nodules on his palms with lymphangitis for 5 days. He had milked a cow one week before the onset of the lesions. In both cases, the histopathology was representative and coincident with the clinical hypothesis. The lesions have presented complete involution. Milker's nodule diagnosis is based on clinical presentation, epidemiology, and histopathology. The knowledge of this disease is essential for its correct diagnosis, as well as to guide the implementation of public health measures and the appropriate treatment of sick cattle.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Milker's nodules: classic histological findings

Espósito

Jorge

Marques

et al. 2017

An. Bras. Dermatol.

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“…У фахових закордонних виданнях опубліковано низку статей про паравакцину [5,6], в одному з них наведено випадок цієї хвороби у 50-річного пацієнта після трансплантації гематопоетичних стовбурових клітин при множинній мієломі, яка перебігала з ускладненнями у вигляді багатоформної еритеми та загостренням реакції «трансплантації проти хазяїна» [7]. Власне діагноз парапоксвірусної інфекції за кордоном підтверджують також методом електронної мікроскопії [8].…”

Section: результати досліджень та їх обговоренняunclassified

Rare occupational infection: two cases of paravaccinia – viral disease of milkers at Bukovyna

Sokol¹,

Randiuk²,

Sydorchuk³

et al. 2018

ScienceRise: Medical Science

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48 1. Вступ Паравакцина (псевдокоров'яча віспа, вузлики доярок, pseudocowpox, milkers nodules)-вірусна хвороба, яка викликається pseudocowpox virus, представником родини Poxviridae, роду Parapoxvirus. На відміну від вірусів роду Orthopoxviridae, куди входять віруси натуральної віспи, віспи корів, вакцини та віспи мавп, які мають антигенну спорідненість і можуть викликати перехресний імунітет, вірус паравакцини такої спорідненості не має й на імунітет вище названих хвороб не впливає. За механізмом передачі паравакцина є представником контактних інфекцій, зооноз. Джерелом інфекції найчастіше є корови, (рідше-вівці), в яких

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“…Those infected share a history of contact with cattle, most notably from touching an infected cow's udder or nose. Infection has also been reported in those who handle raw beef . Transmission of the paravaccinia virus may take place through direct contact with contaminated items, or with live or dead cattle.…”

Section: Introductionmentioning

confidence: 99%

Milker's nodule: an occupational infection and threat to the immunocompromised

Handler

Рубинс

et al. 2018

Acad Dermatol Venereol

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Milker's nodule virus, also called paravaccinia virus, is a DNA virus of the parapoxvirus genus transmitted from infected cows to humans. It results from contact with cattle, cattle by-products or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers and agricultural tourists. The viral infection begins 5-15 days after inoculation as an erythematous-purple, round nodule with a clear depressed centre and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed. Milker's nodules are self-limited in immunocompetent individuals and heal without scarring within 8 weeks. Another member of the Parapoxvirus genus, the orf virus, is also transmitted from animals to humans by direct contact. While complications are rare, haematopoietic stem cell transplant recipients are at risk of graft-versus-host disease, as the parapoxvirus may trigger these complications in immunocompromised individuals. In addition, paravaccinia may serve as the antigen source for the development of erythema multiforme. The unique structure and replication process of viruses in the Poxvirus family, while includes the Parapoxvirus genus, have been a focus for treatment of infections and cancer. Manipulation of these viruses has demonstrated promising therapeutic possibilities as vectors for vaccines and oncologic therapy.

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Milker’s nodule - Case report

Cited by 18 publications

References 4 publications

Milker's nodules: classic histological findings

Milker's nodules: classic histological findings

Rare occupational infection: two cases of paravaccinia – viral disease of milkers at Bukovyna

Milker's nodule: an occupational infection and threat to the immunocompromised

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