Onychomycosis in patients with chronic leg ulcer and toenail                         abnormalities

Cabete, Joana; Galhardas, Célia; Apetato, Margarida; Lestre, Sara

doi:10.1590/abd1806-4841.20152940

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…19 However, our findings are difficult to compare with other reports. Some of the previous studies included only patients with chronic leg ulcer, 22 or were designed in the opposite way, to analyze the prevalence of chronic venous insufficiency (CVI) in patients with toenail onychomycosis. 4,21 Cabete et al included 81 patients with chronic leg ulcer (mean age of 76.0 years), which was of venous etiology in 63%.…”

Section: Discussionmentioning

confidence: 99%

“…Onychomycosis was proven in 27.2% of patients and tinea pedis was observed in 7.4% of patients. 22 Kulac et al studied 42 patients with onychomycosis (mean age of 51 years) and 39 patients with healthy toenails. Using Valsalva maneuver and Doppler ultrasound, they diagnosed CVI in 35.7% of patients with onychomycosis and in 15.4% in the control group; the difference was statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Onychomycosis was proven in 27.2% of patients and tinea pedis was observed in 7.4% of patients. 22 Kulac et al. studied 42 patients with onychomycosis (mean age of 51 years) and 39 patients with healthy toenails.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that onychomycosis is more common in patients with CVD. 4,[19][20][21][22] Only a few studies on this topic have been published, and they included a smaller number of patients. To the best of our knowledge, none of the studies have included all stages of CVD and the majority of these studies did not define the clinical characteristics and severity of toenail onychomycosis.…”

Section: Introductionmentioning

confidence: 99%

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Toenail alterations in chronic venous disease patients are not always of mycotic origin

et al. 2018

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Objective The prevalence of toenail alterations in chronic venous disease has only rarely been studied. We aimed to establish the frequency and clinical characteristics of toenail onychomycosis in chronic venous disease. Methods We included 80 adult patients, in all stages of chronic venous disease. Onychomycosis was confirmed by mycological examination. The clinical type of onychomycosis and the onychomycosis severity index were determined. Clinical characteristics of non-fungal nail changes were also analyzed. Results We included 58 women and 22 men, with a mean age of 67.0 years. Pathological toenail changes were observed in 83.8% of patients. Onychomycosis was confirmed in 33.8% of all patients and was more frequent in higher clinical stages of chronic venous disease (p = 0.009). Trichophyton rubrum was the leading causative pathogen. Disto-lateral onychomycosis was most commonly present. Average onychomycosis severity index was 23.1. Conclusion Onychomycosis accounted for 40% of all toenail alterations. Patients with chronic venous disease often have severe and difficult to treat toenail onychomycosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toenail alterations in chronic venous disease patients are not always of mycotic origin

et al. 2018

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“…It is common in daily practice to see patients with TON who have been treated with antifungal therapy without mycological confirmation. Prior confirmation of fungal infection is essential, thus avoiding risks of serious adverse effects of systemic medications, prolonged treatments, and unnecessary costs [8][9][10][11]. The aim of this study was to determine the prevalence of onychomycosis among patients with TON associated with subungual hyperkeratosis.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Onychomycosis among Patients with Transverse Overcurvature of the Nail: Results of a Cross-Sectional Study

Noriega

Chiacchio

Mello

et al. 2020

Skin Appendage Disord

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Introduction: Transverse overcurvature of the nail (TON) represents one of the main reasons for dermatological consultations due to nail conditions. Association between TON and subungual hyperkeratosis is common and simulates onychomycosis, constituting a difficult differential diagnosis by clinical features. Many cases are treated in daily practice with antifungal therapy even without mycological confirmation. The aim of this study was to determine the prevalence of onychomycosis among patients with TON associated with subungual hyperkeratosis. Methods: All subjects with clinical diagnosis of TON and subungual hyperkeratosis were subjected to a thorough clinical history, detailed clinical examination, digital photography, and collection of nail clipping and subungual debris for histopathological and microbiological examination (direct microscopy). Results: Sixtyfive samples were collected from 62 female (95.4%) and 3 male (4.6%) participants. Age range was between 34 and 83 years (mean age, 61.2 years). Twenty-eight samples were positive for onychomycosis, giving a 43.07% prevalence rate of onychomycosis among TON associated with hyperkerato-sis. Discussion/Conclusion: According to our data, the prevalence of onychomycosis in patients with TON associated with subungual hyperkeratosis was 43.07%, confirming the need to rule out fungal infection in TON associated with subungual hyperkeratosis prior to considering any unnecessary antifungal treatment.

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