Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples

Abstract

Chronic mucocutaneous candidiasis is a rare disorder characterized by persistent and recurrent infections by Candida due to changes in cellular immunity and may be associated with autoimmune endocrine disorders. It is refractory to the usual antifungal treatments, which merely control it with imidazole derivatives. This reports the case of a 50-year-old female patient who referred vaginal discharge associated with vulvar ulcerated lesions and whitish plaques on oral and genital mucous membranes of onset in adolescence besides cutaneous horns in nipples. The clinical picture, family history, culture and anatomopathological studies were consistent with chronic infection by candida. Treatment with systemic antifungals obtained partial response of lesions characterizing a clinical picture of Chronic Mucocutaneous Candidiasis.

Sensitivity to antifungals by Candida spp samples isolated from cases of chronic atrophic candidiasis (CAC)

“…The most common Newton classification of CAC is type II, which corresponds to an area of diffuse erythema on the palate (Newton, 1962;Chambo-Filho et al, 2014), consistent with the higher prevalence of type II lesions observed in the present study. This distribution most likely occurs because patients with CAC often wear complete dentures, which entails a larger surface area of contact between the prosthesis and palate.…”

“…Among the several clinical forms of candidiasis, CAC is considered one of the most ubiquitous of all opportunistic infections, frequently co-occurring with angular cheilitis, at the labial commissures, or in the "kissing lesion" of the dorsum of the tongue (Rao, 2012;Chambo-Filho et al, 2014;Brandolt et al, 2017;Hellstein & Marek, 2019). Studies suggest that women are more affected than men; however, it is known that women are more likely to seek medical attention and that incidence increases with advancing age, i.e., older adults have a higher prevalence of this condition, particularly due to denture use and difficulties in oral hygiene (Rao, 2012;Chambo-Filho et al, 2014).…”

“…Oral candidiasis is a common chronic condition that affects a large proportion of the population, especially denture wearers. Chronic atrophic candidiasis (CAC), also known as denture stomatitis, is the most common manifestation of Candida infection and affects more than 65% of individuals wearing maxillary partial dentures (Gonçalves et al, 2013;Chambo-Filho et al, 2014;Santos et al, 2016;Punnia-Moorthy, 2019). CAC is usually detected during intraoral examination and characterized as inflammation and erythema of the oral mucosal surfaces covered by the dental prosthesis (Armstrong et al, 2016).…”

Yeast and Filaments Have Specialized, Independent Activities in a Zebrafish Model of Candida albicans Infection

“…To cause invasive infections, some pathogenic fungi transition between yeast and filament forms, while others cause infections as single morphotypes (1)(2)(3)(4)(5)(6)(7). Candida albicans is unusual among fungal pathogens in that it grows in both yeast and filamentous forms during infection of humans, mice, zebrafish, and invertebrate hosts (8)(9)(10)(11)(12)(13)(14)(15). While both forms contribute to virulence, it is still unclear how this differentiation between shapes drives specific aspects of pathogenesis.…”

Candida ve Kandidoz: Epidemiyoloji, Tanı, Tedavi, Antifungal İlaç Direnci ve Konağın Genetik Yatkınlığında Güncel Durum

“…Chambô Filho ve ark. (17) meme başın-da deri boynuzu şeklinde ortaya çıkan bir kronik mukokütanöz kandidoz olgusunu rapor etmişler-dir. Vaskülitli bir hastada ise Candida albicans'a bağlı penil miçetoma, ilk kez bildirilmiştir (18) .…”