Correlation between psoriasis' severity and waist-to-height ratio

Duarte, Gleison Vieira; Silva, Larissa Porto da

doi:10.1590/abd1806-4841.20142854

Cited by 15 publications

(12 citation statements)

References 8 publications

(9 reference statements)

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“…[54] At the same time, obesity is a common comorbidity of psoriasis and psoriatic disease severity has been positively correlated with body mass index and waist to height ratio. [55, 56] Adipocytokines have also been posited to contribute to the systemic inflammation in psoriasis. [57] Thus, an imbalance in the Firmicutes/Bacteroidetes ratio in the psoriatic gut microbiome may reflect the relationship between psoriasis and its cardiovascular and metabolic comorbidities.…”

Section: Discussionmentioning

confidence: 99%

The Role of the Skin and Gut Microbiome in Psoriatic Disease

et al. 2017

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Purpose To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls. Findings Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of Streptococcus and a decreased level of Propionibacterium in psoriasis patients compared to controls. In the gut microbiome, the ratio of Firmicutes and Bacteroidetes was perturbed in psoriatic individuals compared to healthy controls. Actinobacteria was also relatively underrepresented in psoriasis patients relative to healthy individuals. Summary Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

The Role of the Skin and Gut Microbiome in Psoriatic Disease

et al. 2017

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“…[ 12 ] established that for each unit increment increase in body mass index (BMI), there was a 9% higher risk for psoriasis onset and 7% higher risk for PASI. Recent studies show that WHR has a stronger correlation with cardiovascular diseases [ 13 ]. Our study also showed associations between psoriasis and obesity ( p = 0.43) with high WHR compared with the general population.…”

Section: Discussionmentioning

confidence: 99%

Presence of selected metabolic syndrome components in patients with psoriasis vulgaris

Uczniak¹,

Gerlicz²,

Kozłowska³

et al. 2016

pdia

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IntroductionRecent studies have suggested a strong association between psoriasis and obesity, dyslipidemia, hypertension, resistance to insulin and metabolic syndrome.AimTo assess the prevalence of selected metabolic syndrome components in patients with psoriasis and the effect of the abnormalities on the disease activity.Material and methodsTwo hundred and forty-six patients diagnosed with psoriasis and 75 healthy individuals as controls were included in the study. Psoriasis activity was evaluated by the Psoriasis Area and Severity Index (PASI).ResultsThere was a statistically significant difference in triglyceride concentration between psoriasis patients and controls (p = 0.00001), which was not found for high-density lipoprotein (HDL) concentration. Mean values of serum glucose level in patients with psoriasis were significantly higher than in controls (p = 0.046). Further statistical analysis of the obtained results showed significantly higher systolic blood pressure in the psoriasis patients than in the controls (p = 0.0001), but there was no statistically significant difference in diastolic blood pressure between the investigated groups (p > 0.05).ConclusionsHigher prevalence of metabolic syndrome components was observed in patients with psoriasis than in the general population.

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“…Furthermore, a large body of evidence revealed that psoriasis is related to obesity and especially central obesity . Accordingly, psoriasis patients are more likely to suffer from insulin resistance compared to normal controls and various studies have found that the prevalence rate (PR) of DM is higher in patients with psoriasis …”

Section: Introductionmentioning

confidence: 99%

“…12,21 Furthermore, a large body of evidence revealed that psoriasis is related to obesity 7,[22][23][24][25] and especially central obesity. 26,27 Accordingly, psoriasis patients are more likely to suffer from insulin resistance compared to normal controls 28 and various studies have found that the prevalence rate (PR) of DM is higher in patients with psoriasis. 6,7,11,29,30 Metabolic syndrome is a highly prevalent, multifaceted condition characterized by a constellation of abnormalities that include abdominal obesity, hypertension, dyslipidemia and elevated blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Psoriasis, cardiovascular risk factors and metabolic disorders: sex‐specific findings of a population‐based study

Sondermann

Deudjui

Körber³

et al. 2019

Acad Dermatol Venereol

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Background Scientific evidence suggests an association between psoriasis and cardiovascular and metabolic diseases. However, there are hardly any sex‐specific results from population‐based studies reporting the prevalence of cardiovascular risk factors in patients with psoriasis and point estimates of the association between psoriasis and cardiovascular and metabolic disorders. Objective Aims are to evaluate the sex‐specific prevalence of psoriasis and cardiovascular risk factors, and to estimate sex‐specific associations between psoriasis and diabetes type 2 (DM) and metabolic syndrome (MetS). Methods We used data of 3723 participants (45–75 years, 54.1% women) without coronary heart disease and missing data (psoriasis, DM, MetS) from the Heinz Nixdorf Recall study. Standardized information on health outcomes and risk factors was assessed. We performed descriptive statistics and multiple regression analyses to calculate prevalence rate ratios (PR) and 95% confidence intervals (95% CI). Results The prevalence of psoriasis was 3.8% (n = 143), with no differences between sex. We observed more often metabolic and cardiovascular risk factors in women with psoriasis compared to women without psoriasis. Interestingly, in men, this pattern was partly reversed. Multiple regression analyses revealed distinctly elevated PRs for DM for both women and men with psoriasis (fully adjusted PR: 2.43; 95% CI: 1.17–5.07, resp. 2.09; 1.16–3.76). Regarding the MetS, the results were inconsistent, showing a positive association between psoriasis and MetS in women (1.84; 1.14–2.98), but a negative association in men, even though with a wide 95% CI (0.69; 0.42–1.12). Conclusion The results of our cross‐sectional, population‐based analysis show a distinct association between psoriasis and DM, whereas for the MetS the results contrasted between men and women, translating in women with MetS showing a higher and in men a lower chance to be psoriatic. Our results emphasize the urgent need for sex‐specific research, studying the effects of psoriasis on metabolic disorders as well as effective sex tailored prevention measures.

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Correlation between psoriasis' severity and waist-to-height ratio

Cited by 15 publications

References 8 publications

The Role of the Skin and Gut Microbiome in Psoriatic Disease

The Role of the Skin and Gut Microbiome in Psoriatic Disease

Presence of selected metabolic syndrome components in patients with psoriasis vulgaris

Psoriasis, cardiovascular risk factors and metabolic disorders: sex‐specific findings of a population‐based study

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