Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients

Teixeira, Vera; Cabral, Rita; Brites, Maria Manuel; Vieira, Ricardo; Figueiredo, Américo

doi:10.1590/abd1806-4841.20142516

Cited by 74 publications

(106 citation statements)

References 24 publications

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“…The control group consisted of an equal number of healthy individuals (33 females and 24 males), aged 38-81 (mean 60.66± 11.26). No statistically significant (NS) difference between patients and controls was documented in terms of age (t=0.45, p>0.05, NS) and sex (x 2 =0.14, p>0.05, NS).…”

Section: Resultsmentioning

confidence: 80%

Quality of life, depression, anxiety and loneliness in patients with bullous pemphigoid. A case control study

Kouris

Platsidaki

Armyra

et al. 2016

An. Bras. Dermatol.

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BackgroundBullous pemphigoid (BP) is a chronic, autoimmune blistering skin disease that affects patients' daily life and psychosocial well-being.ObjectiveThe aim of the study was to evaluate the quality of life, anxiety, depression and loneliness in BP patients.MethodsFifty-seven BP patients and fifty-seven healthy controls were recruited for the study. The quality of life of each patient was assessed using the Dermatology Life Quality Index (DLQI) scale. Moreover, they were evaluated for anxiety and depression according to the Hospital Anxiety Depression Scale (HADS-scale), while loneliness was measured through the Loneliness Scale-Version 3 (UCLA) scale.ResultsThe mean DLQI score was 9.45±3.34. Statistically significant differences on the HADS total scale and in HADS-depression subscale (p=0.015 and p=0.002, respectively) were documented. No statistically significant difference was found between the two groups on the HADS-anxiety subscale. Furthermore, significantly higher scores were recorded on the UCLA Scale compared with healthy volunteers (p=0.003).ConclusionBP had a significant impact on quality of life and the psychological status of patients, probably due to the appearance of unattractive lesions on the skin, functional problems and disease chronicity.

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Section: Resultsmentioning

confidence: 80%

Quality of life, depression, anxiety and loneliness in patients with bullous pemphigoid. A case control study

Kouris

Platsidaki

Armyra

et al. 2016

An. Bras. Dermatol.

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“…It has been reported that BP patients are more likely than the general population to have schizophrenia before their BP diagnosis7, and unipolar and bipolar disorders are also associated with BP11. On the contrary, another study found no connection between BP and depression12 and none of these studies have reported whether the risk for psychiatric disorders is elevated after the diagnosis of BP.…”

mentioning

confidence: 98%

Psychiatric and neurological disorders are associated with bullous pemphigoid – a nationwide Finnish Care Register study

Försti

Jokelainen

Ansakorpi

et al. 2016

Sci Rep

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Bullous pemphigoid (BP) is an autoimmune blistering skin disease with increasing incidence. BP is associated with neurological disorders, but it has not been established, what subtypes of dementia and stroke are associated with BP, and what is the temporal relation between these diseases. Also, the association between BP and psychiatric disorders is controversial. We conducted a retrospective nationwide study, using the Finnish Care Register for Health Care diagnoses between 1987 and 2013. The study population of 4524 BP patients were compared with 66138 patients with basocellular carcinoma (BCC), neurological and psychiatric comorbid disorders were evaluated for both groups, and associations were estimated by Cox regression and logistic regression analyses. The strongest risk of developing BP was found after diagnosis of multiple sclerosis (MS) (OR=5.9, 95% CI 3.9–8.5). Among psychiatric diseases, the corresponding risk was strongest in schizophrenia (OR=2.7, 95% CI 2.0–3.5), and as a novel finding, also personality disorders (OR=2.2, 95% CI 1.3–3.3) preceded BP. In conclusion, many psychiatric disorders, especially schizophrenia, carry heightened risk for BP. Furthermore, several neurological diseases which cause central nervous system inflammation or degeneration were related to BP, and the association was strongest between MS and BP.

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“…6 A incidência de PB está estimada em dois a 14 novos casos por milhão, sem predominância por género. 7 Manifesta-se através de uma erupção cutânea polimórfica, tipicamente constituída por bolhas subepidérmicas tensas, que podem ter distribuição localizada ou generalizada. O envolvimento das mucosas é pouco comum, estando descrito em cerca de 10 a 25% dos casos.…”

Section: Discussionunclassified

“…: aspirina, captopril, furosemida, penicilina) e a presença de comorbilidades como síndromes linfoproliferativas, diabetes mellitus e doenças neurodegenerativas. 5,7 A relação causal entre as doenças do foro neurológico e a ocorrência de penfigoide bolhoso tem sido muito investigada nos últimos anos. [1][2][3][4][5]7 Embora a sua patogénese ainda não esteja totalmente esclarecida, acredita-se que os processos neurodegenerativos possam predispor o desenvolvimento de PB, através da ativação de mecanismos autoimunes, que produzem autoanticorpos contra antigénios presentes nas células cutâneas e do sistema nervoso central.…”

Section: Discussionunclassified

“…5,7 A relação causal entre as doenças do foro neurológico e a ocorrência de penfigoide bolhoso tem sido muito investigada nos últimos anos. [1][2][3][4][5]7 Embora a sua patogénese ainda não esteja totalmente esclarecida, acredita-se que os processos neurodegenerativos possam predispor o desenvolvimento de PB, através da ativação de mecanismos autoimunes, que produzem autoanticorpos contra antigénios presentes nas células cutâneas e do sistema nervoso central. [1][2][3][4] Estas observações são reforçadas pelo facto de ambos os tecidos (cutâneo e sistema nervoso) serem originados a partir da crista neural.…”

Section: Discussionunclassified

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Síndrome Demencial como Fator de Risco para Penfigoide Bolhoso

Graça¹,

Moitinho²,

Macias³

et al. 2017

Gaz Med

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RESUMOO penfigoide bolhoso é uma patologia cutânea autoimune adquirida, mais frequente nos idosos. Estudos recentes demonstraram a associação causal entre a ocorrência de penfigoide bolhoso em doentes com síndromes demenciais. Apresentamos o caso de uma doente do sexo feminino, 80 anos, com antecedentes de doença de Parkinson, internada por dermatose bolhosa extensa, constituída por placas urticariformes e bolhas tensas com halo eritematoso, sem envolvimento das mucosas. Após confirmação por biópsia cutânea, imunofluorescência direta positiva e exclusão de outras causas, foi feito o diagnóstico de penfigoide bolhoso. Foi instituída terapêutica com prednisolona, azatriopina e doxiciclina, verificando-se evolução clínica favorável. Consideramos o presente caso clínico pertinente, pois realça a importância do diagnóstico precoce de penfigoide bolhoso. O atraso no início do tratamento pode levar a complicações graves, com elevada morbi-mortalidade. PALAVRAS-CHAVE

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Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients

Cited by 74 publications

References 24 publications

Quality of life, depression, anxiety and loneliness in patients with bullous pemphigoid. A case control study

Quality of life, depression, anxiety and loneliness in patients with bullous pemphigoid. A case control study

Psychiatric and neurological disorders are associated with bullous pemphigoid – a nationwide Finnish Care Register study

Síndrome Demencial como Fator de Risco para Penfigoide Bolhoso

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