“…In addition, a high level of BetaPV in proliferative skin lesions with a documented risk of progression to skin cancer has been recently reported in an unclassified primary T cell immunodeficiency [87], as well as in patients with T cell defects associated with mutations in the RHOH and MST1 genes [88,89]. Patients with acquired immunodeficiency, such as can occur following HIV infection, can also develop EV-like proliferative lesions [90,91]. Whether EV should be considered an immunodeficiency in its own right deserves further study, given that EVER A B Understanding Disease Figure 6.…”