Epidermodysplasia verruciformis in a young man with HIV since birth - case report

Abstract

Epidermodysplasia Verruciformis is a genodermatosis characterized by susceptibility to infection by specific HPV types (HPV 3/10 and beta-HPVs). It is considered to be the first model in human carcinogenesis induced by HPV. In this report we present a rare case of Epidermodysplasia Verruciformis associated with vertical transmission of HIV. Although most patients with HIV present infections by HPV virus, the frequency of Epidermodysplasia Verruciformis is no greater in patients with HIV because in EV there is a deficiency of specific cellular immunity to infection by some types of HPV, called HPV-related Epidermodysplasia Verruciformis.

Human Beta‐papillomavirus infection and keratinocyte carcinomas

“…In addition, a high level of BetaPV in proliferative skin lesions with a documented risk of progression to skin cancer has been recently reported in an unclassified primary T cell immunodeficiency [87], as well as in patients with T cell defects associated with mutations in the RHOH and MST1 genes [88,89]. Patients with acquired immunodeficiency, such as can occur following HIV infection, can also develop EV-like proliferative lesions [90,91]. Whether EV should be considered an immunodeficiency in its own right deserves further study, given that EVER A B Understanding Disease Figure 6.…”