Congenital agminated melanocytic nevus - case report

Rocha, Camila Roos Mariano da; Grazziotin, Thaís Corsetti; Rey, Maria Carolina Widholzer; Luzzatto, Laura; Bonamigo, Renan Rangel

doi:10.1590/abd1806-4841.20132137

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…[26][27][28][29] As dermoscopy improves the detection of melanomas, 30 its use was suggested in the monitoring of congenital melanocytic naevi (CMN), especially the smaller CMN. [31][32][33] Sequential digital dermoscopy imaging can also reduce the unnecessary excision of suspicious pigmented skin lesions. 34 This has been emphasised in children with epidermolysis bullosa who are at risk of developing skin cancers, and in whom overtreatment of the fragile skin should be avoided.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopy for common skin problems in Chinese children using a novel Hong Kong-made dermoscope

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Dermoscopy for common skin problems in Chinese children using a novel Hong Kong-made dermoscope

et al. 2014

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“…Agminated melanocytic nevi are characterized by the presence of multiple cutaneous clustered nevi 1–3 . These lesions can arise on an underlying nevus spilus, normal‐appearing background skin, after radiation or chemotherapy, and in immunosuppressed states 4–10 .…”

Section: Introductionmentioning

confidence: 99%

Agminated presentation of fusion‐driven melanocytic neoplasms

et al. 2023

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Background: The conventionally understood pathogenesis of agminated Spitz nevi includes a mosaic HRAS mutation followed by copy number gains in 11p. However, we have recently observed agminated presentations of fusion-driven melanocytic neoplasms.Methods: We retrieved cases from our database of benign fusion-induced melanocytic neoplasms with an agminated presentation. Both the primary lesion and the secondary lesion were sequenced. TERT-promoter mutational testing and the melanoma fluorescence in situ hybridization assay were also performed.Results: Three cases were included. Two had a PRKCA fusion (partners ATP2B4 and MPZL1) and one had a ZCCHC8::ROS1 fusion. None of the cases met morphologic or molecular criteria for malignancy. There was no evidence of tumor progression in secondary lesions. The same fusion was identified in the primary and secondary lesions. None of the patients developed evidence of nodal or systemic metastasis. Conclusions:We present accumulating evidence that fusion-driven melanocytic neoplasms can present with an agminated presentation. The differential diagnosis of an agminated presentation versus a locally recurrent or potentially locally metastatic tumor is critical, and accurate diagnosis has significant prognostic and therapeutic consequences for the patient. As with HRAS mutations, fusion-driven melanocytic tumors may have an agminated presentation.

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Agminated melanocytic nevus is a rare subtype of melanocytic nevi in which congenital or acquired melanocytic lesions are usually clustered on normal background skin with a linear, unilateral or segmental distribution resembling the lines of Blaschko. [1][2][3] The term agminated is derived from the Latin word "agmen," which is referring to aggregation or clustering of the lesions usually in a segmental pattern. 1 Different melanocytic tumors can occasionally

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“…appear as agminated lesions. [1][2][3] In these cases, the agminated macules dermoscopically lacked background pigmentation, unlike speckled lentiginous nevus. This appearance of agminated nevi was linked to the clonal proliferation of cells originating from a somatic mutation at an early stage of embryogenesis in congenital variant; however, in acquired cases the pathogenesis is not clear yet.…”

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confidence: 99%