Psoriasis: correlation between severity index (PASI) and systemic treatment

Abstract

BACKGROUND Psoriasis is a chronic inflammatory disease of the skin that affects patients of all ages andboth genders. The impact of the disease on quality of life is greater among patients with moderate to severe psoriasis. OBJECTIVE to establish a correlation between the psoriasis area and severity index (PASI) and theDermatology Life Quality Index (DLQI) based on a quality of life questionnaire adapted to the Brazilian contextfor patients with plaque psoriasis before and after systemic treatment. METHODSThis was a cross-sectional, descriptive study of psoriasis patients who did not undergo treatment or who manifested clinical activity of the disease. Patients were evaluated according to the PASI and the quality of life questionnaire adapted to theBrazilian context before and 60 days after systemic treatment. RESULTS Thirty-five patients participated in thestudy. Twenty-six were men, with a mean age of 46 years. There was no correlation between the PASI and thequality of life questionnaire adapted to the Brazilian context, but there was a correlation between the PASI andsome items of the quality of life questionnaire adapted to the Brazilian context, such as jobs involving public contact. CONCLUSIONThe non-correlation between the PASI and the quality of life questionnaire adapted to the Brazilian context in this work may be associated with a history of chronic disease, which implies greater acceptance of the illness, or may be related to the low income and social status of the patients studied. The correlationobserved among patients with careers involving public contact suggests that some professions are more impacted by the disease. It may be necessary to adapt the quality of life questionnaire to patients with a low income andcultural and social limitations. The small sample size (n=35 patients) and the short follow-up period of 60 dayswere some of the limitations of this work.

Psoriasis: Correlation between severity index (PASI) and quality of life index (DLQI) based on the type of treatment

“…Psoriasis is a relatively common, chronic condition affecting between 1% and 3% of the general population (Grob and Folchetti, 1999;Koo, 1996;da Silva et al, 2013). Classic psoriasis vulgaris usually appears in specific areas including the elbows, knees and scalp.…”

“…DLQI has-been found highly sensitive to improvements in psoriasis symptoms and shows a positive correlation with the psoriasis area severity index (PASI) (Basra et al, 2008;Revicki et al, 2008). There are relatively few studies in the literature examining the correlation between quality of life and symptom severity in patients with psoriasis (da Silva et al, 2013).…”

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey

“…Methotrexate inhibits the dihydrofolate reductase enzyme, which plays a key role in the folate cycle. 6 Only four studies have stated that polymorphisms of the MTHFR gene could be associated with methotrexate efficacy in psoriasis patients. 21,24 Chandran et al and Campalani et al demonstrated that MTHFR 677TT polymorphism may be related to methotrexate-induced liver toxicity in Canadian and UK populations, respectively.…”

“…4,5 Furthermore, some studies reported increased levels of plasma homocysteine and a decreased folic acid concentration in psoriasis patients. 4,6 Today, hyperhomocysteinemia is a recognised risk factor for cardiovascular diseases and psoriasis. 4,7 …”

Fatores desencadeantes em dermatoses crônicas de crianças com perfis internalizante e externalizante segundo relato materno

“…Essas doenças podem estar presentes desde a infância e afetam a qualidade de vida do paciente ao interferir negativamente nos âmbitos físico, social e emocional de sua vida (Alvarenga & Caldeira, 2009;Barbarot et al, 2007;Gon, Gon, & Zazula, 2013;Manzoni et al, 2012;Silva, Fortes, Miot, & Marques, 2013;Tejada, Mendoza-Sassi, Almeida, Figueiredo, & Tejada, 2011;Torres, Silva, Magalhães, Morcillo, & Velho, 2011;Weber, Lorenzini, Reinehr, & Lovato, 2012). Rotina de tratamento, cuidados constantes com a pele, restrição na participação em atividades esportivas e de lazer e exposição a situações de estigmatização pela visibilidade das lesões podem dificultar a adaptação à doença e tornar-se um evento estressor recorrente (Castro & Piccinini, 2002;Gon, Rocha, & Gon, 2005;Pires & Cestari, 2005).…”