Prognosis of patients with systemic lupus erythematosus and discoid lesions

Abstract

BACKGROUND It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODSWe carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSIONPatients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP.

Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain

“…Plasma levels of cell-free heme are elevated in several hemolytic and chronic inflammatory diseases, such as sickle cell disease [ 35 , 41 , 42 ], lupus arthritis [ 64 ], malaria [ 65 ], and following treatment with widely used platinum-based anticancer drugs [ 66 ]. However, the role of heme in HIV associated co-morbidities has not been yet elucidated.…”

Risk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: A retrospective cohort study

“…Regarding the skin manifestations at TD, we found that those with discoid rashes were less likely to have subsequent LN overall. Several studies have reported that patients with SLE with mucocutaneous lesions tend to have less vital organ involvement [54,55]. A British study that included 241 patients with jSLE found that those without skin manifestations tended to have more haematological and renal involvement [56].…”

Discoid lupus erythematosus: First clue to autoimmune haemolytic anaemia in a child

“…The median age at diagnosis of DLE is 30 years 1 . SLE appears in 17-30% presenting as only discoid lesions and discoid lesions appear in 8-28% of SLE 3,4,5 .…”

“…It has been described as part of systemic lupus erythematosus (SLE) or in isolation in adults 1 . We report a case of severe haemolytic anaemia with discoid lesions that gave a clue to diagnosis and management.…”